Abstract：
:Besides regulating water and electrolyte homeostasis, the mineralocorticoid receptor (MR) elicits pathophysiological effects in the renocardiovascular system. Although the MR's closest relative, the glucocorticoid receptor (GR), acts as a transcription factor at the same hormone-response-element (HRE), activated glucocorticoid receptor mediates very different effects. One explanation for this discrepancy is that the MR interacts with additional signaling pathways in the cytosol. In the literature, there are several indications for an interaction between aldosterone/MR and the cAMP/CREB signaling. Here we summarize the current knowledge of the cross-talk between the two signaling pathways, including some unpublished observations of our own that indicate that MR/CREB signaling is mediated by calcineurin and has potentially pathophysiological consequences.
journal_name
Steroidsjournal_title
Steroidsauthors
Grossmann C,Ruhs S,Seiferth A,Gekle Mdoi
10.1016/j.steroids.2009.10.006subject
Has Abstractpub_date
2010-08-01 00:00:00pages
539-43issue
8-9eissn
0039-128Xissn
1878-5867pii
S0039-128X(09)00236-0journal_volume
75pub_type
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