Abstract：
:Schizophrenia is a debilitating mental illness that affects approximately 1% of the world's population. Despite much research in its neurobiology to aid in developing new treatments, little progress has been made. One system that has not received adequate attention is the kappa opioid system and its potential role in the emergence of symptoms, as well as its therapeutic potential. Here we present an overview of the kappa system and review various lines of evidence derived from clinical studies for dynorphin and kappa opioid receptor involvement in the pathology of both the positive and negative symptoms of schizophrenia. This overview includes evidence for the psychotomimetic effects of kappa opioid receptor agonists in healthy volunteers and their reversal by the pan-opioid antagonists naloxone and naltrexone and evidence for a therapeutic benefit in schizophrenia for 4 pan-opioid antagonists. We describe the interactions between kappa opioid receptors and the dopaminergic pathways that are disrupted in schizophrenia and the histologic evidence suggesting abnormal kappa opioid receptor signaling in schizophrenia. We conclude by discussing future directions.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Clark SD,Abi-Dargham Adoi
10.1016/j.biopsych.2019.05.012subject
Has Abstractpub_date
2019-10-01 00:00:00pages
502-511issue
7eissn
0006-3223issn
1873-2402pii
S0006-3223(19)31379-4journal_volume
86pub_type
杂志文章,评审abstract：:The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produce...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2017.03.012
更新日期：2017-10-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00294-4
更新日期：2003-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01400-2
更新日期：2002-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00082-1
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01350-1
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(95)00672-9
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.08.013
更新日期：2004-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.05.007
更新日期：2008-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)00915-x
更新日期：2000-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01728-6
更新日期：2003-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.06.021
更新日期：2009-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.12.025
更新日期：2017-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90080-7
更新日期：1988-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.biopsych.2005.01.041
更新日期：2005-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.07.009
更新日期：2011-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90091-y
更新日期：1991-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90231-n
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.09.016
更新日期：2004-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.10.045
更新日期：2009-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90263-1
更新日期：1989-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.10.008
更新日期：2008-05-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2019.08.028
更新日期：2020-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.11.017
更新日期：2006-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90102-3
更新日期：1988-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0006-3223(88)90003-0
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2015-12-15 00:00:00
