Abstract：
BACKGROUND:Obsessive-compulsive disorder (OCD) is a psychiatric condition that typically manifests in compulsive urges to perform irrational or excessive avoidance behaviors. A recent account has suggested that compulsivity in OCD might arise from excessive stimulus-response habit formation, rendering behavior insensitive to goal value. We tested if OCD patients have a bias toward habits using a novel shock avoidance task. To explore how habits, as a putative model of compulsivity, might relate to obsessions and anxiety, we recorded measures of contingency knowledge, explicit fear, and physiological arousal. METHODS:Twenty-five OCD patients and 25 control subjects completed a shock avoidance task designed to induce habits through overtraining, which were identified using goal-devaluation. The relationship between habitual behavior, erroneous cognitions, and physiological arousal was assessed using behavior, questionnaires, subjective report, and skin conductance responses. RESULTS:A devaluation sensitivity test revealed that both groups could inhibit unnecessary behavioral responses before overtraining. Following overtraining, OCD patients showed greater avoidance habits than control subjects. Groups did not differ in conditioned arousal (skin conductance responses) at any stage. Additionally, groups did not differ in contingency knowledge or explicit ratings of shock expectancy following the habit test. Habit responses were associated with a subjective urge to respond. CONCLUSIONS:These data indicate that OCD patients have a tendency to develop excessive avoidance habits, providing support for a habit account of OCD. Future research is needed to fully characterize the causal role of physiological arousal and explicit fear in habit formation in OCD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Gillan CM,Morein-Zamir S,Urcelay GP,Sule A,Voon V,Apergis-Schoute AM,Fineberg NA,Sahakian BJ,Robbins TWdoi
10.1016/j.biopsych.2013.02.002subject
Has Abstractpub_date
2014-04-15 00:00:00pages
631-8issue
8eissn
0006-3223issn
1873-2402pii
S0006-3223(13)00145-5journal_volume
75pub_type
杂志文章abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...
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更新日期：1998-12-15 00:00:00
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更新日期：1978-12-01 00:00:00
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更新日期：2004-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-08-15 00:00:00
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更新日期：2018-02-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-06-15 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1997-09-01 00:00:00
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journal_title：Biological psychiatry
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更新日期：1995-03-01 00:00:00
