Abstract：
:EEGs were recorded for two groups of chronic alcoholics who scored at opposite extremes on the Shipley Institute of Living Scale. The groups were matched in terms of age and drinking history variables and were compared to age-matched control subjects for left and right precentral (F-T) and postcentral (C-O) placements. Significant ANOVA findings were obtained primarily in high-frequency bands in the three group comparison. A significant linear trend was found for power as a function of degree of impairment from controls to moderately impaired alcoholics to severely impaired alcoholics in frequency bands above 14 Hz. The trend was most pronounced in the F-T derivations. Implications of the findings with respect to cortical atrophy in alcoholism are discussed.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Coger RW,Dymond AM,Serafetinides EA,Lowenstam I,Pearson Dsubject
Has Abstractpub_date
1978-12-01 00:00:00pages
729-39issue
6eissn
0006-3223issn
1873-2402journal_volume
13pub_type
杂志文章abstract：:Acute Intermittent Porphyria (AIP) is an autosomal dominant metabolic disorder that has various psychiatric manifestations. This is a report of a case who had six brief psychotic episodes of varying nature within a 2-month period. The psychotic manifestations included catatonic stupor, hypomania, and delirium in diffe...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)90085-x
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:Striatal enlargement with chronic neuroleptic treatment in schizophrenic patients has been reported by several investigators. Longitudinal magnetic resonance imaging studies of patients suggest that changes in striatal volume may be caused by treatment with antipsychotic medication. METHODS:We have examined...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00029-8
更新日期：1998-10-15 00:00:00
abstract：BACKGROUND:The anterior cingulate and medial prefrontal cortex play an important role in the inhibition of responses, as measured by the Stroop task, as well as in emotional regulation. Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpos...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.10.001
更新日期：2004-03-15 00:00:00
abstract：BACKGROUND:Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease. However, it remains unclear whether upregulated...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.03.020
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The antidepressant-like effects of brain-derived neurotrophic factor (BDNF) infusions in brain, and the upregulation of BDNF mRNA and its receptor in rats exposed to electroconvulsive seizure (ECS) and antidepressants, suggested a role for increased BDNF protein. METHODS:We measured BDNF protein levels with...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00073-8
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:In the Systematic Treatment Enhancement Program for Bipolar Disorder, we showed that valproate is associated with new-onset menstrual-cycle irregularities and hyperandrogenism in 10.5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation. ME...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.05.027
更新日期：2006-12-15 00:00:00
abstract：:Research on mood and anxiety disorders has historically proceeded without sufficient reference to the growing body of work on the nature of typical emotional development and temperament. Reviewing data from several studies, we consider experiential, biological, and genetic factors as providing causal input to typical ...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(00)01003-9
更新日期：2000-12-15 00:00:00
abstract：:A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-charac...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(96)00297-1
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:The hippocampus is likely involved in mood disorders, but in vivo evidence for the role of anatomically distinct hippocampal subregions is lacking. Multiple sclerosis, an inflammatory disease of the central nervous system, is linked to a high prevalence of depression as well as hippocampal damage and may thu...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.04.025
更新日期：2010-09-15 00:00:00
abstract：:Short-term reduction in plasma tryptophan (tryptophan depletion) produces a relapse of depressive symptoms in 60% of previously depressed patients recently recovered with serotonin reuptake inhibitor treatment. Tryptophan depletion does not consistently increase depressive symptoms in unmedicated depressed patients or...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0006-3223(96)00224-7
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:The medial prefrontal cortex (mPFC) subserves complex cognition and is impaired by stress. Corticotropin-releasing factor (CRF), through CRF receptor 1 (CRFR1), constitutes a key element of the stress response. However, its contribution to the effects of stress in the mPFC remains unclear. METHODS:Mice were...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.03.2106
更新日期：2016-11-15 00:00:00
abstract：:The relationship between plasma kynurenine (KYN) concentration and anxiety and depression in psychiatric patients was examined. KYN has been reported as a probable endogenous anxiogen in animal models of anxiety. Thirty patients with affective states were studied. The Hamilton Anxiety Scale (HAM-A), Hamilton Depressio...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0006-3223(94)91189-4
更新日期：1994-07-15 00:00:00
abstract：BACKGROUND:No objective diagnostic biomarkers or laboratory tests have yet been developed for psychotic illness. Magnetic resonance imaging (MRI) studies consistently find significant abnormalities in multiple brain structures in psychotic patients relative to healthy control subjects, but these abnormalities show subs...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.07.019
更新日期：2009-12-01 00:00:00
abstract：:We have recently reported that acute administration of cocaine to rats alters their sensory inhibitory capacity as tested in a paired click paradigm (S1/S2). Whether such acutely induced changes are persistent, is not known. In order to shed some light on the degree of spontaneous reversibility of cocaine-induced decr...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(96)00057-1
更新日期：1997-02-15 00:00:00
abstract：BACKGROUND:Relations between stress hormones and antisocial behavior are understudied. METHODS:A subsample (n = 335) of at-risk males recruited in first grade for a longitudinal study were recruited at approximately 16 years of age for a laboratory study, including two psychological challenges: describing their worst ...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.biopsych.2005.01.041
更新日期：2005-05-15 00:00:00
abstract：:There is indirect evidence that smoking induces higher enzymatic activity which accelerates the metabolism of many drugs. This influence is inferred from the frequency and magnitude of drug side effects. We could demonstrate that smokers need higher doses of neuroleptic drugs than nonsmokers. ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:Genetic studies of schizophrenia have implicated numerous risk loci including several copy number variants (CNVs) of large effect and hundreds of loci of small effect. In only a few cases has a specific gene been clearly identified. Rare CNVs affecting a single gene offer a potential avenue to discovering sc...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.09.023
更新日期：2020-04-15 00:00:00
abstract：:It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. It is clear that the interaction between genetic predisposition and early life environment...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2018.06.014
更新日期：2019-01-15 00:00:00
abstract：BACKGROUND:Long term medication with antipsychotic drugs is known to produce changes in neurotransmitter levels and receptor sensitivity in the cortex; however, the anatomic consequences of chronic antipsychotic exposure are not well established. METHODS:Accordingly, rhesus monkeys were given daily oral doses of typic...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00113-4
更新日期：1999-07-15 00:00:00
abstract：BACKGROUND:A genetic component has a role in the etiology of Panic Disorder (PD) and a familial association between PD and CO2 hypersensitivity have been repeatedly described. METHODS:Complex segregation analysis was performed on a sample of 165 families of PD probands and on the subgroup homogeneous for CO2 hypersens...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00004-9
更新日期：1999-09-15 00:00:00
abstract：:A group of 29 bipolar manic-depressives completed a 12-month double-blind cross-over trial of low-dose and high-dose lithium prophylaxis. Twelve patients relapsed, and significantly more of the relapses occurred during the low-dose 6-month phase of the trial. There was a trend for relapse to occur within 2 months of a...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the ra...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90420-7
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Multiple neuropsychiatric disorders, e.g., depression, are linked to imbalances in excitatory and inhibitory neurotransmission and prefrontal cortical dysfunction, and are concomitant with chronic stress. METHODS:We used electrophysiologic (n = 5-6 animals, 21-25 cells/group), neuroanatomic (n = 6-8/group),...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.03.2101
更新日期：2016-11-15 00:00:00
abstract：:The evidence that catecholestrogens are formed in the brain and exert behavioral effects in animal models suggest that these steroids might have psychotropic activities. In the present investigation, the formation and metabolism of catecholestrogens were studied in depressed patients. Twenty-four-hr urine samples were...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90455-b
更新日期：1990-10-15 00:00:00
abstract：BACKGROUND:A large number of studies suggest the presence of deficits in dorsolateral prefrontal cortex function during performance of working memory tasks in individuals with schizophrenia. However, working memory deficits may also present in other psychiatric disorders, such as major depression. It is not clear wheth...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01674-8
更新日期：2003-03-01 00:00:00
abstract：:Using magnetic resonance imaging (MRI), we measured the volumes of various brain structures and cerebrospinal fluid (CSF) in 19 men with dementia of the Alzheimer type (DAT) and 18 healthy age-matched control men. The mean (+/- S.D) Mini-Mental State exam score (MMSE) of the DAT men was 16 +/- 7; 9 were mildly (MMSE >...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90153-5
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:The amplitude of the auditory P3 event-related potential is reduced in patients with axes I and II disorders. Data regarding P3 amplitude and normal personality traits in healthy individuals have been inconsistent, however, although more extreme variants of dimensional traits such as neuroticism and extraver...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)01067-2
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Investigators have reported lack of normal asymmetry of lateralization in some schizophrenic patients, as measured postmortem and by preference and/or performance. It has been suggested that this lack of asymmetry is related to early onset of schizophrenia. The present study extends the inquiry by magnetic r...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(98)00076-6
更新日期：1998-09-15 00:00:00
abstract：:Abnormalities in circadian rhythms of core body temperature have been reported previously in depressed patients. In this study, we compared the temperature rhythms of 10 depressed seasonal affective disorder (SAD) patients with winter depression with those of 12 normal controls and evaluated the effects of bright ligh...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90018-w
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Suicide is a major risk for those with bipolar disorder, a risk amplified by comorbid substance abuse in some, but not all, previous studies. To further explore the relationships of substance abuse, suicide, and bipolarity as they present in clinical practice, we analyzed standardized clinical data from a la...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.10.003
更新日期：2004-11-15 00:00:00
