当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > A comparison of symptom provocation procedures in psychiatry and other areas of medicine: implications for their ethical use in research.

A comparison of symptom provocation procedures in psychiatry and other areas of medicine: implications for their ethical use in research.

Abstract：

BACKGROUND:Symptom provocation is used to study a wide variety of medical disorders. In contrast to other areas of medicine, the application of these procedures to the study of mental disease has generated significant scientific, political, and public debate. Purported differences include an overabundance of these procedures in psychiatry and a lack of diagnostic and therapeutic utility. Accurate appraisal of these research designs is needed to address scientific merit and ethical concerns. This article provides a general review of challenge studies in several areas of medical research, compares purposes and methods to those used in psychiatry, and ascertains whether fundamental differences exist. METHODS:In total, 655 challenge studies were identified using MEDLINE and PsychInfo Boolean key word searches. Information was collected from each study including the year of publication, whether subjects were healthy or patient volunteers, the disease being studied, and the study purpose (e.g., to study pathophysiology, test treatment efficacy, or diagnosis of a disorder). RESULTS:Differences in study design, purpose, and frequency of studies across time were similar for medical and psychiatric diseases. CONCLUSIONS:Given extensive similarity in purpose and procedures, why are psychiatric challenge studies being subjected to public criticism and special review and approval procedures? Several relevant issues are addressed including risk, scientific merit, and clinical application.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Avila MT,Conley RR,Carpenter WT

doi

10.1016/s0006-3223(01)01221-5

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

479-86

issue

7

eissn

0006-3223

issn

1873-2402

pii

S0006322301012215

journal_volume

50

pub_type

杂志文章,评审

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients.

    abstract：BACKGROUND:Abnormal sensory gating in schizophrenia has frequently been reported; however, only limited data on unmedicated patients and patients at risk to develop a psychosis have, as yet, been available. METHODS:P50 and N100 suppression were assessed with an auditory double-click paradigm in five groups: 18 at-risk...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.02.006

    authors： Brockhaus-Dumke A,Schultze-Lutter F,Mueller R,Tendolkar I,Bechdolf A,Pukrop R,Klosterkoetter J,Ruhrmann S

    更新日期：2008-09-01 00:00:00

  • Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone.

    abstract：BACKGROUND:Corticotropin-releasing hormone (CRH) hyperactivity in transgenic mice overexpressing CRH in the brain (CRH-OE(2122)) appears to be associated with chronic stress-like alterations, including increased CRH content in the hypothalamus, changes in hypothalamus-pituitary-adrenal axis regulation, and increased he...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01323-3

    authors： Dirks A,Groenink L,Schipholt MI,van der Gugten J,Hijzen TH,Geyer MA,Olivier B

    更新日期：2002-04-01 00:00:00

  • Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging.

    abstract：BACKGROUND:Psychological stress and trauma are risk factors for several medical and psychiatric illnesses. Recent studies have implicated advanced cellular aging as a potential mechanism of this association. Telomeres, DNA repeats that cap the ends of chromosomes and promote stability, shorten progressively with each c...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.08.014

    authors： Tyrka AR,Price LH,Kao HT,Porton B,Marsella SA,Carpenter LL

    更新日期：2010-03-15 00:00:00

  • Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain.

    abstract：BACKGROUND:The antidepressant-like effects of brain-derived neurotrophic factor (BDNF) infusions in brain, and the upregulation of BDNF mRNA and its receptor in rats exposed to electroconvulsive seizure (ECS) and antidepressants, suggested a role for increased BDNF protein. METHODS:We measured BDNF protein levels with...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00073-8

    authors： Altar CA,Whitehead RE,Chen R,Wörtwein G,Madsen TM

    更新日期：2003-10-01 00:00:00

  • A polymorphism in the dopamine beta-hydroxylase gene is associated with "paranoid ideation" in patients with major depression.

    abstract：BACKGROUND:Increased dopaminergic activity may play a primary role in psychotic depression. Dopamine beta-hydroxylase (DbetaH) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low DbetaH activity is a possible risk factor for developing psychotic depression. An exon 2 poly...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01367-1

    authors： Wood JG,Joyce PR,Miller AL,Mulder RT,Kennedy MA

    更新日期：2002-03-01 00:00:00

  • Neuroimaging-based Individualized Prediction of Cognition and Behavior for Mental Disorders and Health: Methods and Promises.

    abstract：:The neuroimaging community has witnessed a paradigm shift in biomarker discovery from using traditional univariate brain mapping approaches to multivariate predictive models, allowing the field to move toward a translational neuroscience era. Regression-based multivariate models (hereafter "predictive modeling") provi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2020.02.016

    authors： Sui J,Jiang R,Bustillo J,Calhoun V

    更新日期：2020-12-01 00:00:00

  • Monoamine oxidase A and B activities in heavy smokers.

    abstract：:There is a strong association between depression and smoking. Because monoamine oxidase (MAO) inhibition leads to antidepressant effect and in vitro studies have shown that cigarette smoke inhibits MAO activity, it is conceivable that smoking may have an antidepressant effect, if smokers have reduced MAO activity. The...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0006-3223(95)00084-4

    authors： Berlin I,Said S,Spreux-Varoquaux O,Olivares R,Launay JM,Puech AJ

    更新日期：1995-12-01 00:00:00

  • The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder.

    abstract：BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.02.019

    authors： Lake EMR,Finn ES,Noble SM,Vanderwal T,Shen X,Rosenberg MD,Spann MN,Chun MM,Scheinost D,Constable RT

    更新日期：2019-08-15 00:00:00

  • Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.

    abstract：BACKGROUND:Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety. Within the 5-HT1A receptor gene, a powerful dual repressor element (DRE) is regulated ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.02.033

    authors： Hadjighassem MR,Austin MC,Szewczyk B,Daigle M,Stockmeier CA,Albert PR

    更新日期：2009-08-01 00:00:00

  • Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.

    abstract：BACKGROUND:Adenosine A2A receptors (A2AR) modulate dopamine and glutamate signaling and thereby may influence some of the psychomotor and cognitive processes associated with schizophrenia. Because astroglial A2AR regulate the availability of glutamate, we hypothesized that they might play an unprecedented role in some ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.02.026

    authors： Matos M,Shen HY,Augusto E,Wang Y,Wei CJ,Wang YT,Agostinho P,Boison D,Cunha RA,Chen JF

    更新日期：2015-12-01 00:00:00

  • Altered protein kinase a in brain of learned helpless rats: effects of acute and repeated stress.

    abstract：BACKGROUND:Stress-induced learned helplessness (LH) in animals serves as a model of behavioral depression and some aspects of posttraumatic stress disorder. We examined whether LH behavior is associated with alterations in protein kinase A (PKA), a critical phosphorylating enzyme, how long these alterations persist aft...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.03.018

    authors： Dwivedi Y,Mondal AC,Shukla PK,Rizavi HS,Lyons J

    更新日期：2004-07-01 00:00:00

  • A randomized double-blind fluvoxamine/placebo crossover trial in pathologic gambling.

    abstract：BACKGROUND:The study assessed the efficacy and tolerability of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in the treatment of pathologic gambling (PG). METHODS:A 16-week randomized double-blind crossover design insured that each subject received 8 weeks of fluvoxamine and 8 weeks of a placebo. Fifte...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(00)00241-9

    authors： Hollander E,DeCaria CM,Finkell JN,Begaz T,Wong CM,Cartwright C

    更新日期：2000-05-01 00:00:00

  • Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease.

    abstract：:Psychiatric and neurologic disorders ranging from mental retardation to addiction are accompanied by structural and functional alterations of synaptic connections in the brain. Such alterations include abnormal density and morphology of dendritic spines, synapse loss, and aberrant synaptic signaling and plasticity. Re...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2003.10.006

    authors： Blanpied TA,Ehlers MD

    更新日期：2004-06-15 00:00:00

  • Pretreatment brain states identify likely nonresponse to standard treatments for depression.

    abstract：BACKGROUND:Treatment approaches for major depressive disorder (MDD) result in approximately one third of patients achieving remission after a first treatment. Added treatment generally improves remission rates, but approximately one third of all patients fail to respond after several treatments (sequential monotherapie...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2013.12.005

    authors： McGrath CL,Kelley ME,Dunlop BW,Holtzheimer PE 3rd,Craighead WE,Mayberg HS

    更新日期：2014-10-01 00:00:00

  • Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons.

    abstract：BACKGROUND:Recent studies have raised concerns about subtle long-lasting neurobiological changes that might be triggered by exposure to Cannabis derivatives, especially in a critical phase of brain maturation, such as puberty. The mesolimbic dopamine (DA) system, involved in the processing of drug-induced reward, is a ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.05.006

    authors： Pistis M,Perra S,Pillolla G,Melis M,Muntoni AL,Gessa GL

    更新日期：2004-07-15 00:00:00

  • Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development.

    abstract：BACKGROUND:Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to neurobehavioral disorders. Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an id...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.01.017

    authors： Bruining H,Matsui A,Oguro-Ando A,Kahn RS,Van't Spijker HM,Akkermans G,Stiedl O,van Engeland H,Koopmans B,van Lith HA,Oppelaar H,Tieland L,Nonkes LJ,Yagi T,Kaneko R,Burbach JP,Yamamoto N,Kas MJ

    更新日期：2015-10-01 00:00:00

  • Lack of effects on core obsessive-compulsive symptoms of tryptophan depletion during symptom provocation in remitted obsessive-compulsive disorder patients.

    abstract：BACKGROUND:Pharmacological evidence support that enhancement of serotonin (5-HT) neurotransmission is critical for treatment efficacy in obsessive-compulsive disorder (OCD). Surprisingly, acute tryptophan depletion (ATD), a procedure known to reduce 5-HT neurotransmission, carried out in remitted OCD patients on select...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2005.08.023

    authors： Berney A,Sookman D,Leyton M,Young SN,Benkelfat C

    更新日期：2006-05-01 00:00:00

  • Ambulatory polysomnography of never-depressed borderline subjects: a high-risk approach to rapid eye movement latency.

    abstract：:The sleep parameters of never-depressed borderline subjects and age- and sex-matched normal controls were compared by continuous 48-hr ambulatory electroencephalographic (EEG) monitoring. Borderline subjects had a significantly shorter rapid eye movement latency, normal architecture of rapid eye movements sleep, and h...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0006-3223(93)90321-4

    authors： Battaglia M,Ferini-Strambi L,Smirne S,Bernardeschi L,Bellodi L

    更新日期：1993-03-01 00:00:00

  • Three and six-month outcome following courses of either ECT or rTMS in a population of severely depressed individuals--preliminary report.

    abstract：BACKGROUND:Recent studies have strengthened the claim that repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depression. The longitudinal outcome of TMS-treated patients, however, has not been described. We report on the 3- and 6-month outcomes of a group of patients treated with e...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(01)01274-4

    authors： Dannon PN,Dolberg OT,Schreiber S,Grunhaus L

    更新日期：2002-04-15 00:00:00

  • Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity.

    abstract：BACKGROUND:As many as 30% of individuals diagnosed with depression are nonresponsive to traditional antidepressant medication. Augmentation and combination strategies have emerged in an attempt to address this issue. Atypical antipsychotics (e.g., olanzapine), when added to a selective serotonin reuptake inhibitor (e.g...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.02.012

    authors： Seager MA,Huff KD,Barth VN,Phebus LA,Rasmussen K

    更新日期：2004-06-01 00:00:00

  • Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET.

    abstract：BACKGROUND:The aim of the present study was to investigate dopamine synthesis in the brain of drug-free schizophrenic patients, not only in the striatum but also in extrastriatal areas like the prefrontal cortex, brain areas that for a long time has been in focus of interest in the pathophysiology of schizophrenia. ME...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00109-2

    authors： Lindström LH,Gefvert O,Hagberg G,Lundberg T,Bergström M,Hartvig P,Långström B

    更新日期：1999-09-01 00:00:00

  • Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder.

    abstract：:The male bias in autism spectrum disorder incidence is among the most extreme of all neuropsychiatric disorders, yet the origins of the sex difference remain obscure. Developmentally, males are exposed to high levels of testosterone and its byproduct, estradiol. Together these steroids modify the course of brain devel...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2016.10.004

    authors： McCarthy MM,Wright CL

    更新日期：2017-03-01 00:00:00

  • Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder.

    abstract：BACKGROUND:Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms. METHODS:Twenty-four children between the ages of 7 ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01218-5

    authors： Carrion VG,Weems CF,Eliez S,Patwardhan A,Brown W,Ray RD,Reiss AL

    更新日期：2001-12-15 00:00:00

  • P300 subcomponent abnormalities in schizophrenia: III. Deficits In unaffected siblings of schizophrenic probands.

    abstract：BACKGROUND:Reduced P300 amplitude is a robust finding in patients with schizophrenia. In previous investigations, we reported reductions of specific subcomponents of the auditory oddball P300 that were independent of acute symptomatology and persistent over time, consistent with a trait abnormality. To clarify whether ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00290-5

    authors： Turetsky BI,Cannon TD,Gur RE

    更新日期：2000-03-01 00:00:00

  • High dose naloxone in depression.

    abstract：:The behavioral effects of a 2 mg/kg iv bolus infusion of naloxone were compared with a placebo infusion using a double-blind design in a small group of inpatient depressives (n = 6) and normals (n = 8). Naloxone produced consistent and significant worsening in the rated signs and subjective symptoms of depression in t...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：

    authors： Cohen MR,Cohen RM,Pickar D,Sunderland T,Mueller EA 3rd,Murphy DL

    更新日期：1984-06-01 00:00:00

  • Meeting report; "Molecular neurobiological mechanisms in schizophrenia: seeking a synthesis," April 11-14, 1999.

    abstract：:A meeting on the molecular and neurobiological basis of schizophrenia was held April 11-14, 1999 at the Banbury Center of The Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. This report is a summary of the predominant views of the participants, as perceived by the organizers. The purpose of this meeting w...

    journal_title：Biological psychiatry

    pub_type：

    doi：10.1016/s0006-3223(00)00904-5

    authors： Goodman AB,Pardee AB

    更新日期：2000-08-01 00:00:00

  • Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activity.

    abstract：BACKGROUND:We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD). METHODS:Positron emission tomography with [(15)O] water measured alterations of regional cerebral blood flow (rCBF) d...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2004.07.011

    authors： Schweitzer JB,Lee DO,Hanford RB,Zink CF,Ely TD,Tagamets MA,Hoffman JM,Grafton ST,Kilts CD

    更新日期：2004-10-15 00:00:00

  • An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism.

    abstract：BACKGROUND:Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.11.010

    authors： Meziane H,Schaller F,Bauer S,Villard C,Matarazzo V,Riet F,Guillon G,Lafitte D,Desarmenien MG,Tauber M,Muscatelli F

    更新日期：2015-07-15 00:00:00

  • Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2.

    abstract：BACKGROUND:Association analysis identified the homeobox transcription factor, ENGRAILED 2 (EN2), as a possible autism spectrum disorder (ASD) susceptibility gene (ASD [MIM 608636]; EN2 [MIM 131310]). The common alleles (underlined) of two intronic single nucleotide polymorphisms (SNPs), rs1861972 (A/G) and rs1861973 (C...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.05.027

    authors： Benayed R,Choi J,Matteson PG,Gharani N,Kamdar S,Brzustowicz LM,Millonig JH

    更新日期：2009-11-15 00:00:00

  • Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study.

    abstract：BACKGROUND:Patients with bipolar disorder have been reported to have abnormal cortical function during mania. In this study, we sought to investigate neural activity in the frontal lobe during mania, using functional magnetic resonance imaging (fMRI). Specifically, we sought to evaluate activation in the lateral orbito...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.09.012

    authors： Altshuler LL,Bookheimer SY,Townsend J,Proenza MA,Eisenberger N,Sabb F,Mintz J,Cohen MS

    更新日期：2005-11-15 00:00:00