The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation.

abstract：:Seventeen drug-free patients with Alzheimer's disease (AD) and 15 normal elderly controls, of which 13 age- and sex-matched pairs were included, participated in a study of red blood cell (RBC) and plasma choline. Mean values for RBC choline, plasma choline, and the ratio of RBC/plasma choline did not differ between th...

journal_title：Biological psychiatry

authors： Greenwald BS,Edasery J,Mohs RC,Shah N,Trigos GG,Davis KL

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Subjects with chronic fatigue syndrome (CFS) frequently report symptoms of subnormal body temperature and low-grade fever. We conducted a study to determine whether CFS subjects manifest any abnormality of core body temperature (CBT) that might help explain their fatigue. METHODS:Continuous 24-hour recordin...

journal_title：Biological psychiatry

authors： Hamilos DL,Nutter D,Gershtenson J,Redmond DP,Clementi JD,Schmaling KB,Make BJ,Jones JF

更新日期：1998-02-15 00:00:00

abstract：BACKGROUND:Functional brain imaging of young people at increased genetic risk for bipolar disorder provides a means of identifying potential endophenotypes for this condition. Dysfunctional neural mechanisms for the cognitive control of emotion are implicated in the genetic predisposition to bipolar disorder, with aber...

journal_title：Biological psychiatry

authors： Roberts G,Green MJ,Breakspear M,McCormack C,Frankland A,Wright A,Levy F,Lenroot R,Chan HN,Mitchell PB

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Ventral tegmental area (VTA) brain-derived neurotrophic factor (BDNF) contributes to time-dependent increases in cue-induced cocaine seeking after withdrawal (incubation of cocaine craving). Here, we studied the role of glial cell line-derived neurotrophic factor (GDNF) in incubation of cocaine craving becau...

journal_title：Biological psychiatry

authors： Lu L,Wang X,Wu P,Xu C,Zhao M,Morales M,Harvey BK,Hoffer BJ,Shaham Y

更新日期：2009-07-15 00:00:00

abstract：:Studies at the basic and clinical levels demonstrate that neuronal atrophy and cell death occur in response to stress and in the brains of depressed patients. Although the mechanisms have yet to be fully elucidated, progress has been made in characterizing the signal transduction cascades that control neuronal atrophy...

journal_title：Biological psychiatry

authors： Duman RS,Malberg J,Nakagawa S,D'Sa C

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:Anxiety disorders are common after traumatic brain injury (TBI). Data on the neural correlates of these conditions are lacking. This study examines the relationship between brain damage, particularly to the orbitofrontal cortex (OFC) and temporal lobe, and anxiety symptoms and disorders. METHODS:Ninety-five...

journal_title：Biological psychiatry

authors： Vasa RA,Grados M,Slomine B,Herskovits EH,Thompson RE,Salorio C,Christensen J,Wursta C,Riddle MA,Gerring JP

更新日期：2004-02-01 00:00:00

abstract：:Schizophrenia is a debilitating mental illness that affects approximately 1% of the world's population. Despite much research in its neurobiology to aid in developing new treatments, little progress has been made. One system that has not received adequate attention is the kappa opioid system and its potential role in ...

journal_title：Biological psychiatry

authors： Clark SD,Abi-Dargham A

更新日期：2019-10-01 00:00:00

abstract：:This study is designed to measure effects of serotonin 1A (5-HT1A) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. Rats were first exposed to 60 inescapable shocks (15-sec duration, 0.8 mA, every 1 min +/- 15 sec), and 48 hr later, they were subjected to daily 15-min...

journal_title：Biological psychiatry

authors： Giral P,Martin P,Soubrié P,Simon P

更新日期：1988-02-01 00:00:00

abstract：:Since bipolar disorder is inherently a longitudinal illness characterized by recurrence and cycling of mood episodes, neurobiological theories involving kindlinglike phenomena appear to possess a certain explanatory power. An approach to understanding kindlinglike phenomena at the molecular level has been made possibl...

journal_title：Biological psychiatry

authors： Ghaemi SN,Boiman EE,Goodwin FK

更新日期：1999-01-15 00:00:00

abstract：:We investigated the computerized electroencephalography (cEEG) in a group of 85 normal adolescents. The spatial frequency of the cEEG was analyzed using various multivariate statistical techniques. The factor analyses revealed three factors that accounted for most of the variability in the data and that could be inter...

journal_title：Biological psychiatry

authors： Volkow ND,Gomez-Mont F,Inamdar S,Lamella M,Prichep L,John R

更新日期：1987-02-01 00:00:00

abstract：:This study investigates whether response to total sleep deprivation in depressed patients may be predicted by the presence of diurnal variation of mood. Diurnal variation was measured with two different self-rating scales in 140 untreated depressed patients. Sleep deprivation responders manifest a higher percentage of...

journal_title：Biological psychiatry

authors： Haug HJ

更新日期：1992-02-01 00:00:00

abstract：:Accumulating evidence supports the view that deregulation of the immune system represents an important vulnerability factor for psychosis. In a subgroup of psychotic patients, the high comorbidity with autoimmune and chronic inflammatory conditions suggests a common underlying immune abnormality leading to both condit...

journal_title：Biological psychiatry

authors： Bergink V,Gibney SM,Drexhage HA

更新日期：2014-02-15 00:00:00

abstract：:Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some conditions are defined by the presence of impairments in social interaction or maintaining interpersonal relationships;...

journal_title：Biological psychiatry

authors： King-Casas B,Chiu PH

更新日期：2012-07-15 00:00:00

abstract：:Olfactory sensitivity to two odorants, isoamyl acetate and androsterone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of an...

journal_title：Biological psychiatry

authors： Gross-Isseroff R,Luca-Haimovici K,Sasson Y,Kindler S,Kotler M,Zohar J

更新日期：1994-05-15 00:00:00

abstract：:Pre-treatment and posttreatment dexamethasone suppression test (DST) results in physically healthy elderly major depressives without dementia demonstrated an association between treatment and DST normalization. Sixty percent of subjects were nonsuppressors at baseline compared to 17% after intensive treatment. DST res...

journal_title：Biological psychiatry

authors： Meyers BS,Alpert S,Gabriele M,Kakuma T,Kalayam B,Alexopoulos GS

更新日期：1993-07-01 00:00:00

abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...

journal_title：Biological psychiatry

authors： Falkai P,Bogerts B,Rozumek M

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Schizophrenic patients have high rates of cigarette smoking compared with the general population. We compared sustained-release (SR) bupropion with placebo for smoking cessation in patients with schizophrenic disorders. We also examined how antipsychotic class predicts smoking cessation outcomes with bupropi...

journal_title：Biological psychiatry

authors： George TP,Vessicchio JC,Termine A,Bregartner TA,Feingold A,Rounsaville BJ,Kosten TR

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Brainstem auditory evoked potentials (BAEP) reflect the activation of brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These electrophysiological correlates of neural processing are highly automatic and not influenced by cognitive factors or task demands; however, data f...

journal_title：Biological psychiatry

authors： Baas JM,Milstein J,Donlevy M,Grillon C

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Neurochemical and electrophysiological studies indicate that the locus coeruleus (LC)-norepinephrine system is activated by physiological and external stressors. This activation is mediated in part by corticotropin-releasing factor (CRF), the hypothalamic neurohormone that initiates the endocrine response to...

journal_title：Biological psychiatry

authors： Van Bockstaele EJ,Peoples J,Valentino RJ

更新日期：1999-11-15 00:00:00

abstract：:Twenty-eight psychiatric patients with computerized tomography (CT) findings of ventricular abnormality most likely to result from prenatal/perinatal lesions (VA group) were compared to 28 sex- and age-matched psychiatric patients with normal neuroradiological findings (NCT group). The neuroradiological rater was blin...

journal_title：Biological psychiatry

authors： Franzek E,Becker T,Hofmann E,Flöhl W,Stöber G,Beckmann H

更新日期：1996-12-15 00:00:00

abstract：:A group of 29 bipolar manic-depressives completed a 12-month double-blind cross-over trial of low-dose and high-dose lithium prophylaxis. Twelve patients relapsed, and significantly more of the relapses occurred during the low-dose 6-month phase of the trial. There was a trend for relapse to occur within 2 months of a...

journal_title：Biological psychiatry

authors： Waters B,Lapierre Y,Gagnon A,Cahudhry R,Tremblay A,Sarantidis D,Gray R

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:In a Swedish study, delinquent boys had high serum levels of triiodothyronine (T3). Furthermore, former delinquents, followed up after about 30 years, had T3 levels significantly related to repeated criminality. The aim of the present study was to shed further light on the relationship between the thyroid ho...

journal_title：Biological psychiatry

authors： Stålenheim EG,von Knorring L,Wide L

更新日期：1998-05-15 00:00:00

abstract：:The preattentive automatic processing of 63 alcoholics and 27 controls was evaluated with an auditory inattentive event-related oddball paradigm. We examined the mismatch negativity and the N2-P3 complex. Results showed significantly greater amplitude for N2, P3 and the N2-P3 complex for controls but no individual lea...

journal_title：Biological psychiatry

authors： Realmuto G,Begleiter H,Odencrantz J,Porjesz B

更新日期：1993-04-15 00:00:00

abstract：:The present study was designed to examine differences in the electrodermal activity of schizophrenics born in the season of excessive risk (January-April), and those born in the season of nonexcessive risk (May-December). Thirty-two male schizophrenics were presented with a series of orienting tones (1000 Hz, 80dB, 2 ...

journal_title：Biological psychiatry

authors： Ohlund LS,Ohman A,Alm T,Ost LG,Lindström LH

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Pediatric Bipolar Disorder (BD) has been associated with a number of neurocognitive deficits not dissimilar to ADHD. This study compared neuropsychological profiles of 4 groups of adolescents (14-17 years): 41 Normal Controls (NC), 30 ADHD, 12 BD and 12 combined (BD+ADHD). METHODS:Participants were identifi...

journal_title：Biological psychiatry

authors： Rucklidge JJ

更新日期：2006-11-01 00:00:00

abstract：:We examined the circadian rhythm of core body temperature (CBT) in 22 school refusal patients, ages between 12 and 18 years, who did not have any physical or psychiatric disorders, but had indefinite complaints, and were suspected to have a circadian rhythm disturbance. To obtain normal data for analysis, CBT in 9 hea...

journal_title：Biological psychiatry

authors： Tomoda A,Miike T,Yonamine K,Adachi K,Shiraishi S

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:The microtubule-associated protein tau accumulates in neurodegenerative diseases known as tauopathies, the most common being Alzheimer's disease. One way to treat these disorders may be to reduce abnormal tau levels through chaperone manipulation, thus subverting synaptic plasticity defects caused by tau's t...

journal_title：Biological psychiatry

authors： Abisambra J,Jinwal UK,Miyata Y,Rogers J,Blair L,Li X,Seguin SP,Wang L,Jin Y,Bacon J,Brady S,Cockman M,Guidi C,Zhang J,Koren J,Young ZT,Atkins CA,Zhang B,Lawson LY,Weeber EJ,Brodsky JL,Gestwicki JE,Dickey CA

更新日期：2013-09-01 00:00:00

abstract：:Since the isolation of morphine from the opium poppy over 200 years ago, the molecular basis of opioid action has remained the subject of intense inquiry. The identification of specific receptors responsible for opioid function and the discovery of many chemically diverse molecules with unique opioid-like efficacies h...

journal_title：Biological psychiatry

authors： Manglik A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with increased risk for age-related diseases and early mortality. An accelerated rate of biological aging could contribute to this increased risk. To investigate, we assessed leukocyte telomere length (LTL), an emerging marker of biological age, in men and w...

journal_title：Biological psychiatry

authors： O'Donovan A,Epel E,Lin J,Wolkowitz O,Cohen B,Maguen S,Metzler T,Lenoci M,Blackburn E,Neylan TC

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Working memory impairments are commonly found in attention-deficit/hyperactivity disorder (ADHD) and often improve with psychostimulant treatment. Little is known about how these medications affect the function of frontoparietal brain regions engaged for working memory. This study used functional magnetic re...

journal_title：Biological psychiatry

authors： Wong CG,Stevens MC

更新日期：2012-03-01 00:00:00