Synthesis of a human long-term oxymetholone metabolite.

abstract：:The preparation of 3-oxo-4-azasteroid from A-nor-3,5-secosteroid-3-oic acid is described in a solventless condition catalysed by Lewis acid under microwave irradiation. We utilized urea as an environmentally benign source for the generation of ammonia for the aza cyclization reaction. ...

journal_title：Steroids

authors： Borthakur M,Boruah RC

更新日期：2008-07-01 00:00:00

abstract：:To identify new pathways of estrogen action and novel estrogen receptor α (ERα) biomodulators, we performed high throughput screening and used follow on assays and bioinformatics to identify small molecule ERα inhibitors with a novel mode of action. These studies led to identification of rapid extranuclear activation ...

journal_title：Steroids

authors： Zheng X,Andruska N,Yu L,Mao C,Kim JE,Livezey M,Helferich WG,Shapiro DJ

更新日期：2016-10-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is a multifunctional steroid with a broad range of biological effects in humans and animals. DHEA can be converted to multiple oxygenated metabolites in the brain and peripheral tissues. The mechanisms by which DHEA exerts its effects are not well understood. However, evidence that the ef...

journal_title：Steroids

authors： El Kihel L

更新日期：2012-01-01 00:00:00

abstract：:In the present study the possible dual effects of adenosine as substrate and adenosine receptor agonist in rat granulosa cells, cumulus-oocyte complexes, luteal cells and ovarian membranes are discussed. Adenosine is an indispensable compound in cell energy metabolism, as precursor to cofactors, second messenger and n...

journal_title：Steroids

authors： Billig H,Rosberg S,Johanson C,Ahrén K

更新日期：1989-11-01 00:00:00

abstract：:Early work in the field established that the 5 alpha-reduced metabolite of progesterone 3 alpha-OH-5 alpha-pregnan-20-one (allopregnanolone or 3 alpha,5 alpha-THP) is a potent positive modulator of the GABA(A) receptor (GABAR), the receptor mediating the effects of the primary inhibitory transmitter in the brain. This...

journal_title：Steroids

authors： Smith SS

更新日期：2002-05-01 00:00:00

abstract：:This report details the synthesis of 1) 3,4,4'-trihydroxy-alpha, alpha'-diethyl-trans-stilbene; 2) 3,4-bis-(p-hydroxyphenyl)-trans-3-hexenol; 3) 3,4-bis-(p-hydroxyphenyl)-2,4-cis,cis-hexadienol; 4) 3,4-bis-(3'-methoxy-4'-hydrophenyl)-trans-3-hexene; 5) 3,4-bis-(3',4'-dimethoxyphenyl)-trans-3-hexene. These compounds ar...

journal_title：Steroids

authors： Hill KA,Peterson DM,Damodaran KM,Rao PN

更新日期：1981-03-01 00:00:00

abstract：:A radioimmunoassay for the quantitation of the sum of free, glucuronidated and urine is described. The method is reliable and accurate. Using this method, urinary excretion of 16 alpha-hydroxyestrone was determined in normal men, premenopausal women, and postmenopausal women. The values were compared to the urinary ex...

journal_title：Steroids

authors： Naganuma H,Hershcopf RJ,Michnovicz JJ,Miyairi S,Bradlow HL,Fishman J

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder due to mutation in the CYP21A2 gene. OBJECTIVE:To elucidate the genetic basis of 21-hydroxylase-deficient CAH in Hong Kong Chinese patients. PATIENTS AND METHODS:Mutational analysis of the CY...

journal_title：Steroids

authors： Chan AO,But WM,Ng KL,Wong LM,Lam YY,Tiu SC,Lee KF,Lee CY,Loung PY,Berry IR,Brown R,Charlton R,Cheng CW,Ho YC,Tse WY,Shek CC

更新日期：2011-09-01 00:00:00

abstract：:Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...

journal_title：Steroids

authors： Schneider C,Schöler HF,Schneider RJ

更新日期：2004-04-01 00:00:00

abstract：:Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6β,7β,15β,16β-dimethylene-3-oxo-14α-hydroxy-17α-pregn-4-ene-21,17-carbolactone (2), 6β,7β,15β,16β-dimethylene-3,11-dioxo-17α-pregn-4-ene-21,17-carbolactone (3), 6β,7β,15β,16β-d...

journal_title：Steroids

authors： Baydoun E,Atia-Tul-Wahab,Iqbal S,Smith C,Choudhary MI

更新日期：2017-10-01 00:00:00

abstract：:The synthesis of 13C-labeled steroid hormones is reviewed. Two general approaches are highlighted: partial synthesis in which part of the steroid nucleus is replaced with 13C-labeled synthons, and total synthesis. Examples from both approaches, leading to (3-(3)C)-, (4-(13)C)-, (3,4-(13)C2)-, and (1,2,3,4-(13)C4)- lab...

journal_title：Steroids

authors： Zomer G,Stavenuiter JF

更新日期：1990-10-01 00:00:00

abstract：:Data are presented on the urinary corticosteroid metabolic profile of the mouse strain 129/svJ. Through the use of GC/MS we have characterized, or tentatively identified corticosterone (Kendall's compound B) metabolites of both the 11beta-hydroxy and 11-carbonyl (compound A) series in urine. Full mass spectra of the m...

journal_title：Steroids

authors： Shackleton CH,Hughes BA,Lavery GG,Walker EA,Stewart PM

更新日期：2008-10-01 00:00:00

abstract：:Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grou...

journal_title：Steroids

authors： Hnilickova J,Kohout L,Capdevila E,Esteve A,Vilaplana M,Molist M,Brosa C,Swaczynova-Oklestkova J,Slavikova B

更新日期：2010-12-01 00:00:00

abstract：:A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-pregn-4-en-20-yno (2,3-d) isoxazol-17-ol], a compound which also blocks recombination of free progester...

journal_title：Steroids

authors： McGinley R,Casey JH

更新日期：1979-02-01 00:00:00

abstract：:The sterol mixture isolated from the marine alga Eutreptia viridis consists mainly of delta 5,7-dienes which account for 80% of the free sterols. Eighteen different sterols were detected, including a novel sterol with the rare delta 23-unsaturation, viz. 24-ethylcholesta-5,7,23Z-trien-3 beta-o1. ...

journal_title：Steroids

authors： Zielinski J,Kokke WC,Fenical W,Djerassi C

更新日期：1982-10-01 00:00:00

abstract：:In an attempt to synthesize compounds with selective estrogen-receptor binding, fluoro- and amino-clomiphene were totally synthesized from benzyl chloride, and their estrogenic/antiestrogenic activity as well as that of some of their chemical intermediates was evaluated. The triazene prepared from the amino-clomiphene...

journal_title：Steroids

authors： Gazit A,Livshitz T,Shani J

更新日期：1986-07-01 00:00:00

abstract：:During the periparturient period, dairy cows are subjected to physiological changes that may induce immunosuppression and an increased susceptibility of the animal to bacterial infections such as mastitis. The incidence of clinical environmental mastitis is high during the last period of gestation, at parturition and ...

journal_title：Steroids

authors： Winters KR,Meyer E,Van Merris VM,Van Den Broeck WL,Duchateau L,Burvenich C

更新日期：2003-05-01 00:00:00

abstract：:Synthesis, biochemical and biological testing of the first carborane derivatives of estrogens are described. Estrone 3-carboranylmethyl ether was synthesized in two steps from estrone. Reduction of estrone 3-carboranylmethyl ether with sodium borohydride provided estradiol-17 beta 3-carboranylmethyl ether. Enzyme kine...

journal_title：Steroids

authors： Sweet F

更新日期：1981-02-01 00:00:00

abstract：:By the conventional methods of gas liquid chromatography (GLC) as well as mass spectrometry, 3beta,7alpha-dihydroxychol-5-en-24-oic acid (delta5-acid), a key intermediate of chenodeoxycholic acid biogenesis and its metabolic by-product, 3alpha,7alpha-dihydroxychol-4-en-24-oic acid (delta4-acid) have not yet been ident...

journal_title：Steroids

authors： Ikeda M,Yamasaki K

更新日期：1978-07-01 00:00:00

abstract：:We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormo...

journal_title：Steroids

authors： Taylor MK,Kviatkovsky SA,Hernández LM,Sargent P,Segal S,Granger DA

更新日期：2016-06-01 00:00:00

abstract：:We have monitored the effect of ergosterol on electrical capacitance and electrical resistance of the phosphatidylcholine bilayer membranes using chronopotentiometry method. The chronopotentiometric characteristic of the bilayers depends on constant-current flow through the membranes. For low current values, no electr...

journal_title：Steroids

authors： Naumowicz M,Petelska AD,Figaszewski ZA

更新日期：2011-09-01 00:00:00

abstract：:Carbenoxolone potentiates the mineralocorticoid activity of endogenous glucocorticoid hormones by inhibiting the enzyme 11 beta-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone to inactive 11-oxo-derivatives. We addressed the question of whether glucocorticoid activity is also affected by carbe...

journal_title：Steroids

authors： Soro A,Panarelli M,Holloway CD,Fraser R,Kenyon CJ

更新日期：1997-04-01 00:00:00

abstract：:The aim of the study was to evaluate the relationship between phytosterols, oxyphytosterols, and other markers of cholesterol metabolism and concomitant coronary artery disease (CAD) in patients with severe aortic stenosis who were scheduled for elective aortic valve replacement. Markers of cholesterol metabolism (pla...

journal_title：Steroids

authors： Luister A,Schött HF,Husche C,Schäfers HJ,Böhm M,Plat J,Gräber S,Lütjohann D,Laufs U,Weingärtner O

更新日期：2015-07-01 00:00:00

abstract：:Initial excretion studies with orally administered [monoethyl-1-3H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL-14C] DES were performed with orally dosed C3H high (MTV+) and low (MTV-) titer MMTV female mice. Extraction and...

journal_title：Steroids

authors： Helton ED,Gough BJ,King JW Jr,Thenot JP,Horning EC

更新日期：1978-04-01 00:00:00

abstract：:In this study, we investigated the binding characteristics of [3H]Delta(5)-androstene-3beta,17beta-diol to rabbit vaginal cytosolic and nuclear extracts and in freshly excised intact tissue strips. [3H]delta(5)-Androstene-3beta,17beta-diol bound to a protein(s) in the vaginal nuclear extract with high affinity (K(d)=3...

journal_title：Steroids

authors： Traish AM,Huang YH,Min K,Kim NN,Munarriz R,Goldstein I

更新日期：2004-01-01 00:00:00

abstract：:The 21-hydroxy analogues of 11,19-oxidoprogesterone and 6,19-oxidoprogesterone have been synthesized from readily available materials. Hydroxylation at C-21 was effected with iodosobenzene (from phenyliodosodiacetate and methanolic potassium hydroxide) on a 20-ketopregnane. For the 11,19-oxido derivative, the hydroxyl...

journal_title：Steroids

authors： Veleiro AS,Nevado MV,Monteserín MC,Burton G

更新日期：1995-03-01 00:00:00

abstract：:A technique of incubation of testicular tissue in vitro with radiolabeled precursors was applied in the investigation of the steroid biosynthesis by testes of four young men after long-term, high-dose estrogen treatment. A positive correlation between plasma and testicular steroid levels, and in vitro capacity of the ...

journal_title：Steroids

authors： Rodriguez-Rigau LJ,Tcholakian RK,Smith KD,Steinberger E

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:Estrogen replacement therapy increases risk for ovarian epithelial cancer, a cancer of mainly older women, yet the response of older ovarian surface epithelium (OSE) to repeat estrogen exposure overtime has not been studied. We have previously reported significant reductions in estrogen receptor (ER) protein...

journal_title：Steroids

authors： Gulliver LS,Hurst PR

更新日期：2012-05-01 00:00:00

abstract：:Several derivatives of the arthropod moulting hormone have been synthesized which were coupled to AH Sepharose 4B yielding about 2 mumole ligand per g wet gel. As an indication of the suitability of the ligands for biological work the puff inducing capacity of their methyl esters was tested. The methyl ester of inokos...

journal_title：Steroids

authors： Spindler KD,Hamann A,Spindler-Barth M,Ihne A,Beckers C,Emmerich H

更新日期：1976-04-01 00:00:00

abstract：:Postmitochondrial supernatant (PMS) (1) has been prepared from the homogenate of rat seminal vesicles and the characteristics of the binding reaction of 5alpha-dihydrotestosterone (DHT) to the cytoplasmic androgen receptor have been studied using a charcoal adsorption procedure. At 0 degrees C apparent equilibrium of ...

journal_title：Steroids

authors： Zakár T,Tóth M

更新日期：1977-12-01 00:00:00