Abstract：
:Labeled beta-muricholic acid was obtained from germfree rats given [24-14C]-chenodeoxycholic acid. It was crystallized with the same unlabeled bile acid extracted from germfree rat pooled biles. Five patients fitted with a T-tube after cholecystectomy were given orally 100 mg of the bile acid. Metabolites of beta-muricholic acid in bile, urine and feces were studied. Glyco- and tauro-beta-muricholic acid were the only metabolites detected in bile. The urinary bile acid pattern was complex and included free, glyco- and sulfoconjugated beta-muricholic acid, but no glucuronide was observed. Analysis of fecal bile acid showed very few metabolites: the 3 beta-epimer was identified; the 6 beta- and 7 beta-hydroxyls were apparently not transformed by human intestinal microflora.
journal_name
Steroidsjournal_title
Steroidsauthors
Sacquet E,Parquet M,Riottot M,Raizman A,Nordlinger B,Infante Rdoi
10.1016/0039-128x(85)90006-6subject
Has Abstractpub_date
1985-05-01 00:00:00pages
411-26issue
5eissn
0039-128Xissn
1878-5867pii
0039-128X(85)90006-6journal_volume
45pub_type
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