Abstract:
:A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), colon adenocarcinoma HCT-116 (ATCC CCL-247), human caucasian glioblastoma multiforme T98G (ECACC 92090213) and human pancreatic adenocarcinoma PSN1 (ECACC 94060601) tumour cells. Homodimer 10b presented selective activity against HCT-116, although they are not highly toxic when compared with the monomer counterparts.
journal_name
Steroidsjournal_title
Steroidsauthors
Rega M,Jiménez C,Rodríguez Jdoi
10.1016/j.steroids.2007.03.014subject
Has Abstractpub_date
2007-10-01 00:00:00pages
729-35issue
11-12eissn
0039-128Xissn
1878-5867pii
S0039-128X(07)00058-Xjournal_volume
72pub_type
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