Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.


BACKGROUND:Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness. METHODS:Cerebrospinal fluid (CSF) levels of the excitatory amino acids glutamate (Glu) and aspartate (Asp) and the N-methyl-D-aspartate (NMDA) receptor modulator, glycine (GLY) were measured by high performance liquid chromatography in 32 patients with refractory affective disorder (16 female/16 male, 12 bipolar I, 12 bipolar II, and 8 unipolar) and in 14 age-matched controls. RESULTS:There was a significant reduction in CSF glutamate and glycine in patients versus controls. A diagnosis by sex interaction was present for CSF glycine with lower levels in female patients compared to female controls. Levels of the excitatory amino acids were highly inter-correlated in patients, but not in controls. In patients studied after 6 weeks of lamotrigine, there was a trend for CSF glutamate levels to increase. CONCLUSIONS:These data suggest that in patients with refractory affective disorder, excitatory amino acids are dysregulated, as exemplified both by the decreased CSF glutamate and glycine and their high intercorrelation compared to controls. Further controlled study of glutamatergic dysregulation and its relationship to the pathophysiology of affective disorders and potential mechanism of action of mood stabilizers appears indicated.


Biol Psychiatry


Biological psychiatry


Frye MA,Tsai GE,Huggins T,Coyle JT,Post RM




Has Abstract


2007-01-15 00:00:00














  • Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder.

    abstract:BACKGROUND:The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment. METHODS:We compared regional (head and body/tail) HC volumes in 46 patients w...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: MacQueen GM,Yucel K,Taylor VH,Macdonald K,Joffe R

    更新日期:2008-11-15 00:00:00

  • Fluoxetine and neuroleptic malignant syndrome.

    abstract::The authors present a case report of neuroleptic malignant syndrome (NMS) in a patient commencing treatment with fluoxetine alone who had previously been treated with several antipsychotic and antidepressant combinations. On reviewing the literature on the pathogenesis of NMS, the authors hypothesize a facilitative ro...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Halman M,Goldbloom DS

    更新日期:1990-09-15 00:00:00

  • Urinary tryptamine excretion in chronic schizophrenics with low platelet MAO activity.

    abstract::Reduced platelet MAO activity has been previously reported as a biochemical marker for a subgroup of psychiatric patients, including some chronic schizophrenics. As tryptamine metabolism appears to be sensitive to alterations in MAO activity, urinary tryptamine excretion was measured in chronic schizophrenics with low...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Sullivan JL,Coffey CE,Basuk B,Cavenar JO,Maltbie AA,Zung WW

    更新日期:1980-02-01 00:00:00

  • Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

    abstract:BACKGROUND:Antenatal maternal cortisol levels associate with alterations in the amygdala, a structure associated with emotion regulation, in the offspring. However, because offspring brain and behavior are commonly assessed years after birth, the timing of such maternal influences is unclear. This study aimed to examin...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rifkin-Graboi A,Bai J,Chen H,Hameed WB,Sim LW,Tint MT,Leutscher-Broekman B,Chong YS,Gluckman PD,Fortier MV,Meaney MJ,Qiu A

    更新日期:2013-12-01 00:00:00

  • Impaired Communication Between the Motor and Somatosensory Homunculus Is Associated With Poor Manual Dexterity in Autism Spectrum Disorder.

    abstract:BACKGROUND:Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are likely involved in fine motor skill and specifically motor learning. However, the role of these conn...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Thompson A,Murphy D,Dell'Acqua F,Ecker C,McAlonan G,Howells H,Baron-Cohen S,Lai MC,Lombardo MV,MRC AIMS Consortium, and Marco Catani.

    更新日期:2017-02-01 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Tyrka AR,Price LH,Kao HT,Porton B,Marsella SA,Carpenter LL

    更新日期:2010-03-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Lonsdorf TB,Merz CJ,Fullana MA

    更新日期:2019-06-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Tomasiewicz HC,Jacobs MM,Wilkinson MB,Wilson SP,Nestler EJ,Hurd YL

    更新日期:2012-11-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Kiecolt-Glaser JK,Habash DL,Fagundes CP,Andridge R,Peng J,Malarkey WB,Belury MA

    更新日期:2015-04-01 00:00:00

  • Concurrent validation of schizotaxia: a pilot study.

    abstract:BACKGROUND:Many first-degree relatives of patients with schizophrenia show deficits in clinical, neuropsychological, neurobiological and social domains, in the absence of psychosis. We recently reformulated Meehl's concept of schizotaxia to conceptualize the liability to schizophrenia, and we proposed preliminary crite...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Stone WS,Faraone SV,Seidman LJ,Green AI,Wojcik JD,Tsuang MT

    更新日期:2001-09-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Barch DM,Sheline YI,Csernansky JG,Snyder AZ

    更新日期:2003-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Meziane H,Schaller F,Bauer S,Villard C,Matarazzo V,Riet F,Guillon G,Lafitte D,Desarmenien MG,Tauber M,Muscatelli F

    更新日期:2015-07-15 00:00:00

  • The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice.

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Qvist P,Christensen JH,Vardya I,Rajkumar AP,Mørk A,Paternoster V,Füchtbauer EM,Pallesen J,Fryland T,Dyrvig M,Hauberg ME,Lundsberg B,Fejgin K,Nyegaard M,Jensen K,Nyengaard JR,Mors O,Didriksen M,Børglum AD

    更新日期:2017-07-01 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Williamson DE,Dahl RE,Birmaher B,Goetz RR,Nelson B,Ryan ND

    更新日期:1995-06-15 00:00:00

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    abstract::Psychiatric disturbances affect as many as 90% of patients with Alzheimer's disease (AD) and are a major focus of treatment. Depression is one of the most frequent psychiatric complications of AD, affecting as many as 50% of patients. In this context, depression is a significant public health problem that has a series...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Lyketsos CG,Olin J

    更新日期:2002-08-01 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Gross-Isseroff R,Luca-Haimovici K,Sasson Y,Kindler S,Kotler M,Zohar J

    更新日期:1994-05-15 00:00:00

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    abstract:BACKGROUND:Neurobiologic abnormalities in the thalamus have been implicated in the pathophysiology of obsessive-compulsive disorder. We recently reported increased thalamic volume in treatment-naive pediatric obsessive-compulsive disorder patients versus case-matched healthy comparison subjects that decreased to levels...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rosenberg DR,Benazon NR,Gilbert A,Sullivan A,Moore GJ

    更新日期:2000-08-15 00:00:00

  • Age and neuropsychologic function in schizophrenia: a decline in executive abilities beyond that observed in healthy volunteers.

    abstract:BACKGROUND:Kraepelin originally conceptualized schizophrenia as a degenerative brain disorder. It remains unclear whether the illness is characterized by a static encephalopathy or a deterioration of brain function, or periods of each condition. Assessments of cognitive function, as measured by neuropsychologic assessm...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Fucetola R,Seidman LJ,Kremen WS,Faraone SV,Goldstein JM,Tsuang MT

    更新日期:2000-07-15 00:00:00

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    abstract::Sleep and 24-hr body core temperature were measured during a 2- to 3-week study interval in 15 endogenous depressives, 12 patients after remission, and 10 normal control subjects. The total sample was subdivided into one group of persons who displayed at least one sleep onset REM episode (SOREM; latency less than or e...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Schulz H,Lund R

    更新日期:1983-12-01 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Smeraldi E,Bellodi L,Cazzullo CL

    更新日期:1976-12-01 00:00:00

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    abstract:BACKGROUND:Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. METHODS:Twenty elderly patients meeting DSM-IV criteria for m...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


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    更新日期:2000-11-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


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    更新日期:2010-11-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Emslie GJ,Mayes TL

    更新日期:2001-06-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Quednow BB,Kühn KU,Mössner R,Schwab SG,Schuhmacher A,Maier W,Wagner M

    更新日期:2008-09-01 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Young EA,Breslau N

    更新日期:2004-08-01 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Steptoe A,Strike PC,Perkins-Porras L,McEwan JR,Whitehead DL

    更新日期:2006-10-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Lindström LH,Gefvert O,Hagberg G,Lundberg T,Bergström M,Hartvig P,Långström B

    更新日期:1999-09-01 00:00:00

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    abstract::Fifteen subjects dependent on both opioids and cocaine completed an ascending and tapering schedule of buprenorphine dosing, with maintenance for 21 days at each dose of buprenorphine (4, 8, 12, 16 mg sublingual daily) during both ascending and tapering phases. Higher doses of buprenorphine led to greater reductions i...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Schottenfeld RS,Pakes J,Ziedonis D,Kosten TR

    更新日期:1993-07-01 00:00:00

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    abstract::Previous neuroimaging research has contributed insights regarding the neural substrates of specific psychiatric disorders. The purpose of this study was to determine the shared mediating neuroanatomy of anxiety symptoms across three different anxiety disorders. Data were pooled from 23 right-handed adult outpatients m...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Rauch SL,Savage CR,Alpert NM,Fischman AJ,Jenike MA

    更新日期:1997-09-15 00:00:00

  • Ritanserin in the treatment of cocaine dependence.

    abstract::Sixty-five cocaine-dependent subjects were enrolled into a 10-week randomized, double-blind study to determine the safety and efficacy of the serotonin-2 receptor antagonist, ritanserin (10 mg/day), in reducing cocaine consumption and craving. All subjects also participated in a structured intensive outpatient psychos...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Johnson BA,Chen YR,Swann AC,Schmitz J,Lesser J,Ruiz P,Johnson P,Clyde C

    更新日期:1997-11-15 00:00:00