Ovulation: a multi-gene, multi-step process.

abstract：:To gain further insight into the mechanism for inactivation of aromatase by androst-5-ene-7,17-dione (1) and its 19-nor analog 4, 10 beta-oxygenated steroids 5 and 6, delta 1(10)-steroid 7, and 19-oxo-5 beta,6 beta-epoxy compound 8 were synthesized and tested for their ability to inhibit aromatase in human placental m...

journal_title：Steroids

authors： Numazawa M,Tachibana M

更新日期：1997-07-01 00:00:00

abstract：:The syntheses of 15beta-carboxyethylmercapto-5alpha-dihydrotestosterone, 15beta-carbosyethylmercapto-5alpha-androstane-3beta, 17beta-diol and 15beta-carboxyethylmercapto-5alpha-androstane-3alpha, 17beta-diol and the preparation of their bovine serum albumin (BSA) conjugates are described. These conjugates were employe...

journal_title：Steroids

authors： Rao PN,Khan AH,Moore PH Jr

更新日期：1977-02-01 00:00:00

abstract：:The kinetics of 11 beta-hydroxysteroid dehydrogenase (11HSD) catalyzing the interconversion of cortisol (F) and cortisone (E) were compared in vitro following incubation of homogenates of human (N = 7) and baboon (N = 2) placenta. In both species, enzyme activity catalyzing the conversion of F to E was associated with...

journal_title：Steroids

authors： Pepe GJ,Albrecht ED

更新日期：1984-09-01 00:00:00

abstract：:Different phytoestrogens were tested as inhibitors of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus (17beta-HSDcl), a member of the short-chain dehydrogenase/reductase superfamily. Phytoestrogens inhibited the oxidation of 100microM 17beta-hydroxyestra-4-en-3-one and the reduction of 100micr...

journal_title：Steroids

authors： Kristan K,Krajnc K,Konc J,Gobec S,Stojan J,Lanisnik Rizner T

更新日期：2005-08-01 00:00:00

abstract：:Due to their high profile biological activity, the steroids are among the most important secondary metabolites. A review of literature on the synthesis of pentacyclic steroids is presented. ...

journal_title：Steroids

authors： Ibrahim-Ouali M

更新日期：2008-09-01 00:00:00

abstract：:Explants prepared from the neocortex and the fetal zone of the human fetal adrenal (gestational age 13 to 18weeks) were maintained under conditions of organ culture for 7 to 9 days during which time they were exposed to hACTH and various related peptides. Corticotrophic activity was monitored by the daily release of d...

journal_title：Steroids

authors： Branchaud CT,Goodyer CG,Hall CS,Arato JS,Silman RE,Giroud CJ

更新日期：1978-04-01 00:00:00

abstract：:A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), col...

journal_title：Steroids

authors： Rega M,Jiménez C,Rodríguez J

更新日期：2007-10-01 00:00:00

abstract：:The effect of attachment of a dimethylaminoethoxy or a dimethylaminopropoxy group at the 11 beta-position of estradiol (E2) on its relative binding affinity (RBA) to estrogen receptor (ER) and intrinsic biologic activity is described. The binding of 11 beta-[2-(N,N-dimethylamino) ethoxy]estra-1,3,5(10)-triene-3,17 bet...

journal_title：Steroids

authors： Qian XD,Abul-Hajj YJ

更新日期：1990-05-01 00:00:00

abstract：:Estrogen is an important atheroprotective molecule that causes the rapid dilation of blood vessels by stimulating endothelial nitric oxide synthase (eNOS). There is also evidence that estrogen modulates airway epithelial NO production, thereby potentially affecting bronchial hyperresponsiveness. Studies in cultured en...

journal_title：Steroids

authors： Shaul PW

更新日期：1999-01-01 00:00:00

abstract：:Studies were carried out on the effect of oxygen tension on progesterone (P) accumulation in rat granulosa cell cultures. At 1-2% oxygen, basal, luteinizing hormone (LH)-stimulated, and follicle stimulating hormone (FSH)-stimulated P accumulations were 20, 18, and 11%, respectively, of P levels at 20% oxygen. Basal P ...

journal_title：Steroids

authors： Koos RD,Feiertag MA

更新日期：1989-11-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions in humans and rodents, but its effects on renal tissue have not yet been fully understood. The aim of this study is to assess the effect of DHEA treatment on diabetic rats, mainly in relation to renal function and...

journal_title：Steroids

authors： Jahn MP,Gomes LF,Jacob MH,da Rocha Janner D,Araújo AS,Belló-Klein A,Ribeiro MF,Kucharski LC

更新日期：2011-05-01 00:00:00

abstract：:The concentration of estrogens in the body fluids of women is highly variable, due to the menstrual cycle, circadian oscillations, and other physiological and pathological causes. To date, only the cyclic fluctuations of the principal estrogens (estradiol and estrone) have been studied, with limited outcome of general...

journal_title：Steroids

authors： Bozzolino C,Vaglio S,Amante E,Alladio E,Gerace E,Salomone A,Vincenti M

更新日期：2019-10-01 00:00:00

abstract：:The high concentrations of dehydroepiandrosterone sulfate and pregnenolone sulfate in the mammalian brain, despite the blood-brain barrier's impermeability to these compounds, and the apparent independence of these concentrations from those in plasma prompted us to investigate whether enzymatic sulfation of dehydroepi...

journal_title：Steroids

authors： Rajkowski KM,Robel P,Baulieu EE

更新日期：1997-05-01 00:00:00

abstract：:A short and efficient synthesis of steroid synthons, di(tert-butyldimethylsilyl) ethers of 3,21-dihydroxy-24-nor-chol-5-en-23-al (8 and 10) and of ethyl 3,21-dihydroxy-25-homo-chola-5,23-dien-25-oate (9 and 11), having natural (20R) and unnatural (20S) configuration from 3β-(tert-butyldimethylsilyloxy)-14α,20ξ-card-5-...

journal_title：Steroids

authors： Koenig H,Skiera I,Błaszczyk K,Paryzek Z

更新日期：2011-04-01 00:00:00

abstract：:Cortisol 21-amine (21-amino-11beta,17-dihydroxy-4-pregnene-3,20-dione) was prepared and an enzyme immunoassay for cortisol in serum was established using cortisol 21-amine conjugated with alkaline phosphatase. The minimal amount of cortisol detected was 1ng/tube and the measurable range was from 1 to 80 microgram/d1, ...

journal_title：Steroids

authors： Kobayashi Y,Ogihara T,Amitani K,Watanabe F,Kiguchi T,Ninomiya I,Kumahara Y

更新日期：1978-07-01 00:00:00

abstract：:This article has been withdrawn at the request of the Publisher and the Editor-in-Chiefs. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Steroids

authors： Prasad PV,Shrivastav TG,Sitruk-Ware R,Kumar N

更新日期：2010-11-12 00:00:00

abstract：:Labeled beta-muricholic acid was obtained from germfree rats given [24-14C]-chenodeoxycholic acid. It was crystallized with the same unlabeled bile acid extracted from germfree rat pooled biles. Five patients fitted with a T-tube after cholecystectomy were given orally 100 mg of the bile acid. Metabolites of beta-muri...

journal_title：Steroids

authors： Sacquet E,Parquet M,Riottot M,Raizman A,Nordlinger B,Infante R

更新日期：1985-05-01 00:00:00

abstract：:Steroid delta 4-5 alpha- and delta 4-5 beta-reductase activity was determined in 16 human mammary tumors and 8 DMBA-induced rat mammary tumors using a spectrophotometric assay. Steroid delta 4-5 alpha-reductase was present in all tumors investigated while delta 4-5 beta-reductase was detected in only 6 estrogen recept...

journal_title：Steroids

authors： Abul-Hajj YJ

更新日期：1979-01-01 00:00:00

abstract：:The non-genomic action of steroid hormones regulates a wide variety of cellular responses including regulation of ion transport, cell proliferation, migration, death and differentiation. In order to achieve such plethora of effects steroid hormones utilize nearly all known signal transduction pathways. One of the key ...

journal_title：Steroids

authors： Alzamora R,Harvey BJ

更新日期：2008-10-01 00:00:00

abstract：:The crystal and molecular structure of 3-methoxy-9(10 leads to 19)abeo-1,3,5(10)-estratrien-17-one has been determined by X-ray analysis in order to ascertain the configuration at C(9). The seven-membered B-ring has a chair conformation and this causes the molecule to bow towards the alpha-face rather than towards the...

journal_title：Steroids

authors： Weeks CM,Rohrer DC,Duax WL

更新日期：1976-02-01 00:00:00

abstract：:1 alpha, 25-Dihydroxyvitamin D3 (1 alpha, 25-(OH)2D3) has been shown to rapidly increase cytosolic calcium in freshly isolated and cultured rat hepatocytes. The rise in cytosolic calcium is dependent on phospholipase A2 (PLA2) activation and cell alkalinization through the Na+/H+ antiport system. To further characteri...

journal_title：Steroids

authors： Rockwell JC,Sorensen AM,Baran DT

更新日期：1993-10-01 00:00:00

abstract：:A direct competitive heterologous enzyme-linked immunosorbent assay (ELISA) was developed and validated to determine follicular fluid estradiol levels of different antral follicular sizes (small, medium, and large) obtained from the ovaries of heifers in the follicular phase of the estrous cycle. Polyclonal antiestrad...

journal_title：Steroids

authors： Silván G,Illera JC,Illera M

更新日期：1993-07-01 00:00:00

abstract：:Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetyl...

journal_title：Steroids

authors： Grainger WS,Parish EJ

更新日期：2015-09-01 00:00:00

abstract：:16alpha-hydroxydehydroepiandrosterone was for the first time detected in human seminal plasma by using a combination of extraction, solvent partition, HPLC separation and final quantification by GC-MS as pentafluorobenzyloxime trimethylsilyl ether derivative in SIM mode. Three effective mass fragments m/z 266, 356 and...

journal_title：Steroids

authors： Hert J,Hill M,Hampl R

更新日期：2004-10-01 00:00:00

abstract：:Sphenocentrum jollyanum seeds (MeOH extract and n butanol fraction) exhibited urease inhibitory activity (IC50 40.0 ± 0.92, 28.6 ± 0.41). The Ethyl acetate (EtOAc) fraction gave significant antacid activity with an increase in the baseline pH value of 1.2 to 1.61 ± 0.00 and 1.53 ± 0.00 at 50 and 100 mg, respectively, ...

journal_title：Steroids

authors： Akinwumi IA,Sonibare MA,Yeye EO,Khan M

更新日期：2020-07-01 00:00:00

abstract：:Human mammary medullary carcinoma cells (passages 16 to 21) were cultured for 2 days to allow for attachment, followed by 6 days of culture in either fetal calf serum, human cord blood, human amniotic fluid, or growth factors in the presence or absence of purified human alpha-fetoprotein (AFP). When growth factors wer...

journal_title：Steroids

authors： Leal JA,Gangrade BK,Kiser JL,May JV,Keel BA

更新日期：1991-05-01 00:00:00

abstract：:Carbon-13 nuclear magnetic resonance spectra for 31 3 beta-hydroxy and acetoxy androstane derivatives bearing vicinal oxygenated functions at ring D with and without oxygenated functions at C-6 are reported. Relative substituent effects are discussed. ...

journal_title：Steroids

authors： Doller D,Gros EG

更新日期：1991-04-01 00:00:00

abstract：:We describe a novel steroid, which we have named "Ionotropin". Its unique features are: [1] it has 23 carbon atoms and [2] it is a phosphocholine ester. There are no other known mammalian steroids with either structural feature. Ionotropin cross reacts with digoxin-specific antibodies and may be the long-sought, endog...

journal_title：Steroids

authors： Chasalow F,Pierce-Cohen L

更新日期：2018-08-01 00:00:00

abstract：:Steroid hormones are involved in the regulation of a variety of processes like embryonic development, sex differentiation, metabolism, immune responses, circadian rhythms, stress response, and reproduction in vertebrates. Teleost fishes and humans show a remarkable conservation in many developmental and physiological ...

journal_title：Steroids

authors： Tokarz J,Möller G,Hrabě de Angelis M,Adamski J

更新日期：2015-11-01 00:00:00

abstract：:Starting from the structure of ice (in which each water molecule is surrounded by other four water molecules forming a tetrahedron with a value of 4.51Å for the edge O-O distance), and the knowledge that this value also corresponds to the O7-O12 distance of the skeleton of cholic acid, it is hypothesized that two ster...

journal_title：Steroids

authors： Soto VH,Alvarez M,Meijide F,Trillo JV,Antelo A,Jover A,Galantini L,Tato JV

更新日期：2012-10-01 00:00:00