Abstract：
:Seven women with histories of puerperal psychosis and four with histories of puerperal major depression were consecutively treated with high-dose oral estrogen immediately following delivery. None of the women had histories of nonpuerperal affective disorder, and all women were affectively well throughout the current pregnancy and at delivery. Despite the high risk for recurrent illness in this population, only one woman developed relapse of postpartum affective disorder. All others remained entirely well and required no treatment with psychotropic medications during the 1 year follow-up period. This low rate of relapse, 9% compared to an expected 35-60% without prophylaxis, suggests that oral estrogen may stem the rapid rate of change in estrogen following delivery, thereby preventing the potential impact on dopaminergic and serotonergic neuroreceptors. It is hypothesized that the rapid rate of change of estrogen after delivery creates an "estrogen withdrawal state." This may be a critical factor in driving acute puerperal affective psychosis and early-onset puerperal major depression.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Sichel DA,Cohen LS,Robertson LM,Ruttenberg A,Rosenbaum JFdoi
10.1016/0006-3223(95)00063-1subject
Has Abstractpub_date
1995-12-15 00:00:00pages
814-8issue
12eissn
0006-3223issn
1873-2402pii
0006-3223(95)00063-1journal_volume
38pub_type
杂志文章abstract：BACKGROUND:Children with early-onset disruptive behavior disorder (DBD), especially those with callous-unemotional traits, are at risk of developing persistent and severe adult antisocial behavior. One possible underlying mechanism for persistence is deficient reward and loss sensitivity, i.e., deficient incentive proc...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.08.017
更新日期：2015-11-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1989-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：1991-08-15 00:00:00
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pub_type： 杂志文章
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更新日期：1998-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2017-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1999-12-01 00:00:00
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更新日期：2006-09-01 00:00:00
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更新日期：2000-11-15 00:00:00
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pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.10.012
更新日期：2013-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.08.011
更新日期：2009-01-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00029-8
更新日期：1998-10-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.biopsych.2005.02.012
更新日期：2005-07-15 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(01)01133-7
更新日期：2001-07-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2017.06.013
更新日期：2017-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
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更新日期：2009-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.03.061
更新日期：2006-10-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90195-j
更新日期：1993-10-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90077-q
更新日期：1993-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1980-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.12.015
更新日期：2004-04-15 00:00:00
