Abstract：
:A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were investigated and optimized. In the straightforward route for preparation of UDCA, most of the reaction steps have high conversions with average yields of 91%, and overall yield up to 59% (6 steps) from the plant-source BA. Especially in the last step of reduction and hydrolysis, there are five functional groups converted with calcd 97% per conversion in one-pot reaction. This promising route offers economical and efficient strategies for potential large-scale production of UDCA.
journal_name
Steroidsjournal_title
Steroidsauthors
Wang J,Gu XZ,He LM,Li CC,Qiu WWdoi
10.1016/j.steroids.2020.108600subject
Has Abstractpub_date
2020-05-01 00:00:00pages
108600eissn
0039-128Xissn
1878-5867pii
S0039-128X(20)30025-8journal_volume
157pub_type
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