Abstract:
:It has been proposed that the nailfold subpapillary plexus visibility score (PVS) may be a marker of susceptibility to schizophrenia. To further investigate this hypothesis, we evaluated plexus visibility in a sample of 61 chronic schizophrenics, a large sample of first-episode psychotic patients and their first-degree relatives (50 with schizophrenia, and 51 of their relatives; 29 with schizophreniform disorder, 30 of their relatives; 32 with major depression with psychotic features, 35 of their relatives; 33 with a bipolar disorder with psychotic features, 32 of their relatives), and 169 normal control subjects. Group comparisons demonstrated that (1) the probands with chronic schizophrenia, first episode schizophrenia, and schizophreniform disorder did not differ from one another on PVS; (2) these subjects combined had higher PVS ratings than the other two proband groups and normal subjects combined (who did not differ); and (3) none of the relative groups significantly differed from either one another or the normal subjects. On the other hand, relatives of schizophrenia spectrum probands with high PVS (greater than or equal to 10.0) had higher PVS ratings than the relatives of such probands with low PVS. Patterns of familial correlations suggested that PVS was moderately heritable (0.40). There was no evidence that nonadditive genetic variation influenced the trait.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Clementz BA,Iacono WG,Ficken J,Beiser Mdoi
10.1016/0006-3223(92)90231-nsubject
Has Abstractpub_date
1992-02-15 00:00:00pages
378-90issue
4eissn
0006-3223issn
1873-2402pii
0006-3223(92)90231-Njournal_volume
31pub_type
杂志文章abstract::There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain extinction memory over time (i.e., extinction retention). We argue that there are still important conceptual and procedural cha...
journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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更新日期:2019-03-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1999-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
更新日期:1980-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:2000-06-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/0006-3223(90)90007-o
更新日期:1990-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.biopsych.2005.01.041
更新日期:2005-05-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-06-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2020.10.009
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1995-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2013-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90060-d
更新日期:1992-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1990-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2013-08-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90187-5
更新日期:1992-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2018.06.014
更新日期:2019-01-15 00:00:00