Abstract：
BACKGROUND:Effects of the hypothalamic-pituitary-adrenal (HPA) axis on central dopaminergic systems have been proposed to underlie the development of psychotic symptoms in depression. This study examined HPA axis hormone effects on plasma levels of homovanillic acid (HVA), the dopamine metabolite, in healthy volunteers, using a placebo-controlled, double-blind, random-assignment, crossover design. On the basis of preliminary studies, we hypothesized that HPA axis hormones would produce delayed effects on plasma HVA levels measured in the afternoon. METHODS:Ten healthy subjects underwent a standard protocol on four occasions and each time received ovine corticotropin-releasing hormone, synthetic adrenocorticotropic hormone (ACTH), cortisol, or placebo. Plasma HVA was measured at 9 AM and 4 PM on Day 1, immediately prior to administration of the test substance at 7 PM, then at 30-60-min intervals until 11 PM. Plasma HVA levels were subsequently obtained at 9 AM and 4 PM on Days 2 and 3. RESULTS:As predicted, there were significant differences between test substances in delayed effects on afternoon HVA levels measured on Days 2 and 3, with cortisol and ACTH producing greater increases in HVA than placebo. Acute effects of HPA axis hormones on HVA were not found, while differences between test substances in delayed effects on morning HVA levels approached significance. CONCLUSIONS:HPA axis hormones exert delayed effects on plasma HVA levels in healthy humans.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Posener JA,Schatzberg AF,Williams GH,Samson JA,McHale NL,Bessette MP,Schildkraut JJdoi
10.1016/s0006-3223(97)00550-7subject
Has Abstractpub_date
1999-01-15 00:00:00pages
222-8issue
2eissn
0006-3223issn
1873-2402pii
S0006-3223(97)00550-7journal_volume
45pub_type
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