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The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar disorder I and its clinical correlates.

Abstract：

BACKGROUND:Cognitive abnormalities are increasingly recognized as a feature of bipolar I disorder (BDI,) but there is limited information regarding the pattern and severity of cognitive impairment during remission and its relationship with clinical variables. METHODS:Forty-four remitted BDI patients recruited from a representative treatment sample and an equal number of matched healthy volunteers underwent comprehensive clinical and cognitive assessments. Cognitive evaluation covered the domains of IQ, memory, and executive function. The profile of cognitive deficits in patients was examined, and the correlation of executive function with clinical features and treatment variables was explored. RESULTS:Remitted BDI patients were impaired in tests of executive function compared with healthy participants. Within the patient group, current antipsychotic treatment predicted worse performance across all executive function tests, whereas duration of illness predicted loss of inhibitory control. Residual mood symptoms, regardless of polarity, had a negative impact primarily on measures of attentional interference. CONCLUSIONS:These results suggest that impaired executive function might be an important feature of BDI. Antipsychotic treatment, duration of illness, and level of symptoms are the most significant contributors to the observed impairment.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Frangou S,Donaldson S,Hadjulis M,Landau S,Goldstein LH

doi

10.1016/j.biopsych.2005.04.056

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

859-64

issue

11

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(05)00579-2

journal_volume

58

pub_type

临床试验,杂志文章

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