Abstract：
:This study examined the relationship between borderline and impulsive personality traits on the one hand, and monoamine function on the other in 15 women with bulimia nervosa and 15 women with recurrent suicidal behavior. Platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were used as peripheral measures of monoaminergic function. All suicide attempters were diagnosed as having a borderline personality disorder, whereas this diagnosis was less frequent in bulimics. Bulimics with borderline comorbidity resembled recurrent suicide attempters with borderline personality disorder more closely in both psychological (anger, impulsive behavior) and biochemical characteristics (platelet 5-HT) than bulimics without borderline personality disorder. Platelet 5-HT was higher in patients with borderline personality than in normal female controls and was positively correlated with the disposition to experience anger. Impulsive personality traits were consistently negatively correlated with platelet MAO activity. Our findings support the subdivision of bulimics according to the presence of borderline or "multi-impulsive" personality disorder.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Verkes RJ,Pijl H,Meinders AE,Van Kempen GMdoi
10.1016/0006-3223(95)00384-3subject
Has Abstractpub_date
1996-08-01 00:00:00pages
173-80issue
3eissn
0006-3223issn
1873-2402pii
0006-3223(95)00384-3journal_volume
40pub_type
杂志文章abstract：:Specific psychiatric disorders are characterized by impaired selective inhibition or "gating" of responses to sensory or cognitive information. Less is known about gating differences among normal individuals. We tested carefully screened controls in measures of central inhibition: prepulse inhibition (PPI) of startle,...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)00138-S
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.11.010
更新日期：2015-07-15 00:00:00
abstract：BACKGROUND:Considering that platelets have been established to be good peripheral markers for the study of catecholaminergic neurons, we have applied an assay to measure the uptake of (3H)-dopamine (DA) into platelet storage granules (PSG). Recently, we reported that Tourette's syndrome (TS) patients (pts) show decreas...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00476-9
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Traumatic experiences for young children might result in profound neurodevelopmental changes, compared with adults. Our aim was to examine autonomic control of heart rate in traumatized young children. METHODS:Sixty-two children who had suffered traumas and 62 nontraumatized control children, aged 20 months...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.01.006
更新日期：2004-04-01 00:00:00
abstract：:The categorical approach to defining schizophrenia spectrum disorders requires meeting established criteria. To advance early identification and intervention in young people, the field has progressed to studying help-seeking individuals who are at clinical high risk based on subthreshold psychosis spectrum symptoms, a...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2020.02.002
更新日期：2020-08-15 00:00:00
abstract：BACKGROUND:In addition to cognitive impairment, there are disruptions to mood and emotion processing in attention-deficit/hyperactivity disorder (ADHD) but little is known about their neural basis. We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment wit...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.11.022
更新日期：2008-05-15 00:00:00
abstract：BACKGROUND:Our study described the neuropsychological profile of psychotic major depression (PMD) compared to nonpsychotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits. METHODS:Twenty-nine PMDs, ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.11.010
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Prior neurophysiological studies on patients with premenstrual syndrome (PMS) have revealed sleep electroencephalographic alterations in both cycle phases. We report on a study evaluating saccadic eye movements in PMS patients. METHODS:Saccadic eye movements were examined in 21 women with and 21 women witho...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(98)00012-2
更新日期：1998-10-15 00:00:00
abstract：BACKGROUND:Impulsive aggression in patients with personality disorders is associated with diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to serotonergic agonists, and decreased glucose utilization in the prefrontal cortex. We tested the hypothesis that impulsive aggression in bo...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(99)00202-4
更新日期：2000-03-15 00:00:00
abstract：BACKGROUND:Functional neuroimaging studies of bipolar disorder (BD) performed in conjunction with antidepressant treatment trials generally require that patients remain on mood stabilizers to reduce the risk of inducing mania; yet, it is unknown whether the metabolic abnormalities evident in unmedicated BD depressives ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.06.009
更新日期：2007-03-15 00:00:00
abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by deficits in attention, increased motor impulsivity, and hyperactivity. Preliminary work in mice and humans has suggested the X-linked gene STS (which encodes the enzyme steroid sulfatase) as a mediator o...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.01.001
更新日期：2009-08-15 00:00:00
abstract：BACKGROUND:Cannabis use is associated with an increased risk of psychosis. One study has suggested that genetic variation in the AKT1 gene might influence this effect. METHODS:In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.06.020
更新日期：2012-11-15 00:00:00
abstract：BACKGROUND:We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders. METHODS:DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples...
journal_title：Biological psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2005.01.030
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.02.019
更新日期：2008-09-01 00:00:00
abstract：:Sleep homeostasis and circadian function are important maintaining factors for optimal health and well-being. Conversely, sleep and circadian disruptions are implicated in a variety of adverse health outcomes, including substance use disorders. These risks are particularly salient during adolescence. Adolescents requi...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2017.11.035
更新日期：2018-06-15 00:00:00
abstract：BACKGROUND:The antidepressant-like effects of brain-derived neurotrophic factor (BDNF) infusions in brain, and the upregulation of BDNF mRNA and its receptor in rats exposed to electroconvulsive seizure (ECS) and antidepressants, suggested a role for increased BDNF protein. METHODS:We measured BDNF protein levels with...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00073-8
更新日期：2003-10-01 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the ra...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90420-7
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:The search for susceptibility genes in autism and autism spectrum disorders (ASD) has been hindered by the possible small effects of individual genes and by genetic (locus) heterogeneity. To overcome these obstacles, one method is to use autism-related subphenotypes instead of the categorical diagnosis of au...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.05.023
更新日期：2008-10-01 00:00:00
abstract：:Several findings support the hypothesis that the striatum is implicated in executive functions and in the modulation of goal-directed behavior, and could play a key role in the pathophysiology and in the production of symptoms and signs in schizophrenia. We have studied the relationship between the objective measures ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00017-6
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:There is amassing evidence that risky decision-making in bipolar disorder is related to reward-based differences in frontostriatal regions. However, the roles of early attentional and later cognitive processes remain unclear, limiting theoretical understanding and development of targeted interventions. METH...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2015.03.014
更新日期：2016-02-15 00:00:00
abstract：:To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for ...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(03)00171-9
更新日期：2003-09-01 00:00:00
abstract：:Acute Intermittent Porphyria (AIP) is an autosomal dominant metabolic disorder that has various psychiatric manifestations. This is a report of a case who had six brief psychotic episodes of varying nature within a 2-month period. The psychotic manifestations included catatonic stupor, hypomania, and delirium in diffe...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)90085-x
更新日期：1994-12-01 00:00:00
abstract：:Extensive work in the field has indicated a state-dependent hyperactivity of the hypothalamic-pituitary-adrenocortical (HYPAC) functions and unresponsiveness to dexamethasone suppression in at least 50% of patients suffering from endogenous depression. In this study, elderly outpatients, 60-85 years of age, suffering ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：BACKGROUND:Brattleboro rats (BRATs) have natural deficits in prepulse inhibition (PPI) of the startle response similar to those exhibited by schizophrenia patients, which are reversed by antipsychotics. We sought to determine whether they also have increases in striatal dopamine-2 (D2) receptors found in some studies e...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.03.045
更新日期：2006-12-01 00:00:00
abstract：:Functional neuroimaging studies have identified multiple nodes of dysfunction in frontostriatal and mesocorticolimbic networks in attention-deficit/hyperactivity disorder (ADHD). Yet relatively few studies have examined how structural and functional connectivity between nodes in these networks might relate to the beha...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2011.03.022
更新日期：2011-06-15 00:00:00
abstract：BACKGROUND:There is increasing evidence for an association between alterations of brain glutamatergic neurotransmission and the pathophysiology of affective disorders. METHODS:We studied the association between cerebrospinal fluid (CSF) metabolites, including glutamine, in unipolar and bipolar depressed patients versu...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00284-x
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Reduction in a pre-attentive measure of auditory change detection, mismatch negativity (MMN), is one of the most consistent findings in schizophrenia. Recently, our group showed a reduction in MMN to changes in the duration and intensity of background sounds in those within 5 years of illness onset, whereas ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.08.023
更新日期：2012-01-15 00:00:00
abstract：BACKGROUND:Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are likely involved in fine motor skill and specifically motor learning. However, the role of these conn...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.06.020
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Difficulty with impulse control is heightened in children with a family history of alcohol use disorders and is a risk factor for later substance problems. Cross-sectional functional magnetic resonance imaging studies have shown altered impulse control processing in adolescents with a positive family history...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.03.005
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:The hippocampus is likely involved in mood disorders, but in vivo evidence for the role of anatomically distinct hippocampal subregions is lacking. Multiple sclerosis, an inflammatory disease of the central nervous system, is linked to a high prevalence of depression as well as hippocampal damage and may thu...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.04.025
更新日期：2010-09-15 00:00:00
