Abstract:
BACKGROUND:Stimulation of alpha(2)-adrenergic receptors (alpha(2)-ARs) in the prefrontal cortex (PFC) has a beneficial effect on working memory and attentional regulation in monkeys. alpha(2)-adrenergic agonists like clonidine and guanfacine have been used experimentally and clinically for the treatment of attention deficit and hyperactivity disorder (ADHD). However, it is unknown if alpha(2)-ARs in the PFC are involved in the neural mechanisms underlying regulation of locomotor activity. METHODS:The alpha(2)-adrenergic antagonist yohimbine was infused bilaterally and chronically into the dorsolateral PFC (dlPFC) in two monkeys, using mini-osmotic pumps. Spontaneous locomotor activity was measured continuously before, during and after drug administration, using an activity monitor. RESULTS:The monkeys exhibited a dramatic increase in motoric activity during infusion of yohimbine into the dlPFC. Similar treatment with saline was without effect. Thus, the locomotor hyperactivity was due to blockade of alpha(2)-ARs, not because of nonspecific factors such as cortical damage by drug administration. CONCLUSIONS:The present study suggests that alpha(2)-ARs in the dlPFC are involved in inhibitory control of locomotor activity.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Ma CL,Arnsten AF,Li BMdoi
10.1016/j.biopsych.2004.11.004subject
Has Abstractpub_date
2005-01-15 00:00:00pages
192-5issue
2eissn
0006-3223issn
1873-2402pii
S0006-3223(04)01122-9journal_volume
57pub_type
杂志文章abstract:BACKGROUND:Fatigue is highly prevalent and causes serious disruption in quality of life. Although the underlying biological mechanism is unknown, increases in inflammation have been implicated. This prospective study examined the association between C-reactive protein (CRP), a biomarker of systemic inflammation, and fa...
journal_title:Biological psychiatry
pub_type: 杂志文章,多中心研究
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更新日期:2009-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2007-02-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0006-3223(99)00004-9
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.08.020
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pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
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