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Histochemical changes in the blood cells of schizophrenic patients under pimozide treatment.

Abstract：

:Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal distribution of nucleohistones. This pattern has been attributed to an increase of arginine-rich histones in schizophrenics. Pimozide administration exerted a normalizing effect on the nucleohistone distribution pattern. These findings further support our view that genomic expression abnormalities may be related to schizophrenic illness.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Stefanis CN,Issidorides MR

subject

Has Abstract

pub_date

1976-02-01 00:00:00

pages

53-68

issue

1

eissn

0006-3223

issn

1873-2402

journal_volume

11

pub_type

临床试验,杂志文章

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