Abstract:
:The urinary excretion of 3beta,16beta-dihydroxy-5-androsten-17-one (16beta-OH-DHEA) is increased in patients with low renin essential hypertension. This steroid and its isomer 3beta,17beta-dihydroxy-5-androsten-16-one (16-oxo-A) have also been reported to have mineralocorticoid activity in adrenalectomized rats. These findings have led to the postulate that excessive secretion of 16beta-OH-DHEA may be responsible for the production of low renin essential hypertension. In this study unilaterally nephrectomized salt loaded rats injected once a week with 30 mg of 11-desoxycorticosterone acetate per/kg of body weight for 2 month periods developed hypertension. Rats given similar amounts of 16beta-OH-DHEA or 16-oxo-A and rats given no steroids did not develop hypertension. We conclude that it is unlikely that 16beta-OH-DHEA and 16-oxo-A are direct causative factors in the production of low renin essential hypertension.
journal_name
Steroidsjournal_title
Steroidsauthors
Ogihara T,Ichihara K,Yamamoto T,Kumahara Y,Kircher HW,Nugent CAdoi
10.1016/0039-128x(77)90105-2subject
Has Abstractpub_date
1977-01-01 00:00:00pages
17-20issue
1eissn
0039-128Xissn
1878-5867pii
0039-128X(77)90105-2journal_volume
29pub_type
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