Decreased serum amyloid beta(1-42) autoantibody levels in Alzheimer's disease, determined by a newly developed immuno-precipitation assay with radiolabeled amyloid beta(1-42) peptide.

Abstract:

BACKGROUND:Autoantibodies against amyloid beta (A beta) peptide found in patients with Alzheimer's disease (AD) also occur naturally in the general population independently of the cognitive status. METHODS:We compared serum A beta(1-42) autoantibody levels (A beta(1-42)-AL) of 96 AD patients and 30 healthy elderly control subjects (HC), assessing their diagnostic value for AD with a newly developed immunoprecipitation assay with radiolabeled A beta(1-42) peptide. RESULTS:We found a highly significant decrease of A beta(1-42)-AL in AD patients (p = .001) independently of age, cognitive status, and apolipoprotein E epsilon4 carrier status. Amyloid beta(1-42) autoantibody levels were correlated with gender in AD, with a higher level occurring in women. When A beta(1-42) autoantibody sensitivity (specificity) was set >80%, specificity (sensitivity) was below 50% to correctly allocate patients and healthy control subjects. CONCLUSIONS:Our data indicate a potentially pathophysiologic decrease of serum A beta(1-42) antibodies in AD. Amyloid beta(1-42) antibodies in the serum alone, however, seem not to be useful as a diagnostic marker of AD.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Brettschneider S,Morgenthaler NG,Teipel SJ,Fischer-Schulz C,Bürger K,Dodel R,Du Y,Möller HJ,Bergmann A,Hampel H

doi

10.1016/j.biopsych.2004.12.008

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

813-6

issue

7

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(04)01312-5

journal_volume

57

pub_type

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