Abstract:
:Two unnatural steroid sapogenins bearing a furospirostane side chain were prepared starting from the readily available spirostane sapogenins, tigogenin and diosgenin following a synthetic protocol that included: (i) introduction of a carbonyl group at position C-23, (ii) diacetoxyiodobenzene-induced F-ring contraction and (iii) LiAlH4 reduction of the newly emerged methoxycarbonyl moiety. The structures of the new compounds were corroborated by NMR and X-ray studies.
journal_name
Steroidsjournal_title
Steroidsauthors
Sánchez-Flores J,Romero-Ávila M,Rosado-Abón A,Flores-Álamo M,Iglesias-Arteaga MAdoi
10.1016/j.steroids.2013.05.013subject
Has Abstractpub_date
2013-09-01 00:00:00pages
798-802issue
9eissn
0039-128Xissn
1878-5867pii
S0039-128X(13)00123-2journal_volume
78pub_type
杂志文章相关文献
STEROIDS文献大全abstract::In our effort to develop imaging agents for brain glucocorticoid receptors, we have prepared several novel glucocorticoids possessing a 2-methylsulfanyl-acetyl side chain. The synthesis was accomplished via a Mitsunobu reaction with thiobenzoic acid starting from cortisol, prednisolone, dexamethasone and triamcinolone...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.08.013
更新日期:2008-01-01 00:00:00
abstract::7 beta-Methyl-chenodeoxycholic acid (7-MeCDC, 3 alpha, 7 alpha-dihydroxy-7 beta-methyl-5 beta-cholan-24-oic acid), 7 alpha-methyl-ursodeoxycholic acid (7-MeUDC, 3 alpha, 7 beta-dihydroxy-7 alpha-methyl-5 beta-cholan-24-oic acid), 7 xi-methyl-lithocholic acid (7-MeLC, 3 alpha-hydroxy-7 xi-methyl-5 beta-cholan-24-oic ac...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(84)80025-2
更新日期:1984-10-01 00:00:00
abstract::To simultaneously measure some targeted endocrine disruptors and several forms of sex hormones in rat serum, an accurate analytical procedure was developed. First, a comparison between a polymeric-based solid-phase extraction (SPE) and a micro-extraction by packed sorbent was performed to choose the optimal method to ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.10.011
更新日期:2015-12-01 00:00:00
abstract::The syntheses of 15beta-carboxyethylmercapto-5alpha-dihydrotestosterone, 15beta-carbosyethylmercapto-5alpha-androstane-3beta, 17beta-diol and 15beta-carboxyethylmercapto-5alpha-androstane-3alpha, 17beta-diol and the preparation of their bovine serum albumin (BSA) conjugates are described. These conjugates were employe...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90037-x
更新日期:1977-02-01 00:00:00
abstract::A virulent culture of Hymenoscyphus fraxineus, the causal agent of ash dieback, was investigated for its production of secondary metabolites in a 70 L batch fermentation. Chemical analysis of the mycelial extract by means of flash chromatography and preparative HPLC led to the isolation of a new ergostane-type steroid...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.03.007
更新日期:2018-07-01 00:00:00
abstract::Radioimmunoassay (RIA) for testosterone (T) in unchromatographed plasma extracts from ATD-treated rats gave spuriously high values for T. Cross-reaction and chromatographic studies subsequently showed that ATD and, to a much greater extent, its metabolite(s) were responsible for this overestimation. Celite column chro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90054-9
更新日期:1980-12-01 00:00:00
abstract::Plasma concentrations of dehydroepiandrosterone (DHEA), 5-androstene-3beta,17beta-diol (AED), and 17beta-estradiol (E2) in dairy cows and heifers and AED binding to uterine cytosolic estrogen receptor (ER) were studied. Plasma samples were collected from the subcutaneous abdominal (SA) and jugular (J) veins of heifers...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2003.12.001
更新日期:2004-02-01 00:00:00
abstract::The configurations at C-24 of 24-alkylsterols of six samples of Clerodendrum species (Verbenaceae) - the aerial parts of C. fragrans, C. inerme, C. infortunatum, C. scandens, and C. siphonanthus, and the seeds of C. infortunatum - were examined by NMR. All samples contained 24 beta-ethylsterols possessing a delta 25-b...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(89)90036-6
更新日期:1989-03-01 00:00:00
abstract::Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. Steroidal thiosemicarbazone derivatives were obtained...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.05.001
更新日期:2017-08-01 00:00:00
abstract::As demonstrated for pregnenolone, saturated ketones are conveniently alpha-hydroxymethylated by their transformation into a lithium enolate and by the reaction of the latter with formaldehydr. The 17-hydroxymethylpregnenolone prepared by this method in very good yield was readily converted to 17-hydroxymethylprogester...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(79)80021-5
更新日期:1979-11-01 00:00:00
abstract::The chemoselectivity of rigid cyclic alpha,beta-unsaturated carbonyl group on the reducing agents was influenced by the ring size and steric factor. Cholesterol (cholest-5-en-3beta-ol) and dehydroepiandrosterone (DHEA) were oxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form 1,4,6-cholestatrien-3-one and 1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2006.12.008
更新日期:2007-04-01 00:00:00
abstract:INTRODUCTION:ERα36 is a recently cloned variant of estrogen receptor-alpha which has been proved to play an active role in a series of malignant diseases. METHOD:ERα36 expression was examined using immunohistochemical methods with sections from 126 resected NSCLC specimens. The immunoreactivity of ERα66 was also studi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.05.021
更新日期:2014-09-01 00:00:00
abstract::Following i.v. administration of [4-14C]cortisol, various sulfate conjugated metabolites of cortisol in urine were identified and their respective excretion rates measured. The results obtained demonstrated the following: 1) sulfate conjugates as a group are excreted considerably slower than glucuronide conjugates; 2)...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(75)90034-3
更新日期:1975-06-01 00:00:00
abstract::The incorporation of the heterocycles into the steroid nucleus has been recognized as a useful strategy to develop new steroidal agents for disease treatment. Representative examples are abiraterone and galeterone, which are presently used in clinic for the treatment of advanced prostate cancers. Herein we have develo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108465
更新日期:2019-11-01 00:00:00
abstract::Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Am...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2020.108724
更新日期:2020-11-01 00:00:00
abstract::Reaction kinetics of the aromatase enzyme and of a new nonsteroidal aromatase inhibitor, R 76 713 (6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)-methyl]-1-methyl-1H- benzotriazole), were studied in ovarian homogenates obtained from pregnant mare's serum gonadotropin (PMSG)-injected female Wistar rats. The Km (Michaelis c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(90)90027-9
更新日期:1990-02-01 00:00:00
abstract::Due to their high profile biological activity, the steroids are among the most important secondary metabolites. A review of literature on the synthesis of pentacyclic steroids is presented. ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.04.005
更新日期:2008-09-01 00:00:00
abstract::Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo [2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yie...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.07.006
更新日期:2013-12-11 00:00:00
abstract::A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-pregn-4-en-20-yno (2,3-d) isoxazol-17-ol], a compound which also blocks recombination of free progester...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(79)90021-7
更新日期:1979-02-01 00:00:00
abstract::The synthesis of a radioiodinated diethylstilbestrol (DES) derivative is described. This derivative was prepared by coupling the previously synthesized active ester of 6-(4-O-diethylstilbestryl)hexanoic acid with mono-[125I]iodotyramine in dry tetrahydrofuran (20 to 22 C, 16 hours). The mono-[125I]iodotyramine was pre...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(92)90092-n
更新日期:1992-01-01 00:00:00
abstract::Bile acid salts are biosurfactants which form mixed micelles with phospholipids in vertebrates. These mixed micelles are suitable for solubilisation of cholesterol. For therapeutic purposes some bile acid salts as sodium ursocholate are used. However, bile acid anions possess low capacity for solubilisation of cholest...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.04.018
更新日期:2014-08-01 00:00:00
abstract::Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are act...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.11.010
更新日期:2014-03-01 00:00:00
abstract::Testosterone (17 beta -hydroxy-4-androsten-3-one ; T) and dihydrotestosterone (17 beta -hydroxy-5 alpha -androstan-3-one ; DHT) concentrations were determined by radioimmunoassay in different fetal tissues taken from male guinea-pigs. Androgen concentrations were maximal in the components of the Wolffian duct (vas def...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(81)90032-5
更新日期:1981-08-01 00:00:00
abstract::Based on the fact that timosaponin A-III (TA-III) exhibits potent cytotoxic effects and has been considered as a potential anti-tumor agent, a range of novel sarsasapogenin derivatives 1, 2a-2g, 3, 4, 5, 6a-6g have been synthesized by a simple and facile synthetic route. The in vitro cytotoxic activity of these synthe...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.09.007
更新日期:2015-01-01 00:00:00
abstract::Using cultured Y-1 mouse adrenal tumor cells which produce 20 alpha-hydroxy-4-pregnen-3-one (20-DHP), it was found that 0.01 mM corticosterone and deoxycorticosterone increased basal and inhibited ACTH-induced 20-DHP production during consecutive 30 and 120 min incubations. Steroid effects were concentration-dependent...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90026-1
更新日期:1985-07-01 00:00:00
abstract::Estrogen results in the suppression of experimental allergic encephalomyelitis (EAE), a frequently used experimental animal model of multiple sclerosis (MS). The mechanism by which estrogen acts in diseases with an autoimmune background is less clear. Here, we used splenic dendritic cells (DC) from the Lewis rats EAE ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.05.019
更新日期:2004-09-01 00:00:00
abstract::The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.04.011
更新日期:2008-10-01 00:00:00
abstract::A cytochrome P450-deficient mutant of the pathogenic fungus, Candida albicans, which accumulates exclusively 14 alpha-methylsterols in place of the normal end product sterol, ergosterol, was examined for alterations in membrane fluidity by electron paramagnetic resonance. The results using four nitroxyl spin labels in...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(89)90032-9
更新日期:1989-03-01 00:00:00
abstract::Prostaglandin E(2) (PGE(2)) is a major mediator in the pathophysiology, and pathogenesis of gynecological diseases associated with abnormal endometrial disease with proliferation and inflammation, such as endometriosis. In this study, we investigated the effect of dienogest, a selective progesterone receptor agonist, ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.08.010
更新日期:2011-01-01 00:00:00
abstract::Bile acid derivatives, with and without C-3 sulfate groups, and having either the diazo- or halomethylketone moieties, have been synthesized in good yield and purity. The synthetic sequence, COOH leads to COC1 leads to COCHN2 leads to COCH2X, was used with deoxycholic and cholic acids, which requires carefully control...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(79)90046-1
更新日期:1979-08-01 00:00:00