Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal.

Abstract:

:In this paper, we studied the effect of heme availability on corticosterone and aldosterone synthesis in rat adrenal. We found that hemin stimulated corticosterone and aldosterone production in adrenal homogenates in a dose-dependent fashion. Hemin administration to rats also provoked an increase in both corticosterone and aldosterone content in adrenal. 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC), an inhibitor of liver ferrochelatase activity, was able to inhibit this enzyme in rat adrenal. This resulted in an impairment of heme concentration and consequently adrenal ALA-synthase and porphyrin content were increased. Thus, it was proven that DDC inhibits heme biosynthesis in adrenal as it does in liver. In vivo experiments with rats showed that DDC was able to partially blocked ACTH-mediated corticosterone and aldosterone production while hemin administration was able to partially restore it. These data indicate that heme availability affects steroid biosynthesis in rat adrenal.

journal_name

Steroids

journal_title

Steroids

authors

Martini CN,Vaena de Avalos SG,Romero DG,San Martín de Viale L,Vila Mde C

doi

10.1016/s0039-128x(97)00074-3

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

767-70

issue

12

eissn

0039-128X

issn

1878-5867

pii

S0039128X97000743

journal_volume

62

pub_type

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