Abstract：
:Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity for nonsuppression to the DST was 36.0%, whereas that for blunted thyroid-stimulating hormone (TSH) response to TRH was 28.0%. Both DST nonsuppression and TSH blunting appeared to be state-related markers for depressed patients. Specifically, a significant increase of maximum TSH response to TRH after 4 weeks of antidepressant therapy was associated with clinical improvement. Plasma TRH-LI in depressed patients was significantly lower than that of healthy controls. It is possible that the lower plasma TRH-LI level is related to the pathophysiology of some depressed patients with major affective disorders.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Itoh N,Matsui N,Fuwano S,Yaginuma H,Miyashita O,Sakai Mdoi
10.1016/0006-3223(87)90184-3subject
Has Abstractpub_date
1987-05-01 00:00:00pages
559-72issue
5eissn
0006-3223issn
1873-2402pii
0006-3223(87)90184-3journal_volume
22pub_type
杂志文章abstract：BACKGROUND:Consistent with the fetal programming hypothesis, effects of maternal prenatal anxiety have been found to predict various measures of infant temperament in the early postnatal period. In recent years, a polymorphism in the serotonin transporter gene (5-HTTLPR) emerged as a moderator of diverse environmental ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.10.006
更新日期：2011-03-15 00:00:00
abstract：:Learned helplessness is a behavioral condition induced by exposure to inescapable stress that models aspects of stress-related disorders including depression and posttraumatic stress disorder, and has been associated with diminished serotonin release in the rat frontal cortex. Our hypothesis was that presynaptic 5-hyd...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(96)00114-X
更新日期：1997-03-15 00:00:00
abstract：:The dexamethasone suppression test (DST) and sleep EEG were compared in three different descriptive diagnostic schemes in 70 adult patients with nonpsychotic, unipolar major depressive disorder according to Research Diagnostic Criteria. Endogenous (E)/nonendogenous (NE), primary/secondary, and Winokur's family history...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.06.007
更新日期：2008-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2017.05.026
更新日期：2018-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type：
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更新日期：2000-08-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01228-8
更新日期：2002-05-01 00:00:00
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journal_title：Biological psychiatry
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更新日期：1999-04-15 00:00:00
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journal_title：Biological psychiatry
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更新日期：2002-09-15 00:00:00
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journal_title：Biological psychiatry
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更新日期：2005-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-05-15 00:00:00
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更新日期：2011-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0006-3223(95)00063-1
更新日期：1995-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.04.017
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.03.026
更新日期：2011-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1985-07-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1985-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2003-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.07.025
更新日期：2015-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2014-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.04.006
更新日期：2012-09-01 00:00:00
