Heterocyclic steroids-part VIII: Studies on the total synthesis of racemic 2-phenyl-7-methyl-3-oxa-A-nor-14 beta-estra-1,5(10),6,8-tetraen-17 alpha-ol.

abstract：:Over the past 30 years, numerous studies in invertebrates and vertebrates have established a role of calcium in oocyte maturation as well as in the resumption and progression of follicular development. Polycystic ovarian syndrome (PCO) is characterized by hyperandrogenic chronic anovulation, theca cell hyperplasia, an...

journal_title：Steroids

authors： Thys-Jacobs S,Donovan D,Papadopoulos A,Sarrel P,Bilezikian JP

更新日期：1999-06-01 00:00:00

abstract：:An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The abso...

journal_title：Steroids

authors： Jia P,Wu X,Yu Y,Zhang G

更新日期：2009-02-01 00:00:00

abstract：:Spermatozoa from bovine ejaculates and cauda epiditymidis were incubated with either tritiated 17 beta-hydroxy-5 alpha-androstane-3-one (DHT) or 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). Examination of the medium incubations demonstrated metabolic conversion of both DHT and 3 alpha-diol when these steri...

journal_title：Steroids

authors： Djöseland O,Høglo S,Nyberg K,Hastings CD,Attramadal A

更新日期：1978-03-01 00:00:00

abstract：:A first assay based on stable isotope dilution/gas chromatography-mass spectrometry (ID/GC-MS) has been developed for plasma 11-deoxycortisol (Reichstein's compound S), the leading hormonal marker of 11beta-hydroxylase deficiency. A suitable internal standard being unavailable, we synthesized dideuterated 11-deoxycort...

journal_title：Steroids

authors： Wudy SA,Hartmann M,Homoki J

更新日期：2002-09-01 00:00:00

abstract：:Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Am...

journal_title：Steroids

authors： Chi GF,Sop RVT,Mbaveng AT,Omollo Ombito J,Fotso GW,Nguenang GS,Kuete V,Efferth T,Ngadjui BT

更新日期：2020-11-01 00:00:00

abstract：:Three new polyhydroxysterols, named muriflasteroids A-C (1-3) were isolated from the South China Sea gorgonian Muriceopsis flavida, together with sixteen known analogs, cholest-3β,5α,6β-triol,3β-acetate (4), 5α-methoxycholest-3β,6β-diol (5), (22E)-cholest-22-en-3β,5α,6β-triol (6), cholest-3β,5α,6β-triol (7), (22E)-24-...

journal_title：Steroids

authors： Liu TF,Lu X,Tang H,Zhang MM,Wang P,Sun P,Liu ZY,Wang ZL,Li L,Rui YC,Li TJ,Zhang W

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:ERα36 is a recently cloned variant of estrogen receptor-alpha which has been proved to play an active role in a series of malignant diseases. METHOD:ERα36 expression was examined using immunohistochemical methods with sections from 126 resected NSCLC specimens. The immunoreactivity of ERα66 was also studi...

journal_title：Steroids

authors： Zhang S,Qiu C,Wang L,Liu Q,Du J

更新日期：2014-09-01 00:00:00

abstract：:The importance of computer-aided drug design and development is clear nowadays. These approaches smooth the way of designing some efficient candidates based on drugs in use. At this place, we studied the mechanism of D4-abiraterone (D4A), the active metabolite of Abiraterone (Abi), binding to CYP17A1 compared with Abi...

journal_title：Steroids

authors： Mehralitabar H,Ghasemi AS,Gholizadeh J

更新日期：2021-01-17 00:00:00

abstract：:Eleven new 14,15-seco-pregnane-type steroidal glycosides, cynanosides P1-P5, Q1-Q3, R1-R3, and a novel 12,13-seco-14,18-nor-pregnane-type steroidal glycoside, cynanoside S, were isolated from the roots of Cynanchum atratum, together with four known compounds, atratoside C, sublanceoside E3, chekiangensoside C and cyna...

journal_title：Steroids

authors： Bai H,Li W,Asada Y,Satou T,Wang Y,Koike K

更新日期：2009-02-01 00:00:00

abstract：:The effect of steroids contained in oral contraceptives, namely ethinylestradiol:17 alpha-ethinyl-1,3,5,(10)-estratriene-3, 17-diol (E) and norethindrone acetate:17 beta-acetoxy-17-ethinyl-4-estren-3-one (N), on cell replication and human chorionic gonadotropin (hCG) secretion by choriocarcinoma cells in monolayer cul...

journal_title：Steroids

authors： Gal D,Simpson ER,Porter JC,MacDonald PC,Buchsbaum HJ

更新日期：1981-06-01 00:00:00

abstract：:The structure of dehydro-oogoniol (3 beta,11 alpha,15 beta,29-tetrahydroxystigmasta-5,24(28)(E)-dien-7-one), a female-activating hormone of the water mold Achlya, has been confirmed by synthesis. The starting material was progesterone, which was converted to the 11 alpha, 15 beta-dihydroxy derivative by microbiologica...

journal_title：Steroids

authors： McMorris TC,Le PH,Preus MW,Schow SR,Weihe GR

更新日期：1989-03-01 00:00:00

abstract：:The receptor profiles and in vivo activity of tibolone, and its primary metabolites, Delta(4)-isomer, and 3alpha- and 3beta-hydroxytibolone, were studied and compared to those of structurally related compounds. The Delta(4)-isomer was the strongest binder and activator of the progesterone receptor (PR); tibolone was 1...

journal_title：Steroids

authors： de Gooyer ME,Deckers GH,Schoonen WG,Verheul HA,Kloosterboer HJ

更新日期：2003-01-01 00:00:00

abstract：:The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12 beta-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17 beta-hydroxy-12 beta-methyl-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn-3-one (37) and...

journal_title：Steroids

authors： Broess AI,van Vliet NP,Groen MB,Hamersma H

更新日期：1992-11-01 00:00:00

abstract：:We synthesized 22-fluorovitamin D3 from (22S) cholest-5-ene-3 beta, 22-diol-3 beta-acetate 2. Compound 2 was treated with diethylaminosulfur trifluoride to give 22-fluorocholest-5-en-3 beta-acetate 3 and (E) 22-dehydrocholest-5-en-3 beta-acetate. Compound 3 was treated with N-bromosuccinimide to give a mixture of the ...

journal_title：Steroids

authors： Gill HS,Londowski JM,Corradino RA,Kumar R

更新日期：1986-07-01 00:00:00

abstract：:For the purpose of describing the pathway by which estrones are synthesized in the rhesus monkey (Macaca mulatta) corpus luteum (CL), CL were obtained during the midluteal phase of the menstrual cycle and fragments incubated with equimolar amounts of [7-3H]pregnenolone plus [4-14C]progesterone. Metabolites including 3...

journal_title：Steroids

authors： Sholl SA,Wolf RC

更新日期：1980-08-01 00:00:00

abstract：:Three protein fractions of the cytosol of the chick parathyroid glands, which had the sedimentation constants of 2.5 S, 3.7 S and 5.5 S, were found to bind with 1 alpha,25-dihydroxyvitamin D3. Among these proteins, the 3.7 S protein was assumed to be the specific receptor protein. The 3.7 S receptor protein was also ...

journal_title：Steroids

authors： Ishizuka S,Bannai K,Naruchi T,Hashimoto Y

更新日期：1982-01-01 00:00:00

abstract：:The condensation of O-substituted hydroxylamines with conjugated 3-oxo-4-en steroids results in a mixture of syn-anti configurations. Syn-anti ratios are influenced by sterical hindrance between the oximino substituents (e.g. O-benzyl) and the steroidal skeleton. Stereostructures and isomeric ratios were proved by det...

journal_title：Steroids

authors： Sohár P,Bodor A,Schwartz R

更新日期：1999-04-01 00:00:00

abstract：:The synthesis of the esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) with three bile acids and of the cholesteryl carbonate of norethisterone are described. :This article reports the synthesis of the esters of norethisterone (17 alpha-ethynl-17beta-hydroxyestr-4-en-3-one) with 3 bile acids ...

journal_title：Steroids

authors： Herz JE,Sandoval J

更新日期：1983-03-01 00:00:00

abstract：:To reduce the variability in estradiol (E2) testing and to assure better patient care, standardization of E2 measurements has been recommended. This study aims to assess the accuracy and variability of E2 measurements performed by 11 routine immunological methods and 6 mass spectrometry methods using single donor seru...

journal_title：Steroids

authors： Vesper HW,Botelho JC,Vidal ML,Rahmani Y,Thienpont LM,Caudill SP

更新日期：2014-04-01 00:00:00

abstract：:Using 1 alpha,2 alpha-oxido-cholesta-5,7-diene-3 beta,25-diol (2) as a starting material, the provitamins of calcitriol with an additional 2 beta-chloro-, 2 beta-fluoro-, and 2 beta-methoxy-substituent (3,4,5) are obtained by transdiaxial opening of the oxirane ring with nucleophiles. An efficient irradiation process ...

journal_title：Steroids

authors： Scheddin D,Mayer H,Schönecker B,Gliesing S,Reichenbächer M

更新日期：1998-12-01 00:00:00

abstract：:The hormone 1alpha,25(OH)2vitamin D3 (1,25-D) produces biological responses via both genomic and rapid mechanisms. The genomic responses are linked to a nuclear receptor, while the rapid responses are believed to utilize other signal transduction pathways that are likely linked to a putative cell membrane receptor for...

journal_title：Steroids

authors： Norman AW,Song X,Zanello L,Bula C,Okamura WH

更新日期：1999-01-01 00:00:00

abstract：:Novel C6-cyclo secondary amine substituted purine steroid-nucleoside analogues (2-9) were efficiently synthesized through displacement of the C6 chloro on the purine ring of series 1 with versatile cyclic secondary amines, including pyrrolidines, piperidine, morpholine, and piperazines. All the newly-synthesized compo...

journal_title：Steroids

authors： Huang LH,Li Y,Xu HD,Zheng YF,Liu HM

更新日期：2014-07-01 00:00:00

abstract：:The inhibition of testosterone 5alpha-reductase activity by 3-oxo-4-androstene-17beta-carboxylic acid in the male reproductive organs of the rat was demonstrated in vitro. The medium for incubation of caput epididymis showed the highest concentration of 5alpha-dihydrotestosterone (5alpha-DHT) whereas the highest conce...

journal_title：Steroids

authors： Saksena SK,Lau IF,Chang MC

更新日期：1976-06-01 00:00:00

abstract：:15alpha-Hydroxydehydroisoandrosterone and 15alpha-hydroxypregnenolone were isolated from hydrolyzed extracts of human late pregnancy urine and identified by means of the isotope dilution technique. In two separate determinations the excretion rate of 15alpha-hydroxydehydroisoandrosterone was found to be 1.7 and 3.2 mi...

journal_title：Steroids

authors： Stanczyk FZ,Stern M,Solomon S

更新日期：1978-05-01 00:00:00

abstract：:Bioassays were conducted to determine various endocrinological properties of two spirolactone derivatives, 4',5'-dihydrospiro-[estr-4-ene-17,2'(3'H)-furan]-3-one (Compound I) and dispiro[cyclopropane-1,6'-estr-4'-ene-17',2"(3"h)-furan]-3'-one (Compound II). They proved to be very potent estrogen antagonists in immatur...

journal_title：Steroids

authors： Brooks JR,Steelman SL,Patanelli DJ

更新日期：1977-06-01 00:00:00

abstract：:Spectroscopic examination of purified extracts of the rumen content of sheep intoxicated by Brachiaria decumbens revealed the presence of two spirostanes, identified as epi-sarsasapogenin and epi-smilagenin. Sarsasapogenone was obtained by the oxidation of sarsasapogenin. The reduction of sarsasapogenone using lithium...

journal_title：Steroids

authors： Lajis NH,Abdullah AS,Salim SJ,Bremner JB,Khan MN

更新日期：1993-08-01 00:00:00

abstract：:Novel deoxycholic acid (DCA) derivatives were stereoselectively synthesised with -OH and -CH2SR moieties at the C-3 position, where R was a substituted aryl [2-aminophenyl (8) or 4-chlorophenyl (9)] or hetaryl [1-methylimidazolyl (5), 1,2,4-triazolyl (6), 5-amino-1,3,4-thiadiazolyl (7), pyridinyl (10) or pyrimidinyl (...

journal_title：Steroids

authors： Popadyuk II,Markov AV,Morozova EA,Babich VO,Salomatina OV,Logashenko EB,Zenkova MA,Tolstikova TG,Salakhutdinov NF

更新日期：2017-11-01 00:00:00

abstract：:To determine the sensitivity of the overnight 1-mg dexamethasone suppression test in diagnosing Cushing's syndrome, we evaluated the cortisol responses of 55 subjects (25 non-obese individuals with body mass index less than 25 kg/m2, 20 obese individuals with body mass index greater than 30 kg/m2, and 10 patients with...

journal_title：Steroids

authors： Fok AC,Tan KT,Jacob E,Sum CF

更新日期：1991-11-01 00:00:00

abstract：:We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormo...

journal_title：Steroids

authors： Taylor MK,Kviatkovsky SA,Hernández LM,Sargent P,Segal S,Granger DA

更新日期：2016-06-01 00:00:00

abstract：:A new synthesis of both epimeric forms of 26-cholestanoic acids and 26-alcohols containing a 3beta-hydroxy-Delta(5)- or a Delta(4)-3-keto-functionality in ring A is described starting from stigmasterol or (20S)-3beta-acetoxy-pregn-5-en-20-carboxylic acid. The obtained compounds are useful as standards for studies of c...

journal_title：Steroids

authors： Khripach VA,Zhabinskii VN,Konstantinova OV,Khripach NB,Antonchick AV,Antonchick AP,Schneider B

更新日期：2005-07-01 00:00:00