Abstract:
BACKGROUND:Most depressed adults exhibit dysregulation of the hypothalamic-pituitary-adrenal axis, including cortisol hyperreactivity to psychosocial challenge. In contrast, remarkably little is known about hypothalamic-pituitary-adrenal axis activity in response to psychosocial challenge among at-risk children and adolescents. This study examined cortisol response to psychosocial challenge in nondepressed, at-risk, dysphoric and nondysphoric control youth across different developmentally salient age groups (preschool, third-, sixth-, and ninth-graders). METHODS:Two samples of youth (Study 1-preschoolers; Study 2-third-, sixth-, and ninth-graders) without a history of clinical depression were administered developmentally appropriate psychosocial challenges. Of these nondepressed children, we examined youth at high-risk (n = 60) and low-risk (n = 223) status, as defined by elevated but subthreshold dysphoric symptoms according to multiple informants. Cortisol levels were assessed before and after a psychosocial stressor. RESULTS:Nondysphoric control youth at all ages displayed the expected cortisol rise to challenge followed by return to baseline. However, prepubertal, at-risk, dysphoric children--specifically preschoolers and third-graders--exhibited cortisol hyporeactivity to challenge, whereas postpubertal dysphoric adolescents (ninth-graders) displayed hyperreactivity to the stressor. Additional analyses revealed that this switch from cortisol hyporeactivity to hyperreactivity among at-risk, dysphoric youth occurred as a function of pubertal development. CONCLUSIONS:Findings suggest a developmental switch in cortisol response for at-risk, dysphoric youth from preschool through adolescence and have implications for a developmental pathophysiological understanding of how at-risk youth across the lifespan might develop depressive disorder.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Hankin BL,Badanes LS,Abela JR,Watamura SEdoi
10.1016/j.biopsych.2010.04.004subject
Has Abstractpub_date
2010-09-01 00:00:00pages
484-90issue
5eissn
0006-3223issn
1873-2402pii
S0006-3223(10)00348-3journal_volume
68pub_type
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,meta分析
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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