Abstract:
:The addition of molybdate to rabbit liver cytosol increased significantly the affinity of the glucocorticoid receptor for [3H] dexamethasone without influencing the concentration of binding sites. This effect was concentration dependent. Analysis of the binding data by curve-fitting and Scatchard plot revealed the occurrence of a complex binding process in the presence of molybdate. The pH-dependence curve of the binding was shifted towards alkaline values by the oxyanion. Taken together, these data suggest that molybdate exerts its effects via an interaction with the receptor molecule.
journal_name
Steroidsjournal_title
Steroidsauthors
Blanchardie P,Lustenberger P,Orsonneau JL,Denis M,Bernard Sdoi
10.1016/s0039-128x(84)90088-6subject
Has Abstractpub_date
1984-08-01 00:00:00pages
159-74issue
2eissn
0039-128Xissn
1878-5867pii
S0039-128X(84)90088-6journal_volume
44pub_type
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