Abstract:
:The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of life, a group (n=11) received the diet supplemented with DHEA (0.5%, w/w), serving the rest (n=10) as controls. Body weight, body fat, serum lipids (triglycerides, total cholesterol and non-esterified fatty acids (NEFA)), HOMA index, n-6/n-3 polyunsaturated fatty acid (PUFA) ratios, serum adiponectin, leptin, resistin and TNF-alpha, as well as adiponectin expression in adipose tissue, were measured. A stepwise discriminant test was used to analyze these variables, and an index of overall metabolic risk was generated from them. DHEA treatment resulted in a significantly lower overall metabolic risk index, as generated by the discriminant test (P<0.01). The DHEA group had lower body fat and n-6/n-3 polyunsaturated fatty acid (PUFA) ratios than the control group (P<0.01), and the same trends were observed for serum cholesterol, triglycerides and HOMA index; in contrast, adiponectin expression in adipose tissue increased in DHEA-treated rats (P<0.05). The discriminant analysis revealed that adiponectin, both from serum and adipose tissue, was the most influencing factor, followed by n-6/n-3 ratios in adipose tissue, and by body fat. Our results then suggest that adiponectin is involved in the protective effect of DHEA against metabolic risk demonstrated in the present work.
journal_name
Steroidsjournal_title
Steroidsauthors
Pérez-de-Heredia F,Sánchez J,Priego T,Nicolás F,Portillo Mdel P,Palou A,Zamora S,Garaulet Mdoi
10.1016/j.steroids.2008.04.011subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1128-36issue
11eissn
0039-128Xissn
1878-5867pii
S0039-128X(08)00122-0journal_volume
73pub_type
杂志文章相关文献
STEROIDS文献大全abstract::Porcine sulfotransferase 2A1 (pSULT2A1) is a key enzyme involved in the testicular and hepatic sulfoconjugation of steroids such as dehydroepiandrosterone (DHEA) and potentially androstenone. This latter steroid is a major cause of boar taint, which is an unpleasant off-odour and off-flavour in pork from male pigs. Su...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.05.010
更新日期:2018-08-01 00:00:00
abstract::Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grou...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.06.012
更新日期:2010-12-01 00:00:00
abstract::Human progesterone receptor (PR) contains a polyproline motif in the amino-terminal domain that interacts with the SH3 domain of Src and mediates rapid activation of c-Src and downstream MAPK (Erk-1/-2) independent of the transcriptional activity of PR. Forcedly target PR to different locations in the cell by use of m...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.01.010
更新日期:2008-10-01 00:00:00
abstract::Tibolone is a highly effective postmenopausal hormone treatment that has its biological activity dependent on metabolism to 3alpha- and 3beta-OH tibolone, which bind solely to the estrogen receptor. Despite the high levels of estrogen receptor-binding metabolites in the circulation, the endometrium becomes atrophic, s...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.04.010
更新日期:2005-11-01 00:00:00
abstract::Cholesterol side-chain cleavage (CSCC) and aromatase activities were measured in luteal mitochondria and tissue pieces, respectively, from rhesus monkeys on days 22, 49, 128 and 160 of gestation. CSCC activity did not vary significantly during gestation and thus probably does not respond to chorionic gonadotropin whic...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90042-3
更新日期:1977-02-01 00:00:00
abstract::Preimplantation rabbit embryos were incubated with pregnenolone and dehydroisoandrosterone under conditions which gave formazan precipitation by the histochemical technique. The metabolic fate of the labeled steroids was assessed simultaneously. There was no concomitant transformation of pregnenolone to progesterone a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(81)80012-8
更新日期:1981-02-01 00:00:00
abstract::Aspergillus niger, one of fungal species most frequently used for experimental and industrial-scale biotransformations of various organic compounds, is generally known to transform steroids at 16β position. In this work, application of the strain A. niger KCH910 to bioconversion of dehydroepiandrosterone (DHEA), andro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.08.009
更新日期:2017-10-01 00:00:00
abstract::A cytochrome P450-deficient mutant of the pathogenic fungus, Candida albicans, which accumulates exclusively 14 alpha-methylsterols in place of the normal end product sterol, ergosterol, was examined for alterations in membrane fluidity by electron paramagnetic resonance. The results using four nitroxyl spin labels in...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(89)90032-9
更新日期:1989-03-01 00:00:00
abstract::Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate. This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated aklyl ethers of [7(m)-3...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90109-9
更新日期:1980-01-01 00:00:00
abstract::Immature hypophysectomized rats were injected with PMS; some groups received hCG 48h later. The C17,20-lyase activity in the granulosa cells removed from the large preovulatory follicles was estimated by the amount of labelled acetic acid produced from 21 (14C) progesterone or 17-hydroxyprogesterone. 17 alpha-hydroxyl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(83)90120-4
更新日期:1983-11-01 00:00:00
abstract::11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone, respectively, is an important pre-receptor signaling pathway for the renal mineralocorticoid receptor (MR). This receptor has an equal affinity for the glucocorti...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00024-7
更新日期:1995-01-01 00:00:00
abstract::The synthesis of (22E,24R)-5 alpha-ergosta-2,22-dien-6-one (2), a key intermediate to the preparation of 24-epibrassinolide (1), was achieved through the 3,6-diketone 8 in a 40% overall yield in five steps starting from ergosterol (3). ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00087-6
更新日期:1996-09-01 00:00:00
abstract::Synthesis, biochemical and biological testing of the first carborane derivatives of estrogens are described. Estrone 3-carboranylmethyl ether was synthesized in two steps from estrone. Reduction of estrone 3-carboranylmethyl ether with sodium borohydride provided estradiol-17 beta 3-carboranylmethyl ether. Enzyme kine...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(81)80020-7
更新日期:1981-02-01 00:00:00
abstract::The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the ster...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2006.12.006
更新日期:2007-03-01 00:00:00
abstract::Bioassays were conducted to determine various endocrinological properties of two spirolactone derivatives, 4',5'-dihydrospiro-[estr-4-ene-17,2'(3'H)-furan]-3-one (Compound I) and dispiro[cyclopropane-1,6'-estr-4'-ene-17',2"(3"h)-furan]-3'-one (Compound II). They proved to be very potent estrogen antagonists in immatur...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90123-4
更新日期:1977-06-01 00:00:00
abstract::Estrogen levels in breast tumors of post-menopausal women are as much as 10 times higher than estrogen levels in plasma, presumably due to in situ formation of estrogen. The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Thus, inhibitors...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00044-0
更新日期:1998-07-01 00:00:00
abstract::Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitam...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(82)90063-0
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Chronic administration of exogenous glucocorticoids is often required in experimental research. We compared the efficacy and reliability of three different methods of continuous glucocorticoid administration in mice. MATERIALS AND METHODS:Male CD1 Swiss White mice aged 7-9 weeks received corticosterone (CS)...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.11.009
更新日期:2009-02-01 00:00:00
abstract::Steroidal nucleoside analogs were synthesized starting from testosterone. By reduction of the oxime of 17 beta-hydroxy-androst-4-en-3-one (testosterone), a mixture of the two amino epimers of C-3 were obtained. The 3 alpha-amino-androst-4-en-17 beta-ol was crystallized in 73% yield and coupled with 5-amino-4,6-dichlor...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00157-x
更新日期:2002-03-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose. Adhesion on U937 cells, expression of adhesion molecules, pro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.11.010
更新日期:2012-02-01 00:00:00
abstract::The left adrenal of two female dogs were perfused with either 3 muCi [4-14C]cpd. S (2) and 45 muCi [1, 2-3H] 21-deoxycortisone (Dog I), or with 1 muCi [4-14C] 17-hydroxyprogesterone and 65 muCi [1,2-3H] 21-deoxycortisone (Dog II). In Dog I, 40% of the perfused 21-deoxycortisone was converted to cortisone and 23% of cp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90078-2
更新日期:1977-08-01 00:00:00
abstract::The palladium-catalyzed coupling of various 17-iodo-delta 16 steroids (17-iodo-androst-16-ene, 17-iodo-4-methyl-4-aza-androst-16-en-3-one, and 17-iodo-4-aza-androst-16-en-3-one) with dialkyl phosphites (dimethyl phosphite, diethyl phosphite, and diisopropyl phosphite) was examined in detail. The only successful condit...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00121-6
更新日期:1995-12-01 00:00:00
abstract::The crystal structure of a Li(+) salt of a glucosyl derivative of lithocholic acid (lithium 3α-(α-d-glucopyranosyl)-5β-cholan-24-oate) has been solved. The crystal belongs to the orthorhombic system, P212121 spatial group, and includes acetone and water in the structure with a 1:1:2 stoichiometry. Monolayers, having a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.07.001
更新日期:2016-09-01 00:00:00
abstract::The properties of 5-ene-3 beta hydroxysteroid oxidoreductase (3 beta-HSD) from human placental homogenates were studied in vitro. The apparent Michaelis constants for 3 beta-HSD with the substrates pregnenolone (delta 5P) and dehydroepiandrosterone (DHA) were 170 nM and nM respectively. The optimal pH for both these s...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(79)80002-1
更新日期:1979-01-01 00:00:00
abstract::The metabolism of tamoxifen is being redefined in the light of several important pharmacological observations. Recent studies have identified 4-hydroxy N-desmethyltamoxifen (endoxifen) as an important metabolite of tamoxifen necessary for antitumor actions. The metabolite is formed through the enzymatic product of CYP...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.07.009
更新日期:2007-11-01 00:00:00
abstract::Steroid delta 4-5 alpha- and delta 4-5 beta-reductase activity was determined in 16 human mammary tumors and 8 DMBA-induced rat mammary tumors using a spectrophotometric assay. Steroid delta 4-5 alpha-reductase was present in all tumors investigated while delta 4-5 beta-reductase was detected in only 6 estrogen recept...
journal_title:Steroids
pub_type: 历史文章,杂志文章
doi:10.1016/s0039-128x(79)80010-0
更新日期:1979-01-01 00:00:00
abstract::To gain further insight into the mechanism for inactivation of aromatase by androst-5-ene-7,17-dione (1) and its 19-nor analog 4, 10 beta-oxygenated steroids 5 and 6, delta 1(10)-steroid 7, and 19-oxo-5 beta,6 beta-epoxy compound 8 were synthesized and tested for their ability to inhibit aromatase in human placental m...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00002-0
更新日期:1997-07-01 00:00:00
abstract::Evaluation of sex steroids in cervical mucus was performed at different phases of spontaneous or clomiphene-citrate-induced ovulatory cycles. To this end, 11 women with normal ovulatory cycles and 9 subjects with polycystic ovary syndrome of comparable age and body mass index were investigated. Serum and cervical mucu...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00074-4
更新日期:2000-01-01 00:00:00
abstract::We developed a sensitive, reliable, and accurate LC/ESI-MS/MS method for measurement of 3β-sulfooxy-7β-N-acetylglucosaminyl-5-cholen-24-oic acid and its glycine and taurine amides in urine. This atypical C24 bile acid has been reported previously to be present in the urine of patients with Niemann-Pick Type C (NPC) di...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.05.017
更新日期:2013-10-01 00:00:00
abstract::The mass spectral elimination of water in epimeric 1,3-diols of vitamin D3 (colecalciferol) series has been investigated. It was found that the mass spectra of these steroisomers differ sharply in the relative intensities of the ions M-H2O (m/e 382) and a-H2O (m/e +/- 34), where ion a (formed via formal cleavage of th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(79)90039-4
更新日期:1979-05-01 00:00:00