Synthesis of 21-hydroxy-11,19-oxidopregn-4-ene-3,20-dione and 21-hydroxy-6,19-oxidopregn-4-ene-3,20-dione.

abstract：:Spermatozoa from bovine ejaculates and cauda epiditymidis were incubated with either tritiated 17 beta-hydroxy-5 alpha-androstane-3-one (DHT) or 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). Examination of the medium incubations demonstrated metabolic conversion of both DHT and 3 alpha-diol when these steri...

journal_title：Steroids

authors： Djöseland O,Høglo S,Nyberg K,Hastings CD,Attramadal A

更新日期：1978-03-01 00:00:00

abstract：:The urinary excretion of 3beta,16beta-dihydroxy-5-androsten-17-one (16beta-OH-DHEA) is increased in patients with low renin essential hypertension. This steroid and its isomer 3beta,17beta-dihydroxy-5-androsten-16-one (16-oxo-A) have also been reported to have mineralocorticoid activity in adrenalectomized rats. These...

journal_title：Steroids

authors： Ogihara T,Ichihara K,Yamamoto T,Kumahara Y,Kircher HW,Nugent CA

更新日期：1977-01-01 00:00:00

abstract：:Adrenal function and aging have been the object of intense interest in recent years. In this study we analyzed morning (08:00 h) serum cortisol concentrations from a sample of Chinese subjects aged from 31 to 110 years. These levels differed according to age, health status and sex, although the sex difference was conf...

journal_title：Steroids

authors： Zhao ZY,Lu FH,Xie Y,Fu YR,Bogdan A,Touitou Y

更新日期：2003-08-01 00:00:00

abstract：:The leaky heme mutants G204, G216, and G214 are shown to accumulate exogenous sterols. Unlike hem mutants which have complete blocks in the heme pathway, these strains do not require ergosterol, methionine, or unsaturated fatty acids for growth. The addition of aminolevulinic acid to the growth medium inhibited sterol...

journal_title：Steroids

authors： Shinabarger DL,Keesler GA,Parks LW

更新日期：1989-03-01 00:00:00

abstract：:A simplified, non-chromatographic method for aldosterone-gamma-lactone (2) radio-immunoassay is described, using a high titer aldosterone-gamma-lactone antibody. This method takes six working hours for completion; the blanks are below the sensitivity of the assay (0-10 pg), and the intra and interassay coefficient of ...

journal_title：Steroids

authors： Antunes JR,Dale SL,Melby JC

更新日期：1976-11-01 00:00:00

abstract：:The bile flow and the bile acid secretion, calculated on liver weight basis, increased 12 H and 24 H after 60-70% hepatectomy and returned to the initial levels thereafter. The biliary phospholipid secretion much more increased than bile acids, but the cholesterol secretion decreased. Bile acid composition changed wit...

journal_title：Steroids

authors： Fukano S,Saitoh Y,Uchida K,Akiyoshi T,Takeda K

更新日期：1985-03-01 00:00:00

abstract：:In this study, effects of estradiol, progesterone and genistein on uterine aquaporin (AQP)-1, 2, 5 and 7 expression were investigated in sex-steroid deficient state which could help to elucidate the mechanisms underlying uterine fluid volume changes that were reported under these hormone and hormone-like compound infl...

journal_title：Steroids

authors： Chinigarzadeh A,Muniandy S,Salleh N

更新日期：2016-11-01 00:00:00

abstract：:Three BS-BODIPY (brassinosteroids-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) conjugates were synthesized and their fluorescent and immunological properties were investigated. Two of the conjugates, having present all the functional groups characteristic of BS, were shown to be potentially useful as biological probes ...

journal_title：Steroids

authors： Malachowska-Ugarte M,Sperduto C,Ermolovich YV,Sauchuk AL,Jurášek M,Litvinovskaya RP,Straltsova D,Smolich I,Zhabinskii VN,Drašar P,Demidchik V,Khripach VA

更新日期：2015-10-01 00:00:00

abstract：:Within the adult female, estrogen signaling is well-described as an integral component of the physiologically significant hypothalamic-pituitary-gonadal axis. In rodents, the timing of ovulation is intrinsically entwined with the display of sexual receptivity. For decades, the importance of estradiol activating intrac...

journal_title：Steroids

authors： Tonn Eisinger KR,Larson EB,Boulware MI,Thomas MJ,Mermelstein PG

更新日期：2018-05-01 00:00:00

abstract：:Brassinosteroids (BRs) control several important agronomic traits, such as strengthening resistance to diverse adversity, improving the quality, and increasing crop yield. Their chemical structures and varieties, specific methods for the evaluation of bioactivities, structure-activity relationships, potential novel co...

journal_title：Steroids

authors： Liu J,Zhang D,Sun X,Ding T,Lei B,Zhang C

更新日期：2017-08-01 00:00:00

abstract：:The giant freshwater prawn, Macrobrachium rosenbergii, is important to many Asian countries due to its high economic value as an aquaculture product. With demand increasing, there is requirement for a better understanding of the biosynthetic components that regulate its growth and reproduction, including steroids, in ...

journal_title：Steroids

authors： Thongbuakaew T,Siangcham T,Suwansa-ard S,Elizur A,Cummins SF,Sobhon P,Sretarugsa P

更新日期：2016-03-01 00:00:00

abstract：:While the neuroprotective benefits of estrogen and progesterone in critical illness are well established, the data regarding the effects of androgens are conflicting. Surgical repair of congenital heart disease is associated with significant morbidity and mortality, but there are scant data regarding the postoperative...

journal_title：Steroids

authors： Heckmann M,d'Uscio CH,de Laffolie J,Neuhaeuser C,Bödeker RH,Thul J,Schranz D,Frey BM

更新日期：2014-03-01 00:00:00

abstract：:Orally administered testosterone undecanoate (TU), an anabolic, androgenic steroid, can potentially be abused by athletes. Indirect evidence for detecting oral TU intake could be deduced from the changes in steroid profile post-administration. Direct evidence could be obtained by detection of unchanged TU in plasma. T...

journal_title：Steroids

authors： Peng SH,Segura J,Farré M,González JC,de la Torre X

更新日期：2002-01-01 00:00:00

abstract：:Urinary steroid profile analysis requires enzymatic hydrolysis of glucuronide and sulfate conjugates and this is achieved simultaneously using Helix pomatia juice (HPJ), but steroids with 3beta-hydroxy-5-ene structure undergo transformation and yield of 5alpha-reduced corticosteroid glucuronides is poor. We describe t...

journal_title：Steroids

authors： Christakoudi S,Cowan DA,Taylor NF

更新日期：2008-03-01 00:00:00

abstract：:A series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker were synthesized, and characterized by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR, HRMS and HPLC. The synthesized compounds 6a-p were screened for their in vitro anticancer property against a panel of three can...

journal_title：Steroids

authors： Agarwal DS,Siva Krishna V,Sriram D,Yogeeswari P,Sakhuja R

更新日期：2018-11-01 00:00:00

abstract：:Carbenoxolone potentiates the mineralocorticoid activity of endogenous glucocorticoid hormones by inhibiting the enzyme 11 beta-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone to inactive 11-oxo-derivatives. We addressed the question of whether glucocorticoid activity is also affected by carbe...

journal_title：Steroids

authors： Soro A,Panarelli M,Holloway CD,Fraser R,Kenyon CJ

更新日期：1997-04-01 00:00:00

abstract：:Circulation levels of estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHAS) have been measured in plasma using a radioimmunoassay for estrone and dehydroepiandrosterone following extraction and hydrolysis of the sulfate. The mean +/- SE concentrations of E1S and DHAS in normal men were 458 +/- 25 pg/ml and 1...

journal_title：Steroids

authors： Franz C,Watson D,Longcope C

更新日期：1979-11-01 00:00:00

abstract：:Incubation of aldosterone with confluent layers of A6 (toad kidney) cells leads to its hydroxylation at the 6 beta-position. 6 beta-Hydroxyaldosterone is the major metabolite when the incubation is carried out at pH 6.8, whereas the product comprises 6 beta-hydroxy-17-isoaldosterone accompanied by some 6 beta-hydroxya...

journal_title：Steroids

authors： Morris DJ,Latif SA,Conca TJ,Wei LT,Watlington CO,Kirk DN,Toms HC,Shackleton CH

更新日期：1990-11-01 00:00:00

abstract：:An efficient procedure for the chemical synthesis of 3 beta-hydroxy-5 alpha-cholest-8-en-7-one and 3 beta-hydroxy-5 alpha-cholest-8-en-11-one is described. These ketosterols have been shown to have possible significant hypocholesterolemic effects when fed to normal rats at a level of 0.15% in a laboratory chow diet. T...

journal_title：Steroids

authors： Parish EJ,Nanduri VB,Seikel JM,Kohl HH,Nusbaum KE

更新日期：1986-11-01 00:00:00

abstract：:At the development of receptivity the endometrium undergoes specific changes. Several factors have been suggested as markers of endometrial receptivity. A common feature for most of these factors is that they are directly, or indirectly, regulated by progesterone. The effect of various doses and regimens of mifepristo...

journal_title：Steroids

authors： Danielsson KG,Marions L,Bygdeman M

更新日期：2003-11-01 00:00:00

abstract：:7-Oxo-dehydroepiandrosterone, which can be formed from dehydroepiandrosterone (DHEA) by several mammalian tissues, is more effective than its parent steroid as an inducer of thermogenic enzymes when administered to rats. Using the Morris water maze procedure, we tested DHEA and its 7-oxo-derivative for their ability t...

journal_title：Steroids

authors： Shi J,Schulze S,Lardy HA

更新日期：2000-03-01 00:00:00

abstract：:A short and efficient synthesis of steroid synthons, di(tert-butyldimethylsilyl) ethers of 3,21-dihydroxy-24-nor-chol-5-en-23-al (8 and 10) and of ethyl 3,21-dihydroxy-25-homo-chola-5,23-dien-25-oate (9 and 11), having natural (20R) and unnatural (20S) configuration from 3β-(tert-butyldimethylsilyloxy)-14α,20ξ-card-5-...

journal_title：Steroids

authors： Koenig H,Skiera I,Błaszczyk K,Paryzek Z

更新日期：2011-04-01 00:00:00

abstract：:Radioimmunoassay (RIA) for testosterone (T) in unchromatographed plasma extracts from ATD-treated rats gave spuriously high values for T. Cross-reaction and chromatographic studies subsequently showed that ATD and, to a much greater extent, its metabolite(s) were responsible for this overestimation. Celite column chro...

journal_title：Steroids

authors： Donaldson MD,Forest MG

更新日期：1980-12-01 00:00:00

abstract：:Synthesis, biochemical and biological testing of the first carborane derivatives of estrogens are described. Estrone 3-carboranylmethyl ether was synthesized in two steps from estrone. Reduction of estrone 3-carboranylmethyl ether with sodium borohydride provided estradiol-17 beta 3-carboranylmethyl ether. Enzyme kine...

journal_title：Steroids

authors： Sweet F

更新日期：1981-02-01 00:00:00

abstract：:Chronic kidney disease results in a reduction in 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and an accumulation of phosphorus in the blood, leading to secondary hyperparathyroidism and renal osteodystrophy. Vitamin D analogs that retain the ability to suppress PTH but that are less calcemic and phosphatemic than...

journal_title：Steroids

authors： Williams KB,DeLuca HF

更新日期：2008-11-01 00:00:00

abstract：:The concentration of estrogens in the body fluids of women is highly variable, due to the menstrual cycle, circadian oscillations, and other physiological and pathological causes. To date, only the cyclic fluctuations of the principal estrogens (estradiol and estrone) have been studied, with limited outcome of general...

journal_title：Steroids

authors： Bozzolino C,Vaglio S,Amante E,Alladio E,Gerace E,Salomone A,Vincenti M

更新日期：2019-10-01 00:00:00

abstract：:A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-pregn-4-en-20-yno (2,3-d) isoxazol-17-ol], a compound which also blocks recombination of free progester...

journal_title：Steroids

authors： McGinley R,Casey JH

更新日期：1979-02-01 00:00:00

abstract：:Glucocorticoids are important regulators of metabolism and immune function. Synthetic glucocorticoids are extensively used for immunosuppression/anti-inflammatory therapy. Since the glucocorticoid receptor (GR) is central to most hormone effects; its in vivo regulation will influence hormone/drug action. An alternativ...

journal_title：Steroids

authors： DuBois DC,Sukumaran S,Jusko WJ,Almon RR

更新日期：2013-02-01 00:00:00

abstract：:The aim of the study was to evaluate the relationship between phytosterols, oxyphytosterols, and other markers of cholesterol metabolism and concomitant coronary artery disease (CAD) in patients with severe aortic stenosis who were scheduled for elective aortic valve replacement. Markers of cholesterol metabolism (pla...

journal_title：Steroids

authors： Luister A,Schött HF,Husche C,Schäfers HJ,Böhm M,Plat J,Gräber S,Lütjohann D,Laufs U,Weingärtner O

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of physiologic levels of androgens and their precursors in the regulation of body composition, energy and substrate metabolism and aerobic capacity in healthy, cycling, premenopausal women. EXPERIMENTAL:We evaluated 30 young (27±1 year) premenopausal, non-obese (23±0.5 kg/m(2)), normally...

journal_title：Steroids

authors： Keller JL,Casson PR,Toth MJ

更新日期：2011-11-01 00:00:00