当前位置： SCI文献检索 > STEROIDS期刊下所有文献 > Bioassay-guided isolation and identification of anti-ulcer ecdysteroids from the seeds of Sphenocentrum jollyanum Pierre (Menispermaceae).

Bioassay-guided isolation and identification of anti-ulcer ecdysteroids from the seeds of Sphenocentrum jollyanum Pierre (Menispermaceae).

Abstract：

:Sphenocentrum jollyanum seeds (MeOH extract and n butanol fraction) exhibited urease inhibitory activity (IC50 40.0 ± 0.92, 28.6 ± 0.41). The Ethyl acetate (EtOAc) fraction gave significant antacid activity with an increase in the baseline pH value of 1.2 to 1.61 ± 0.00 and 1.53 ± 0.00 at 50 and 100 mg, respectively, compared to the antacid activity of sodium bicarbonate (1.53 ± 0.00, 1.47 ± 0.00). Five known ecdysteroid compounds isolated from S. jollyanum ethyl acetate and n butanol fractions are Pinnatasterone (1), Polypodine B (2), 20-hydroxyecdysone (3), 20, 26-dihydroxyecdysone, (4) and Atrotosterone A (5). The compounds' structures were determined using extensive 1D and 2D NMR experiments, and the molecular mass for each of the compounds was confirmed by FAB-MS. Compounds 1-5 were evaluated for their urease inhibitory and antacid activities. Fractions were active in comparison with the standard drug acetohydroxamic acid, and sodium bicarbonate, respectively. Compounds 2, 3 and 1 showed significant urease inhibitory activity (IC50 7.0 ± 0.56, 13.8 ± 0.49 and 14.1 ± 0.59), respectively. The activity of compounds 4 and 5 were moderate compared to that of acetohydroxamic acid (IC50 value 20.3 ± 0.43). Very few compounds have been isolated from this plant despite the numerous biological activities reported for it. The antacid and urease inhibitory activities of this plant and isolated compounds are described for the first time.

journal_name

Steroids

journal_title

Steroids

authors

Akinwumi IA,Sonibare MA,Yeye EO,Khan M

doi

10.1016/j.steroids.2020.108636

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

108636

eissn

0039-128X

issn

1878-5867

pii

S0039-128X(20)30061-1

journal_volume

159

pub_type

杂志文章

相关文献

STEROIDS文献大全
  • Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review.

    abstract：:Anabolic androgenic steroids (AAS) are testosterone and testosterone-derivative compounds sporadically employed by athletes and increasingly used recreationally to acquire a competitive edge or improve body composition. Nevertheless, users are subject to undesired side effects majorly associated with tissue-specific a...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/j.steroids.2020.108753

    authors： Machek SB,Cardaci TD,Wilburn DT,Willoughby DS

    更新日期：2020-12-01 00:00:00

  • Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells.

    abstract：:Glucocorticoids are an important class of anti-inflammatory/immunosuppressive drugs. A crucial part of their anti-inflammatory action results from their ability to repress proinflammatory transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) upon binding to the glucocorticoid receptor ...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2014.04.003

    authors： Cechin SR,Buchwald P

    更新日期：2014-07-01 00:00:00

  • Cardiac effects of aldosterone: does gender matter?

    abstract：:Ischemic heart disease (IHD) continues to be the most common cause of death globally, although mortality rates are decreasing with significant advances in treatment. Higher prevalence of co-morbidities in women only partly explains the lack of decrease in mortality rates in younger women due to. Until recently there h...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/j.steroids.2014.08.013

    authors： Mihailidou AS,Ashton AW

    更新日期：2014-12-01 00:00:00

  • All progestins are not created equal.

    abstract：:A variety of progestins are available for therapeutic use. It is convenient to classify them into those related in chemical structure to progesterone or testosterone. Progestins related to progesterone can be subdivided into pregnanes and 19-norpregnanes, whereas those related to testosterone can be subdivided into th...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/j.steroids.2003.08.003

    authors： Stanczyk FZ

    更新日期：2003-11-01 00:00:00

  • Reference intervals of urinary steroid metabolites using gas chromatography-mass spectrometry in Chinese adults.

    abstract：BACKGROUND:Urinary steroid profiling by GC or GC-MS are established clinical tools to complement other biochemical tests in the diagnosis and investigation of a wide range of adrenocortical disorders, but normative data on adults using the more specific GC-MS are lacking. Our objective was to set up the reference inter...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2008.03.004

    authors： Chan AO,Taylor NF,Tiu SC,Shek CC

    更新日期：2008-09-01 00:00:00

  • Saturated fatty acid exposure induces androgen overproduction in bovine adrenal cells.

    abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is mainly defined by hyperandrogenemia, from ovarian and adrenal origin, and is characterized by insulin resistance (IR). Studies found that raising in vivo non-esterified fatty acid (NEFA) levels, which induces lipotoxicity, increases androgen levels and IR. The aim of this ...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2011.12.017

    authors： Bellanger S,Battista MC,Fink GD,Baillargeon JP

    更新日期：2012-03-10 00:00:00

  • 1H and 13C NMR characteristics of synthetic derivatives of steroid sapogenins. Part III. 16Beta,23:23,26-diepoxy side chains.

    abstract：:The full assignments of the (1)H and (13)C NMR signals of steroids bearing the 16beta,23:23,26-diepoxy side chain are provided. Differentiation of the diasterotopic H-26 pair was achieved with the aid of NOESY experiments. The main substituent and steric effects associated with this moiety and their influence on the c...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2008.01.027

    authors： Vázquez-Ramírez I,Macías-Alonso M,Arcos-Ramos RO,Ruíz-Pérez KM,Solano-Ramírez DO,Iglesias Arteaga MA

    更新日期：2008-07-01 00:00:00

  • An enzyme immunoassay of estrone in swine serum.

    abstract：:An enzyme immunoassay for estrone in swine serum was established. For this, beta-galactosidase from E. coli was conjugated through estrone-17 (O-carboxymethyl)oxime using a mixed anhydride reaction. The percentage of immunoreactive estrone-17 (O-carboxymethyl)oxime-beta-galactosidase conjugate was estimated to be abou...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/0039-128x(82)90136-2

    authors： Tamamura F,Nakao T,Tsunoda N,Kawata K

    更新日期：1982-06-01 00:00:00

  • Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals.

    abstract：:Glycyrrhizic acid (GZA) and glycyrrhetinic acid (GRA) can be determined rapidly and precisely by high-performance liquid chromatography (HPLC) in biological fluids and tissues from experimental animals and humans. From plasma and tissues, GZA and GRA are extracted by organic solvents and the extracts can directly be u...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/0039-128x(94)90088-4

    authors： Krähenbühl S,Hasler F,Krapf R

    更新日期：1994-02-01 00:00:00

  • The challenge of continuous exogenous glucocorticoid administration in mice.

    abstract：BACKGROUND:Chronic administration of exogenous glucocorticoids is often required in experimental research. We compared the efficacy and reliability of three different methods of continuous glucocorticoid administration in mice. MATERIALS AND METHODS:Male CD1 Swiss White mice aged 7-9 weeks received corticosterone (CS)...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2008.11.009

    authors： Herrmann M,Henneicke H,Street J,Modzelewski J,Kalak R,Buttgereit F,Dunstan CR,Zhou H,Seibel MJ

    更新日期：2009-02-01 00:00:00

  • Immunochemical detection of 5 alpha-reductase in human serum.

    abstract：:This study represents a continuing effort to find a new biomarker for the diagnosis and management of prostatic cancer. Polyclonal antibodies were prepared to a peptide (CAKP) representing amino acids 28 to 43 of the 5 alpha-reductase type 2 isozyme. Using immunoaffinity-purified antibodies, the sera of 62 patients we...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/s0039-128x(96)00184-5

    authors： Lombardo ME,Hudson PB

    更新日期：1996-11-01 00:00:00

  • Dehydroepiandrosterone fatty acyl esters in high density lipoprotein: interaction with human vascular endothelial cells and vascular responses ex vivo.

    abstract：:Dehydroepiandrosterone (DHEA) fatty acyl esters once incorporated in high density lipoprotein (HDL) induce a stronger vasodilatory response in rat mesenteric arteries ex vivo compared to native HDL. We studied the role of HDL receptor, scavenger receptor class B, type 1 (SR-B1), as well as estrogen and androgen recept...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2010.12.007

    authors： Paatela H,Vihma V,Jauhiainen M,Mervaala E,Tikkanen MJ

    更新日期：2011-03-01 00:00:00

  • A novel sterol from Chinese truffles Tuber indicum.

    abstract：:From the fruiting bodies of Ascomycetes Tuber indicum, a new steroidal glucoside with polyhydroxy ergosterol nucleus, tuberoside (2), has been isolated along with additional four known ergosterol derivatives, (22E, 24R)-ergosta-7, 22-dien-3beta, 5alpha, 6beta-triol (1), 5alpha, 8alpha-epidioxy-(22E, 24R)-ergosta-6, 22...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/s0039-128x(01)00105-2

    authors： Jinming G,Lin H,Jikai L

    更新日期：2001-10-01 00:00:00

  • 6E-hydroximinosteroid homodimerization by cross-metathesis processes.

    abstract：:A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), col...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2007.03.014

    authors： Rega M,Jiménez C,Rodríguez J

    更新日期：2007-10-01 00:00:00

  • In human T cells mifepristone antagonizes glucocorticoid non-genomic rapid responses in terms of Na(+)/H(+)-exchange 1 activity, but not ezrin/radixin/moesin phosphorylation.

    abstract：:Glucocorticoids (GCs) and progesterone have been employed as immunosuppressive agents during pregnancy for many years. Intracellular acidification by GCs is due to a rapid non-genomic inhibition of membrane Na(+)/H(+)-exchange 1 (NHE1) activity and is followed by immunosuppression of PHA-stimulated proliferation. NHE1...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2016.01.004

    authors： Chien EJ,Hsu CH,Chang VH,Lin EP,Kuo TP,Chien CH,Lin HY

    更新日期：2016-07-01 00:00:00

  • Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: protective effect of 17 beta-estradiol.

    abstract：:Oxidative stress is thought to play a crucial role in the pathogenesis of chronic diabetic complications. We investigated the protective effects of 17 beta-estradiol (E2) on alloxan-induced stress oxidant, hepatic dysfunction and histological changes in male rats liver and pancreas. Our results showed that 17 beta-est...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2007.12.026

    authors： Hamden K,Carreau S,Boujbiha MA,Lajmi S,Aloulou D,Kchaou D,Elfeki A

    更新日期：2008-05-01 00:00:00

  • Metabolomic profiling of five Agave leaf taxa via UHPLC/PDA/ESI-MS inrelation to their anti-inflammatory, immunomodulatory and ulceroprotective activities.

    abstract：:Agave plants are popular for their myriad applications in traditional medicine attributed to their reported anti-inflammatory, immunomodulatory, cytotoxic and antifungal activities. The aim of this study was to examine the anti-inflammatory, immunomodulatory and ulceroprotective activity of Agave species in relation t...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2020.108648

    authors： El-Hawary SS,El-Kammar HA,Farag MA,Saleh DO,El Dine RS

    更新日期：2020-08-01 00:00:00

  • Aldosterone: the minority hormone of the adrenal cortex.

    abstract：:In comparison with the glucocorticoids cortisol and corticosterone, the mineralocorticoid aldosterone is a minority hormone of the mammalian adrenal cortex, and its proper function is dependent upon protective physiological mechanisms. These include a particular site of aldosterone synthesis in zona glomerulosa cells ...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/0039-128x(94)00021-4

    authors： Müller J

    更新日期：1995-01-01 00:00:00

  • Mass spectrometry and stability of t-butyldimethylsilylethers of some estrogens and androstanes.

    abstract：:In addition to using radioimmunoassays for the determination of estrogens and other steroids, the possibility of using mass fragmentography for analysis was investigated. t-Butyldimethylsilyl chloride was selected as a reagent for derivatisation because it forms rather stable silylethers. In all the mass-spectra obrai...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/0039-128x(79)90013-8

    authors： Ballhorn L,Mueller WF,Korte F

    更新日期：1979-04-01 00:00:00

  • Biotransformation of progestonic hormone dydrogesterone with Macrophomina phaseolina, and study of the effect of biotransformed products on phagocytes oxidative burst.

    abstract：:Biotransformation of a synthetic progestonic hormone dydrogesterone (1), C21H28O2, with a plant pathogenic fungus Macrophomina phaseolina yielded two new 2 and 3, and a known 4 metabolites. These analogues were identified as, 3β,11α-dihydroxy-5β,9β,10α-pregna-7-ene-6,20-dione (2), 15β-hydroxy-9β,10α-pregna-4,6-diene-3...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2018.12.009

    authors： Wajid A,Ahmad MS,Yousuf S,Atia-Tul-Wahab,Jabeen A,Atta-Ur-Rahman,Choudhary MI

    更新日期：2019-03-01 00:00:00

  • Structure-activity relationship of brassinosteroids and their agricultural practical usages.

    abstract：:Brassinosteroids (BRs) control several important agronomic traits, such as strengthening resistance to diverse adversity, improving the quality, and increasing crop yield. Their chemical structures and varieties, specific methods for the evaluation of bioactivities, structure-activity relationships, potential novel co...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/j.steroids.2017.05.005

    authors： Liu J,Zhang D,Sun X,Ding T,Lei B,Zhang C

    更新日期：2017-08-01 00:00:00

  • Progesterone receptors in endometrial cancer invasion and metastasis: development of a mouse model.

    abstract：:Progestagens inhibit growth of endometrial cancer cells in vivo and in vitro, and also are reported to inhibit endometrial cancer cell invasion. The progesterone receptor (PR) isotypes PRA and PRB have different transcriptional activity. There are indications that relative over expression of PRB could lead to developm...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/j.steroids.2003.08.002

    authors： Hanekamp EE,Gielen SC,van Oosterhoud SA,Burger CW,Grootegoed JA,Huikeshoven FJ,Blok LJ

    更新日期：2003-11-01 00:00:00

  • Cholecalciferol sulfate identification in human milk by HPLC.

    abstract：:Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitam...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/0039-128x(82)90063-0

    authors： Boulch NL,Cancela L,Miravet L

    更新日期：1982-04-01 00:00:00

  • Distribution and metabolism of F6-1,25(OH)2 vitamin D3 and 1,25(OH)2 vitamin D3 in the bones of rats dosed with tritium-labeled compounds.

    abstract：:26,26,26,27,27,27-Hexafluo-1,25(OH)2 vitamin D3, the hexafluorinated analog of 1,25(OH)2 vitamin D3, has been reported to be several times more potent than the parent compound regarding some vitamin D actions. The reason for enhanced biologic activity in the kidneys and small intestine appears to be related to F6-1,25...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/s0039-128x(98)00055-5

    authors： Komuro S,Kanamaru H,Nakatsuka I,Yoshitake A

    更新日期：1998-10-01 00:00:00

  • Molecular analysis of 11 beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess.

    abstract：:The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of hypertension in which 11 beta-hydroxysteroid dehydrogenase (11-HSD) is defective. This enzyme converts cortisol to its inactive metabolite, cortisone. The deficiency allows mineralocorticoid receptors to be occupied by cortisol, because th...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/s0039-128x(96)00164-x

    authors： White PC,Mune T,Rogerson FM,Kayes KM,Agarwal AK

    更新日期：1997-01-01 00:00:00

  • Steroid dimer formation: metal reduction of methyl androst-4-ene-3, 17-dion-19-oate.

    abstract：:Two isomeric dimeric steroids, 3,3'-bis(methyl 3-hydroxyandrost-4-en-17-on-19-oate-3-yl), with symmetrical (alpha, alpha') and unsymmetrical structures (alpha,beta'), have been obtained by reduction of methyl androst-4-ene-3,17-dion-19-oate with zinc in aqueous acetic acid together with the major products, the isomeri...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/s0039-128x(99)00108-7

    authors： Templeton JF,Majgier-Baranowska H,Marat K

    更新日期：2000-04-01 00:00:00

  • Synthesis of 11 alpha-hydroxyprogesterone haptens.

    abstract：:C-4 and C-6 bridged haptens of 11 alpha-hydroxyprogesterone, an anti-androgen, were respectively synthesized via 4, 5 and 5 alpha, 6 alpha epoxide ring openings using 3-mercaptopropanoic acid. Substitution of 6-bromo derivative of progesterone using the same reagent unexpectedly afforded a C-4 substituted product inst...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/0039-128x(89)90063-9

    authors： Yoshida H,Nakai S,Nimbari F,Yoshimoto K,Nishimura T

    更新日期：1989-06-01 00:00:00

  • From ligand structure to biological activity: modified estratrienes and their estrogenic and antiestrogenic effects in MCF-7 cells.

    abstract：:A variety of compounds, including the selective estrogen receptor (ER) modulators tamoxifen and raloxifene, phytoestrogens such as genistein, and xenoestrogens such as bisphenol, bind to the estrogen receptor and elicit biological responses. Structural studies have linked the altered activity of compounds such as 4-hy...

    journal_title：Steroids

    pub_type： 杂志文章,评审

    doi：10.1016/j.steroids.2004.03.014

    authors： Brooks SC,Skafar DF

    更新日期：2004-06-01 00:00:00

  • Structure-activity relationships of progesterone derivatives that bind to the digitalis receptor: modifications in A and B rings.

    abstract：:A number of progesterone derivatives, having a 17 alpha-acetoxy group and various functions at C-3 and C-6, interact at the cardiac glycoside (CG) binding site, using [3H]ouabain in a radioligand binding assay (RBA) with membranes from dog myocardium. We now report on results of structure-activity studies concerned wi...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/0039-128x(87)90012-2

    authors： Templeton JF,Kumar VP,Kim RS,LaBella FS

    更新日期：1987-04-01 00:00:00

  • Rat luminal cell nuclear area changes correlated with uterine growth responses induced by a low dose infusion or injection of estradiol-17 beta.

    abstract：:Rat uterine luminal epithelial cells (LEC) responded differently when exposed to an injection of 1.0 microgram estradiol-17 beta (E2) compared to a continuous infusion of E2 at the rate of 1.0 microgram/24 hours. After injection or beginning infusion, LEC mean nuclear area significantly decreased by 4 h, then increase...

    journal_title：Steroids

    pub_type： 杂志文章

    doi：10.1016/0039-128x(85)90017-0

    authors： Lavia LA,Roberts DK,Walker NJ,Anderson K

    更新日期：1985-06-01 00:00:00