Abstract：
BACKGROUND:The anterior cingulate and medial prefrontal cortex play an important role in the inhibition of responses, as measured by the Stroop task, as well as in emotional regulation. Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpose of this study was to use the Stroop task as a probe of anterior cingulate function in PTSD. METHODS:Women with early childhood sexual abuse-related PTSD (n = 12) and women with abuse but without PTSD (n = 9) underwent positron emission tomographic measurement of cerebral blood flow during exposure to control, color Stroop, and emotional Stroop conditions. RESULTS:Women with abuse with PTSD (but not abused non-PTSD women) had a relative decrease in anterior cingulate blood flow during exposure to the emotional (but not color) classic Stroop task. During the color Stroop there were also relatively greater increases in blood flow in non-PTSD compared with PTSD women in right visual association cortex, cuneus, and right inferior parietal lobule. CONCLUSIONS:These findings add further evidence for dysfunction of a network of brain regions, including anterior cingulate and visual and parietal cortex, in abuse-related PTSD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Bremner JD,Vermetten E,Vythilingam M,Afzal N,Schmahl C,Elzinga B,Charney DSdoi
10.1016/j.biopsych.2003.10.001subject
Has Abstractpub_date
2004-03-15 00:00:00pages
612-20issue
6eissn
0006-3223issn
1873-2402pii
S0006322303010473journal_volume
55pub_type
杂志文章abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antidepressant...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.12.016
更新日期：2004-04-15 00:00:00
abstract：BACKGROUND:There is evidence that vascular factors contribute substantially to Alzheimer's disease (AD). We have developed assays to reliably detect the circulation and microcirculation regulating factors C-terminal endothelin-1 precursor fragment (CT-proET-1), midregional pro-adrenomedullin (MR-proADM), and midregiona...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.01.032
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is th...
journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2018-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00447-2
更新日期：1998-10-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90102-3
更新日期：1988-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1992-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.09.003
更新日期：2004-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.11.022
更新日期：2010-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.02.001
更新日期：2014-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90022-4
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pub_type： 临床试验,杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1983-02-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1996-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2005-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.05.023
更新日期：2008-10-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2016-08-15 00:00:00
abstract：:In crossover design with alternate assignment to order, 18 hyperkinetic children were treated with eyes-open rotational vestibular stimulation and with control contact, each eight times over 4-week periods. On behavioral ratings by teachers, they scored better after eight sessions of rotational stimulation than after ...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：BACKGROUND:The demands of the Wisconsin Card Sorting Test (WCST) change with experience. This report contains two studies designed to examine N-methyl-D-aspartate (NMDA) receptor contributions to the executive components of WCST performance. These aspects of WCST performance figure more prominently in the initial compl...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00097-9
更新日期：2000-01-15 00:00:00
abstract：BACKGROUND:Chronic stress is a major health concern, often leading to depression, anxiety, or when severe enough, posttraumatic stress disorder. While many studies demonstrate that the amygdala is hyperresponsive in patients with these disorders, the cellular neurophysiological effects of chronic stress on the systems ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.02.008
更新日期：2010-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-3223(97)00027-9
更新日期：1998-06-15 00:00:00
