Abstract:
BACKGROUND:The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuroleptic drug treatment as is suggested by animal research. METHODS:Prepulse inhibition was tested in five unmedicated and 20 medicated inpatients with schizophrenia, and 12 normal controls. RESULTS:The unmedicated schizophrenia patients showed a strong impairment of sensorimotor gating as indexed by the absence of prepulse inhibition. By contrast, the medicated patients showed a pronounced prepulse inhibition that did not differ from that of the normal controls. There was a substantial covariation between the rated severity of the positive syndrome and the amount of prepulse inhibition--i.e., the patients whose positive symptoms were rated as more severe showed less prepulse inhibition. CONCLUSIONS:These data suggest that the impaired sensorimotor gating of schizophrenia patients is not a stable vulnerability indicator, but may rather be related to the positive syndrome and may be improved by treatments with neuroleptic medication.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Weike AI,Bauer U,Hamm AOdoi
10.1016/s0006-3223(99)00229-2subject
Has Abstractpub_date
2000-01-01 00:00:00pages
61-70issue
1eissn
0006-3223issn
1873-2402pii
S0006-3223(99)00229-2journal_volume
47pub_type
杂志文章abstract::We studied 10 subjects each with melancholic depression evidencing significant motor retardation (RM), Parkinson's disease (PD) with bradykinesia, and normal healthy controls (NC), matched closely for age and gender, on measurements of motor function and depression, and their performance of simple and complex ballisti...
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更新日期:1994-02-15 00:00:00
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journal_title:Biological psychiatry
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更新日期:2016-02-15 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
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更新日期:2006-03-01 00:00:00
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更新日期:2015-05-15 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-15 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2007-03-15 00:00:00
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pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.07.024
更新日期:2007-08-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1998-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:1991-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(03)00525-0
更新日期:2003-11-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2011.10.032
更新日期:2012-04-15 00:00:00