Chronopotentiometric studies of phosphatidylcholine bilayers modified by ergosterol.

abstract：:Using 1 alpha,2 alpha-oxido-cholesta-5,7-diene-3 beta,25-diol (2) as a starting material, the provitamins of calcitriol with an additional 2 beta-chloro-, 2 beta-fluoro-, and 2 beta-methoxy-substituent (3,4,5) are obtained by transdiaxial opening of the oxirane ring with nucleophiles. An efficient irradiation process ...

journal_title：Steroids

authors： Scheddin D,Mayer H,Schönecker B,Gliesing S,Reichenbächer M

更新日期：1998-12-01 00:00:00

abstract：:The use of steroid hormones as growth promoters remains illegal in Europe. A classical approach used to control their utilization consists to measure the parent drug in target biological matrices. However, this strategy may fail when the parent drug is submitted to extensive metabolism reactions. For urine and tissue ...

journal_title：Steroids

authors： Antignac JP,Brosseaud A,Gaudin-Hirret I,André F,Bizec BL

更新日期：2005-03-01 00:00:00

abstract：:The use of the synthetic progestin medroxyprogesterone acetate (MPA) for estrus prevention in the dog can result in overproduction of growth hormone, suppression of plasma glucocorticoid levels, and the induction of mammary tumors. Proligestone (PROL) was claimed to be devoid of these unwanted side effects. In the pre...

journal_title：Steroids

authors： Selman PJ,Wolfswinkel J,Mol JA

更新日期：1996-03-01 00:00:00

abstract：:Early work in the field established that the 5 alpha-reduced metabolite of progesterone 3 alpha-OH-5 alpha-pregnan-20-one (allopregnanolone or 3 alpha,5 alpha-THP) is a potent positive modulator of the GABA(A) receptor (GABAR), the receptor mediating the effects of the primary inhibitory transmitter in the brain. This...

journal_title：Steroids

authors： Smith SS

更新日期：2002-05-01 00:00:00

abstract：:In this study, we investigated the binding characteristics of [3H]Delta(5)-androstene-3beta,17beta-diol to rabbit vaginal cytosolic and nuclear extracts and in freshly excised intact tissue strips. [3H]delta(5)-Androstene-3beta,17beta-diol bound to a protein(s) in the vaginal nuclear extract with high affinity (K(d)=3...

journal_title：Steroids

authors： Traish AM,Huang YH,Min K,Kim NN,Munarriz R,Goldstein I

更新日期：2004-01-01 00:00:00

abstract：:17-Hydroxyprogesterone is a well-known precursor of androstenedione in adrenal biosynthesis. This study using sheep adrenal incubations demonstrates that 11-deoxycortisol, the precursor of cortisol synthesis, also can be a precursor of androstenedione. Indeed, our data show that androstenedione synthesis is negatively...

journal_title：Steroids

authors： Auzéby A,Bogdan A,Touitou Y

更新日期：1991-01-01 00:00:00

abstract：:The influence of daily injections, for 7 days, of 17-hydroxyprogesterone caproate (8 mg/100 g body weight pro die), of estradiol-17 beta 17-undecylate (1.2 mg/100 g body weight pro die) of testosterone enanthate (2 mg/100 g body weight pro die) and of ACTH (4 IU/100 g body weight pro die) to male Wistar rats, weighing...

journal_title：Steroids

authors： Bukhari AR,Guessab A,Nicol ML

更新日期：1981-07-01 00:00:00

abstract：:It has been previously demonstrated that 1,25 dihydroxyvitamin D(3) (1,25-D(3)) exerts inhibitory effects in breast cancer cells. The aim of this study was to determine whether mitogen-activated protein kinase (MAPK) pathways are associated with 1,25-D(3)-induced cell death in breast cancer. We used three breast cell ...

journal_title：Steroids

authors： Brosseau CM,Pirianov G,Colston KW

更新日期：2010-12-12 00:00:00

abstract：BACKGROUND AND AIMS:Calcitriol, an active vitamin D metabolite, has a limited application in bone repair because of its undesirable hypercalcaemic action. However it has emerged that lithocholic acid (LCA) is a non-calcaemic vitamin D receptor ligand but whether this steroid can support osteoblast maturation has not be...

journal_title：Steroids

authors： Mansell JP,Shorez D,Farrar D,Nowghani M

更新日期：2009-11-01 00:00:00

abstract：:This article has been withdrawn at the request of the Publisher and the Editor-in-Chiefs. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Steroids

authors： Prasad PV,Shrivastav TG,Sitruk-Ware R,Kumar N

更新日期：2010-11-12 00:00:00

abstract：BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...

journal_title：Steroids

authors： de Oliveira C,Iwanaga-Carvalho C,Mota JF,Oyama LM,Ribeiro EB,Oller do Nascimento CM

更新日期：2011-11-01 00:00:00

abstract：:Biotransformation of a synthetic progestonic hormone dydrogesterone (1), C21H28O2, with a plant pathogenic fungus Macrophomina phaseolina yielded two new 2 and 3, and a known 4 metabolites. These analogues were identified as, 3β,11α-dihydroxy-5β,9β,10α-pregna-7-ene-6,20-dione (2), 15β-hydroxy-9β,10α-pregna-4,6-diene-3...

journal_title：Steroids

authors： Wajid A,Ahmad MS,Yousuf S,Atia-Tul-Wahab,Jabeen A,Atta-Ur-Rahman,Choudhary MI

更新日期：2019-03-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone, respectively, is an important pre-receptor signaling pathway for the renal mineralocorticoid receptor (MR). This receptor has an equal affinity for the glucocorti...

journal_title：Steroids

authors： Stewart PM,Mason JI

更新日期：1995-01-01 00:00:00

abstract：:The high concentrations of dehydroepiandrosterone sulfate and pregnenolone sulfate in the mammalian brain, despite the blood-brain barrier's impermeability to these compounds, and the apparent independence of these concentrations from those in plasma prompted us to investigate whether enzymatic sulfation of dehydroepi...

journal_title：Steroids

authors： Rajkowski KM,Robel P,Baulieu EE

更新日期：1997-05-01 00:00:00

abstract：:In each menstrual cycle only very few follicles in the mammalian ovary undergo maturation and ovulation while most of the follicles degenerate in the process of atresia. Moreover, in the absence of pregnancy, the newly formed corpora lutea will degenerate and disappear in the process of luteolysis. Recent studies sugg...

journal_title：Steroids

authors： Amsterdam A,Keren-Tal I,Aharoni D

更新日期：1996-04-01 00:00:00

abstract：:Brassinosteroids (BRs) are steroid hormones regulating various aspects of plant metabolism, including growth, development and stress responses. However, little is known about the mechanism of their impact on antioxidant systems and phospholipid turnover. Using tobacco plants overexpressing H+/Ca2+vacuolar Arabidopsis ...

journal_title：Steroids

authors： Kretynin SV,Kolesnikov YS,Derevyanchuk MV,Kalachova TA,Blume YB,Khripach VA,Kravets VS

更新日期：2019-07-08 00:00:00

abstract：:Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. However, the importance o...

journal_title：Steroids

authors： Thomas P,Alyea R,Pang Y,Peyton C,Dong J,Berg AH

更新日期：2010-08-01 00:00:00

abstract：:The characterization of new conjugated vitamin D metabolites in rat bile was performed using HPLC, liquid chromatography/tandem mass spectrometry combined derivatization, and GC-MS. After the administration of 24,25-dihydroxyvitamin D(3) to rats, 23, 25-dihydroxy-24-oxovitamin D(3) 23-glucuronide, 3-epi-24, 25-dihydro...

journal_title：Steroids

authors： Higashi T,Miura K,Kikuchi R,Shimada K,Hiyamizu H,Ooi H,Iwabuchi Y,Hatakeyama S,Kubodera N

更新日期：2000-05-01 00:00:00

abstract：:Testosterone (17 beta -hydroxy-4-androsten-3-one ; T) and dihydrotestosterone (17 beta -hydroxy-5 alpha -androstan-3-one ; DHT) concentrations were determined by radioimmunoassay in different fetal tissues taken from male guinea-pigs. Androgen concentrations were maximal in the components of the Wolffian duct (vas def...

journal_title：Steroids

authors： Rigaudière N

更新日期：1981-08-01 00:00:00

abstract：:The luteinizing hormone (LH) surge initiates a cascade of proteolytic events that control ovulation. One of the genes induced by LH is the progesterone receptor (PR). Because mice with a mutant PR gene (PRKO) fail to ovulate and are infertile, we have used them as a model in which to determine PR target genes that mig...

journal_title：Steroids

authors： Robker RL,Russell DL,Yoshioka S,Sharma SC,Lydon JP,O'Malley BW,Espey LL,Richards JS

更新日期：2000-10-01 00:00:00

abstract：:The apolar ecdysteroid present in the developing embryo of the blue crab, Callinectes sapidus Rathbun, is tentatively identified as ponasterone A (2 beta, 14 alpha, 20,22-pentahydroxy-5, beta-cholest-7-en-6-one) on the basis of chromatographic, immunological, and mass spectral evidence. The apolar ecdysteroid present ...

journal_title：Steroids

authors： McCarthy JF

更新日期：1979-12-01 00:00:00

abstract：:There are currently two main candidates for the membrane receptor for 1,25(OH)2D3: the 1,25D3-MARRS protein/ERp57; and the classical VDR. The 1,25D3-MARRS protein is essential for hormone-stimulated phosphate and calcium uptake in chick intestinal cells, whereas the VDR is not. The 1,25D3-MARRS protein also shows a hi...

journal_title：Steroids

authors： Nemere I

更新日期：2005-05-01 00:00:00

abstract：:A cytochrome P450-deficient mutant of the pathogenic fungus, Candida albicans, which accumulates exclusively 14 alpha-methylsterols in place of the normal end product sterol, ergosterol, was examined for alterations in membrane fluidity by electron paramagnetic resonance. The results using four nitroxyl spin labels in...

journal_title：Steroids

authors： Lees ND,Kleinhans FW,Broughton MC,Pennington DE,Ricker VA,Bard M

更新日期：1989-03-01 00:00:00

abstract：:The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the ster...

journal_title：Steroids

authors： Timsit YE,Negishi M

更新日期：2007-03-01 00:00:00

abstract：:Plasma concentrations of dehydroepiandrosterone (DHEA), 5-androstene-3beta,17beta-diol (AED), and 17beta-estradiol (E2) in dairy cows and heifers and AED binding to uterine cytosolic estrogen receptor (ER) were studied. Plasma samples were collected from the subcutaneous abdominal (SA) and jugular (J) veins of heifers...

journal_title：Steroids

authors： Gabai G,Marinelli L,Simontacchi C,Bono GG

更新日期：2004-02-01 00:00:00

abstract：:Based on histological criteria, Kingsley and Bogdanove (3) reported that the benzoate ester of 17beta-hydroxy-5alpha-androstan-3-one (5alpha-DHT), unlike testosterone propionate, is unable to induce vaginal mucification when given subcutaneously to rats. In contrats, Kennedy (4) found in estrogen-pretreated rats that ...

journal_title：Steroids

authors： Kennedy TG,Armstrong DT

更新日期：1976-03-01 00:00:00

abstract：:Two isoforms of the androgen receptor (AR-A and AR-B), differing by a lack of the first 187 amino acids in the NH2-terminal transactivation domain of AR-A, are expressed in connective tissue and bone. Transient transfections of normal human osteoblastic cells (HOB) and of genital skin fibroblasts defective in AR (GSF-...

journal_title：Steroids

authors： Liegibel UM,Sommer U,Boercsoek I,Hilscher U,Bierhaus A,Schweikert HU,Nawroth P,Kasperk C

更新日期：2003-12-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) increases the growth and osteolytic potential of prostate cancer cells, making it important to control PTHrP expression in these cells. We show that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its non-hypercalcemic analog, EB1089, decrease PTHrP mRNA and cellular protein leve...

journal_title：Steroids

authors： Sepulveda VA,Weigel NL,Falzon M

更新日期：2006-02-01 00:00:00

abstract：:Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. Al...

journal_title：Steroids

authors： Ekhato IV,Hurley T,Lovdahl M,Revitte TJ,Guo L,Huang Y,Clipper S,Colson C

更新日期：2002-03-01 00:00:00

abstract：:Progesterone, estrone, estradiol-17 beta and corticosterone were quantified simultaneously for the first time in female American kestrel (Falco sparverius) plasma. A mean level for each hormone was determined for the laying and non-laying periods of the summer (April-September), and for February. Means were comparable...

journal_title：Steroids

authors： Rehder NB,Lague PC,Bird DM

更新日期：1984-04-01 00:00:00