Abstract:
:15alpha-Hydroxydehydroisoandrosterone and 15alpha-hydroxypregnenolone were isolated from hydrolyzed extracts of human late pregnancy urine and identified by means of the isotope dilution technique. In two separate determinations the excretion rate of 15alpha-hydroxydehydroisoandrosterone was found to be 1.7 and 3.2 microgram per day while that of 15alpha-hydroxypregnenolone was 1.7 and 2.9 microgram per day. It is postulated that 15alpha-hydroxydehydroisoandrosterone might serve as a precursor of 15alpha-hydroxylated estrogens already isolated from late pregnancy urine. Similarly, 15alpha-hydroxypregnenolone might be an endogenous precursor of 15alpha-hydroxyprogesterone.
journal_name
Steroidsjournal_title
Steroidsauthors
Stanczyk FZ,Stern M,Solomon Sdoi
10.1016/s0039-128x(78)80002-6subject
Has Abstractpub_date
1978-05-01 00:00:00pages
613-26issue
5eissn
0039-128Xissn
1878-5867pii
S0039-128X(78)80002-6journal_volume
31pub_type
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