Abstract:
BACKGROUND:Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknown, electrophysiological evidence has linked this region to error-processing abnormalities in patients with OCD. In this functional magnetic resonance imaging (fMRI) study, we sought to further localize error-processing differences within the ACC of OCD patients compared with healthy subjects. METHODS:Event-related fMRI data were collected for eight OCD patients and seven healthy subjects during the performance of a simple cognitive task designed to elicit errors but not OCD symptoms. RESULTS:Both OCD patients and healthy subjects demonstrated dorsal ACC activation during error commission. The OCD patients exhibited significantly greater error-related activation of the rostral ACC than comparison subjects. Activity in this region was positively correlated with symptom severity in the patients. CONCLUSIONS:Error-processing abnormalities within the rostral anterior cingulate occur in the absence of symptom expression in patients with OCD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Fitzgerald KD,Welsh RC,Gehring WJ,Abelson JL,Himle JA,Liberzon I,Taylor SFdoi
10.1016/j.biopsych.2004.10.038subject
Has Abstractpub_date
2005-02-01 00:00:00pages
287-94issue
3eissn
0006-3223issn
1873-2402pii
S0006-3223(04)01161-8journal_volume
57pub_type
杂志文章abstract:BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is th...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2018.05.011
更新日期:2018-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.biopsych.2005.04.030
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Anterior cingulate cortex has been implicated in the pathogenesis of major depressive disorder (MDD). With single voxel proton magnetic resonance spectroscopy, we reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in 14 pediatric MDD patients ver...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.05.007
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Recent findings suggest that both low and very high fasting blood glucose concentrations may be linked with depression, though whether type 2 diabetes is associated with depression may depend on awareness of the diagnosis. We explored the association between fasting glucose and type 2 diabetes (undiagnosed a...
journal_title:Biological psychiatry
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abstract::Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial and clinically heterogeneous disorder that is associated with tremendous financial burden, stress to families, and adverse academic and vocational outcomes. Attention-deficit/hyperactivity disorder is highly prevalent in children worldwide, and the pr...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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更新日期:1992-12-15 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
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更新日期:1975-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2007-04-01 00:00:00
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更新日期:2019-10-01 00:00:00
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更新日期:2018-07-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2006-06-01 00:00:00
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更新日期:1986-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-03-15 00:00:00
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pub_type: 杂志文章
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更新日期:1993-04-15 00:00:00
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pub_type: 杂志文章
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更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:There is increasing evidence for an association between alterations of brain glutamatergic neurotransmission and the pathophysiology of affective disorders. METHODS:We studied the association between cerebrospinal fluid (CSF) metabolites, including glutamine, in unipolar and bipolar depressed patients versu...
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pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Several studies have reported elevated S100B serum levels in schizophrenia. Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia. METHODS:S100B a...
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pub_type: 杂志文章
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更新日期:2009-06-15 00:00:00
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pub_type: 杂志文章
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更新日期:1993-12-15 00:00:00
abstract:BACKGROUND:There is evidence of abnormal cerebral dopamine transmission in nicotine-dependent smokers, but it is unclear whether dopaminergic abnormalities are due to acute nicotine abuse or whether they persist with abstinence. We addressed this question by conducting longitudinal positron emission tomography (PET) ex...
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pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00