Abstract:
:Steroid research at Lederle was initiated in 1946 and continued until about 1971. The areas of research interest involved primarily a study of delta 5,7-steroids, provitamin D3 variants, dehydroepiandrosterone variants, steroidal ketals, corticoids, and steroid conjugates. One of the principal goals was to develop novel antiinflammatory steroids for the treatment of, e.g., rheumatoid arthritis. A rational design led to the development of 16 alpha-hydroxycorticoids, culminating in the synthesis and therapeutic use of triamcinolone and related compounds.
journal_name
Steroidsjournal_title
Steroidsauthors
Bernstein Sdoi
10.1016/0039-128x(92)90083-lsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
392-402issue
8eissn
0039-128Xissn
1878-5867pii
0039-128X(92)90083-Ljournal_volume
57pub_type
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