Abstract:
BACKGROUND:Functional brain imaging of young people at increased genetic risk for bipolar disorder provides a means of identifying potential endophenotypes for this condition. Dysfunctional neural mechanisms for the cognitive control of emotion are implicated in the genetic predisposition to bipolar disorder, with aberrant activity in frontocortical, striatal, and limbic brain regions previously reported in subjects with established bipolar disorder during inhibitory and emotion processing tasks. METHODS:Functional brain activity during inhibition of emotional material in young people at increased genetic risk for bipolar disorder was investigated using a facial-emotion go/no-go task during functional magnetic resonance imaging. Data from 47 genetically high-risk individuals aged 18 to 30 years with at least one first-degree relative with bipolar disorder were compared with 49 control subjects (within the same age range but without a family history of bipolar disorder or other severe mental illness). RESULTS:Whole-brain corrected analyses revealed a highly specific and significant lack of recruitment of the inferior frontal gyrus when inhibiting responses to fearful faces in the high-risk participants compared with control subjects (p = .011, family-wise error, peak voxel). CONCLUSIONS:Impaired inhibitory function of the inferior frontal cortex may represent a trait marker of vulnerability to bipolar disorder. That this finding was revealed during inhibition of emotional material further implicates dysregulated frontolimbic brain networks as a potential neurocognitive endophenotype for bipolar disorder and provides evidence for pre-existing functional disturbances in those at high genetic risk for bipolar disorder.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Roberts G,Green MJ,Breakspear M,McCormack C,Frankland A,Wright A,Levy F,Lenroot R,Chan HN,Mitchell PBdoi
10.1016/j.biopsych.2012.11.004subject
Has Abstractpub_date
2013-07-01 00:00:00pages
55-61issue
1eissn
0006-3223issn
1873-2402pii
S0006-3223(12)00983-3journal_volume
74pub_type
杂志文章abstract:BACKGROUND:Previous neuroimaging studies have demonstrated exaggerated amygdala responses to negative stimuli in posttraumatic stress disorder (PTSD). The time course of this amygdala response is largely unstudied and is relevant to questions of habituation and sensitization in PTSD exposure therapy. METHODS:We applie...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.12.026
更新日期:2005-03-01 00:00:00
abstract::There is a strong association between depression and smoking. Because monoamine oxidase (MAO) inhibition leads to antidepressant effect and in vitro studies have shown that cigarette smoke inhibits MAO activity, it is conceivable that smoking may have an antidepressant effect, if smokers have reduced MAO activity. The...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/0006-3223(95)00084-4
更新日期:1995-12-01 00:00:00
abstract::Determinations of albumin and immunoglobulin G (IgG) were performed in paired cerebrospinal fluid (CSF) and serum samples from 24 subjects with schizophrenia. These determinations allowed calculation of two indices, one that is an indicator of integrity of the blood-brain barrier and the other a measure of selective I...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(85)90002-2
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Cognitive behavioral therapy (CBT) has efficacy for binge eating disorder (BED) but not obesity. No controlled studies have tested whether adding obesity medication to CBT facilitates weight loss. We performed a randomized, placebo-controlled study of orlistat administered with guided self-help CBT (CBTgsh)....
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.biopsych.2005.03.001
更新日期:2005-05-15 00:00:00
abstract:BACKGROUND:Symptom provocation is used to study a wide variety of medical disorders. In contrast to other areas of medicine, the application of these procedures to the study of mental disease has generated significant scientific, political, and public debate. Purported differences include an overabundance of these proc...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(01)01221-5
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB. METHODS:The study used prospective longitudinal data from the European IMAGEN study ado...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.01.027
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Reduction of P300 amplitude in children and adolescents at high risk for developing alcoholism has frequently been reported. It has been hypothesized that this reduction represents a developmental delay in reaching age-appropriate levels in P300 amplitude. Using latent growth analysis of longitudinal data ob...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(99)00032-3
更新日期:1999-10-01 00:00:00
abstract::Dietary administration of L-tryptophan to rats failed to increase blood platelets. Instead platelet counts were decreased after feeding either a tryptophan-deficient or tryptophan-enriched (10%) diet, but were unchanged in animals on a 1% tryptophan diet. Platelet median volumes were not affected by any of these dieta...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Variations in maternal care in the rat associate with robust differences in hippocampal development and synaptic plasticity in the offspring. Maternal care also influences pituitary-adrenal stress responses and corticosterone (CORT) regulation of hippocampal plasticity. N-methyl-D-aspartate receptors (NMDAR)...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.03.016
更新日期:2012-09-15 00:00:00
abstract:BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(03)00295-6
更新日期:2003-09-15 00:00:00
abstract::Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(87)90184-3
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Pharmacological evidence support that enhancement of serotonin (5-HT) neurotransmission is critical for treatment efficacy in obsessive-compulsive disorder (OCD). Surprisingly, acute tryptophan depletion (ATD), a procedure known to reduce 5-HT neurotransmission, carried out in remitted OCD patients on select...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.biopsych.2005.08.023
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Brain imaging research in posttraumatic stress disorder has been largely performed on patients with chronic disease, often heavily medicated, with current or past alcohol and substance abuse. Additionally, virtually only activation brain imaging paradigms have been done in posttraumatic stress disorder, wher...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(03)00525-0
更新日期:2003-11-15 00:00:00
abstract:BACKGROUND:Intracellular deposition of tau protein is a hallmark lesion of Alzheimer's disease. Although it is known this event is secondary to excessive tau phosphorylation, the mechanisms involved remain unknown. We previously reported that the enzyme 5-Lipoxygenase (5LO) acts as a modulator of Aβ peptides formation ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.12.012
更新日期:2013-09-01 00:00:00
abstract::The effects of two putative attention-engaging maneuvers on tracking performance were studied in three groups of subjects: inpatients (n = 19), outpatients (n = 19), and controls (n = 20). One method involved realerting subjects during tracking by repeating instructions to track carefully. The second method, a signal ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::Although several reports agree that smooth-pursuit eye movement (SPEM) is abnormal in some obsessive-compulsive disordered (OCD) patients, differences between treatments and lack of accuracy in control selection make the results controversial. Although reduced gain seems the most accepted abnormality, the characterist...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/s0006-3223(95)00607-9
更新日期:1996-12-01 00:00:00
abstract::Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal dis...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Elevated endogenous levels of corticosteroids cause neural dysfunction and loss, especially within the hippocampus, as well as cognitive impairment in hippocampus-mediated tasks. Because Cushing's syndrome patients suffer from hypercortisolism, they represent a unique opportunity to study the impact of eleva...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.09.003
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Previous studies demonstrate that indirect activation of monoamine receptors by antidepressant treatment increases neurotrophic factors that activate the mitogen-activated protein kinase cascade; however, it is also possible that these monoamine receptors influence the mitogen-activated protein kinase pathwa...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(03)00346-9
更新日期:2003-11-15 00:00:00
abstract::We have investigated the dexamethasone suppression of cortisol release in a group of 28 patients with senile dementia of the Alzheimer type (SDAT) after stimulation by physostigmine and clonidine, as compared with basal conditions. All patients but one had previously been evaluated with a depression symptom checklist ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(88)90102-3
更新日期:1988-01-01 00:00:00
abstract::The present review explores the descriptive epidemiology of schizophrenia. Risk factors and correlates are divided into three groups based on whether the available evidence is consistent and strong, consistent and potentially strong, or inconsistent. The paper then considers epidemiologic studies of the course of illn...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(99)00153-5
更新日期:1999-10-01 00:00:00
abstract::The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90143-n
更新日期:1992-07-01 00:00:00
abstract::Over the past 30 years, investigators have used nonlinear and so-called chaos theory-based techniques to examine a wide range of phenomena ranging from electroencephalogram and cardiac rate and rhythm analyses to stock market and weather predictions. Psychiatric neuroscientists are now beginning to apply nonlinear met...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(02)01701-8
更新日期:2003-01-01 00:00:00
abstract::Previous studies suggest that catecholaminergic overactivity and structural brain damage may contribute to the pathogenesis of tardive dyskinesia (TD). Although dopaminergic (DA) mechanisms, specifically postsynaptic receptor supersensitivity, have been extensively studied, equally plausible noradrenergic (NE) changes...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(86)90245-3
更新日期:1986-07-01 00:00:00
abstract::Our results seem to indicate the existence of a locus in the major histocompatibity complex (MHC) region, correlated to schizophrenic illness and strictly linked to the loci HL-A and MLR. The associations found between these last loci and the disease can probably be explained by a linkage disequilibrium or a selective...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Recent studies have raised concerns about subtle long-lasting neurobiological changes that might be triggered by exposure to Cannabis derivatives, especially in a critical phase of brain maturation, such as puberty. The mesolimbic dopamine (DA) system, involved in the processing of drug-induced reward, is a ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.05.006
更新日期:2004-07-15 00:00:00
abstract::Performance on tasks tapping automatic and voluntary aspects of memory, attention, and motor speed was examined in 14 patients with major depressive disorder, before and after 3 weeks of treatment with clomipramine (150 mg/day), a potent serotonin and noradrenaline uptake blocker with anticholinergic side effects. Per...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90179-p
更新日期:1991-12-01 00:00:00
abstract::Previous neuroimaging research has contributed insights regarding the neural substrates of specific psychiatric disorders. The purpose of this study was to determine the shared mediating neuroanatomy of anxiety symptoms across three different anxiety disorders. Data were pooled from 23 right-handed adult outpatients m...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/S0006-3223(97)00145-5
更新日期:1997-09-15 00:00:00
abstract::The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:Accurate recognition of facial expressions is crucial for social functioning. In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals. METHODS:Using event-relat...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.10.028
更新日期:2005-02-01 00:00:00