Abstract：
:Sex steroid-binding protein receptor was detected on membranes prepared from human premenopausal endometrium. The binding of sex steroid-binding protein to membranes was specific, saturable, and high affinity. Scatchard analysis showed the presence of two binding sites at different affinities. The addition of estradiol (10(-8) M) did not produce any inhibition of binding; indeed, it resulted in a modification of binding characteristics. The demonstration of sex steroid-binding protein receptor on membranes of human premenopausal endometrium indicates that the expression of receptor on membranes is not an effect of estrogen over stimulation on target tissues. Estradiol could act as a modulating factor of the binding, probably reflecting the sensitivity of tissues to different steroids.
journal_name
Steroidsjournal_title
Steroidsauthors
Fortunati N,Fissore F,Fazzari A,Berta L,Giudici M,Frairia Rdoi
10.1016/0039-128x(91)90058-4subject
Has Abstractpub_date
1991-06-01 00:00:00pages
341-6issue
6eissn
0039-128Xissn
1878-5867pii
0039-128X(91)90058-4journal_volume
56pub_type
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