Abstract:
:(20S)-[7,7,21,21-2H(4)]-3beta-(tert-Butyldimethylsilanyloxy)-20-methyl-pregn-5-en-21-ol, an intermediate for the preparation of deuterated isotopomers of sterols to be used as standards for biomedical studies, was prepared by reduction with dichloroaluminum deuteride of ethyl (20S)-3beta-(tert-butyldimethylsilanyloxy)-7-oxo-pregn-5-en-20-carboxylate. Using controlled experimental conditions, it has also been shown that the dichloroaluminum hydride reduction of a 7-keto steroid affords the corresponding 7beta-hydroxy derivative in a highly stereoselective manner.
journal_name
Steroidsjournal_title
Steroidsauthors
Ciuffreda P,Casati S,Bollini D,Santaniello Edoi
10.1016/s0039-128x(02)00172-1subject
Has Abstractpub_date
2003-02-01 00:00:00pages
193-8issue
2eissn
0039-128Xissn
1878-5867pii
S0039128X02001721journal_volume
68pub_type
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