Abstract：
BACKGROUND:Patients with schizophrenia have an increased risk over the general public of developing cardiovascular illness. It is unknown if there are functional changes in platelet surface receptors in schizophrenia. We therefore analyzed the surface expression of glycoprotein (GP)Ib, the integrin receptor alpha(IIb)beta(IIIa), CD62 (P-selectin), and CD63, and investigated platelet function in schizophrenic patients compared with healthy volunteers. METHODS:Nineteen drug-naive, first-episode patients with a DSM IV diagnosis of paranoid schizophrenia were compared with matched healthy controls. Flow cytometry was used to assess platelet surface expression levels of GPIb, alpha(IIb)beta(IIIa), CD62, and CD63. Adenosine diphosphate-induced platelet aggregation was assayed. RESULTS:The schizophrenic patients had a significantly (p < .0001) increased number of 68,145 +/- 8,260.1 alpha(IIb)beta(IIIa) receptors, platelet compared with 56,235 +/- 8,079.4 receptors, platelet in healthy controls. CONCLUSIONS:Patients with schizophrenia have increased platelet expression of alpha(IIb)beta(IIIa), which may contribute to their increased risk of cardiovascular illness compared with the general population.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Walsh MT,Ryan M,Hillmann A,Condren R,Kenny D,Dinan T,Thakore JHdoi
10.1016/s0006-3223(02)01400-2subject
Has Abstractpub_date
2002-11-01 00:00:00pages
874-9issue
9eissn
0006-3223issn
1873-2402pii
S0006322302014002journal_volume
52pub_type
杂志文章abstract：BACKGROUND:Previous reports of ventricular and hippocampal volumes in patients with bipolar disorder (BP) have been inconsistent in their findings. One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two...
journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：
更新日期：1975-08-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.11.004
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2013-09-15 00:00:00
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pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2005.01.030
更新日期：2005-05-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00697-8
更新日期：2003-12-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.03.017
更新日期：2010-07-15 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：2009-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2015-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90184-3
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2000-10-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90033-9
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00459-9
更新日期：1999-05-15 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-10-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00023-2
更新日期：1999-08-15 00:00:00
