Abstract:
BACKGROUND:The etiology of dementia that occurs in patients with schizophrenia is not well understood. Nicotinic acetylcholine receptors have been implicated in cognitive function, and deficits in these receptors have been reported in schizophrenia. METHODS:The present study investigates possible associations of nicotinic receptor subunit expression in the dorsal lateral prefrontal cortex, an area known to be affected in schizophrenia, and dementia rating. RESULTS:alpha7 immunoreactivity was reduced by 20% to 28% and [(3)H]epibatidine binding was increased twofold in groups of patients with schizophrenia compared to normal control subjects matched for age, postmortem delay, and low levels of brain nicotine and cotinine. In contrast, no significant differences in alpha4, alpha3, or beta2 immunoreactivity or alpha7 messenger RNA expression were observed in schizophrenia patients compared with control subject values. Clinical dementia ratings in patients with schizophrenia were correlated with neither [(3)H]epibatidine binding nor nicotinic receptor subunit expression. CONCLUSIONS:These data indicate no relationship between the trend for reduced neocortical alpha7 subunit protein expression in schizophrenia and dementia. Further investigations are required to establish whether the reduction in alpha7 protein in the dorsal lateral prefrontal cortex is associated with clinical features other than dementia in schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Martin-Ruiz CM,Haroutunian VH,Long P,Young AH,Davis KL,Perry EK,Court JAdoi
10.1016/s0006-3223(03)00348-2subject
Has Abstractpub_date
2003-12-01 00:00:00pages
1222-33issue
11eissn
0006-3223issn
1873-2402pii
S0006322303003482journal_volume
54pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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