Abstract:
BACKGROUND:There is growing evidence that the dysregulation of circadian rhythms may play an important role in irregular sleep-waking in demented elderly. In this study, we investigated daily variation of the pineal hormone melatonin, which has been reported to possess hypnogenic and synchronizing effects, in patients with senile dementia of Alzheimer's type. METHODS:Serum melatonin secretion rhythms in inpatients with senile dementia of Alzheimer's type (SDAT group, n = 10, average age = 75.7 years) with disturbed sleep-waking and nondemented elderly (ND group, n = 10, age = 78.3 years) without clinical sleep disorders in the same facility were monitored under a dim light condition without excessive physical exercise. RESULTS:The SDAT group showed a significantly higher degree of irregularities in actigraphically recorded rest-activity (R-A) rhythm during the 7-day baseline period compared with the ND group. The SDAT group simultaneously showed significantly reduced amplitude, larger variation of peak times, and diminished amount of total secretion in the melatonin secretion rhythm compared with the ND group. There were significantly positive correlations between the severity of R-A rhythm disorder and the reduced amplitude as well as diminished amount of total melatonin secretion. CONCLUSIONS:The SDAT patients with disturbed sleep-waking possessed melatonin secretion rhythm disorders that may play an important role in irregular sleep-waking in demented elderly.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Mishima K,Tozawa T,Satoh K,Matsumoto Y,Hishikawa Y,Okawa Mdoi
10.1016/s0006-3223(97)00510-6subject
Has Abstractpub_date
1999-02-15 00:00:00pages
417-21issue
4eissn
0006-3223issn
1873-2402pii
S0006322397005106journal_volume
45pub_type
杂志文章abstract:BACKGROUND:Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability, and predictors of mood and anxiety diso...
journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1984-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-09-10 00:00:00
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1990-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2008-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2014-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.06.009
更新日期:2012-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.01.013
更新日期:2019-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(89)90158-3
更新日期:1989-01-15 00:00:00