Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin.

Abstract:

BACKGROUND:QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes. METHODS:One case is described in which a patient with schizophrenia, who was being treated for dyslipidemia, developed a prolonged QTc interval while taking quetiapine and lovastatin. RESULTS:QTc returned to baseline when the lovastatin dose was reduced. CONCLUSIONS:QTc prolongation associated with antipsychotic medication occurs in a dose-dependent manner. We therefore hypothesize that the addition of lovastatin caused an increase in plasma quetiapine levels through competitive inhibition of the cytochrome P(450) (CYP) isoenzyme 3A4. Our case highlights the potential for a drug interaction between quetiapine and lovastatin leading to QTc prolongation during the management of dysipidemia in patients with schizophrenia.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Furst BA,Champion KM,Pierre JM,Wirshing DA,Wirshing WC

doi

10.1016/s0006-3223(01)01333-6

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

264-5

issue

3

eissn

0006-3223

issn

1873-2402

pii

S0006322301013336

journal_volume

51

pub_type

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