Abstract:
BACKGROUND:Neuropsychological studies in subjects with eating disorders (EDs) have reported conflicting findings, which might be accounted for by several confounding variables, including neuroendocrine changes. METHODS:General abilities, executive functions, attention, and noneffortful learning were assessed in 45 patients with EDs and 45 healthy comparison subjects (HCS). Plasma levels of 17beta-estradiol, cortisol, allopregnanolone, dehydroepiandrosterone and its sulfate metabolite (DHEA and DHEAS) were evaluated in a subsample of patients and HCS. The influence of clinical, demographic, and neuroendocrine variables on neurocognitive performance was explored. RESULTS:Patients were slower than HCS on noneffortful learning and more accurate on a spatial executive task. DHEA and DHEAS were increased and positively correlated with accuracy on the executive task, while cortisol positively correlated with speed of noneffortful learning. CONCLUSIONS:A subtle impairment of noneffortful learning is the only neuropsychological deficit in patients with EDs. Changes in neuroactive steroids influence neurocognitive performance.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Galderisi S,Mucci A,Monteleone P,Sorrentino D,Piegari G,Maj Mdoi
10.1016/s0006-3223(02)01668-2subject
Has Abstractpub_date
2003-05-15 00:00:00pages
921-7issue
10eissn
0006-3223issn
1873-2402pii
S0006322302016682journal_volume
53pub_type
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journal_title:Biological psychiatry
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更新日期:2010-01-01 00:00:00
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
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更新日期:2012-11-01 00:00:00
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journal_title:Biological psychiatry
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2013-02-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/j.biopsych.2004.11.023
更新日期:2005-02-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/0006-3223(89)90037-1
更新日期:1989-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.biopsych.2017.03.012
更新日期:2017-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析
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更新日期:2007-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.05.021
更新日期:2008-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.biopsych.2005.06.034
更新日期:2006-02-15 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.biopsych.2003.10.004
更新日期:2004-03-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.09.026
更新日期:2014-07-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.09.016
更新日期:2004-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2013.10.027
更新日期:2014-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2018.06.014
更新日期:2019-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(00)01127-6
更新日期:2001-05-01 00:00:00