Abstract:
BACKGROUND:QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes. METHODS:One case is described in which a patient with schizophrenia, who was being treated for dyslipidemia, developed a prolonged QTc interval while taking quetiapine and lovastatin. RESULTS:QTc returned to baseline when the lovastatin dose was reduced. CONCLUSIONS:QTc prolongation associated with antipsychotic medication occurs in a dose-dependent manner. We therefore hypothesize that the addition of lovastatin caused an increase in plasma quetiapine levels through competitive inhibition of the cytochrome P(450) (CYP) isoenzyme 3A4. Our case highlights the potential for a drug interaction between quetiapine and lovastatin leading to QTc prolongation during the management of dysipidemia in patients with schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Furst BA,Champion KM,Pierre JM,Wirshing DA,Wirshing WCdoi
10.1016/s0006-3223(01)01333-6subject
Has Abstractpub_date
2002-02-01 00:00:00pages
264-5issue
3eissn
0006-3223issn
1873-2402pii
S0006322301013336journal_volume
51pub_type
杂志文章abstract:BACKGROUND:Posttraumatic stress disorder (PTSD) co-occurs with substance use disorders at high rates, but the neurobiological basis of this relationship is largely unknown. PTSD and drug addiction each involve dysregulation of brain reward circuitry; therefore, the identification of pathology of the mesolimbic dopamine...
journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2015-12-15 00:00:00
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1996-08-15 00:00:00
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journal_title:Biological psychiatry
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pub_type: 临床试验,杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2004-04-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1996-07-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2010-09-15 00:00:00
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更新日期:2017-11-15 00:00:00
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pub_type: 杂志文章
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更新日期:1991-03-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
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更新日期:1993-10-15 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-05-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2013.10.027
更新日期:2014-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2018.02.1172
更新日期:2018-09-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01323-3
更新日期:2002-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(99)00272-3
更新日期:2000-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/s0006-3223(96)00214-4
更新日期:1997-06-15 00:00:00