Abstract：
BACKGROUND:Early emerging characteristics of visual orienting have been associated with a wide range of typical and atypical developmental outcomes. In the current study, we examined the development of visual disengagement in infants at risk for autism. METHODS:We measured the efficiency of disengaging from a central visual stimulus to orient to a peripheral one in a cohort of 104 infants with and without familial risk for autism by virtue of having an older sibling with autism. RESULTS:At 7 months of age, disengagement was not robustly associated with later diagnostic outcomes. However, by 14 months, longer latencies to disengage in the subset of the risk group later diagnosed with autism was observed relative to other infants at risk and the low-risk control group. Moreover, between 7 months and 14 months, infants who were later diagnosed with autism at 36 months showed no consistent increases in the speed and flexibility of visual orienting. However, the latter developmental effect also characterized those infants who exhibited some form of developmental concerns (but not meeting criteria for autism) at 36 months. CONCLUSIONS:Infants who develop autism or other developmental concerns show atypicality in the development of visual attention skills from the first year of life.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Elsabbagh M,Fernandes J,Webb SJ,Dawson G,Charman T,Johnson MH,British Autism Study of Infant Siblings Team.doi
10.1016/j.biopsych.2012.11.030subject
Has Abstractpub_date
2013-08-01 00:00:00pages
189-94issue
3eissn
0006-3223issn
1873-2402pii
S0006-3223(12)01086-4journal_volume
74pub_type
杂志文章abstract：BACKGROUND:Anatomic magnetic resonance imaging (MRI) studies of attention-deficit/hyperactivity disorder (ADHD) have been limited by use of callosal rather than sulcal/gyral landmarks in defining cerebral lobes and functionally relevant sublobar regions (e.g., prefrontal cortex). We present an investigation of cerebral...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01412-9
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
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更新日期：1990-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2004-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
