Abstract:
:Preimplantation rabbit embryos were incubated with pregnenolone and dehydroisoandrosterone under conditions which gave formazan precipitation by the histochemical technique. The metabolic fate of the labeled steroids was assessed simultaneously. There was no concomitant transformation of pregnenolone to progesterone and dehydroisoandrosterone was not transformed to androstenedione. It is concluded that the formazan precipitation is coupled with an "activity" other than delta 5-3 beta-hydroxysteroid oxidoreductase.
journal_name
Steroidsjournal_title
Steroidsauthors
Bleau Gdoi
10.1016/s0039-128x(81)80012-8subject
Has Abstractpub_date
1981-02-01 00:00:00pages
121-32issue
2eissn
0039-128Xissn
1878-5867pii
S0039-128X(81)80012-8journal_volume
37pub_type
杂志文章相关文献
STEROIDS文献大全abstract::3 alpha-Hydroxysteroid dehydrogenase (3 alpha HSD) is one of the main enzymes involved in the metabolism of the active androgen, dihydrotestosterone (DHT). 3 alpha HSD catalyzes the reversible reduction of DHT to 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha DIOL). The equilibrium of 3 alpha HSD reductive and oxid...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90110-4
更新日期:1994-04-01 00:00:00
abstract::Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. Steroidal thiosemicarbazone derivatives were obtained...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.05.001
更新日期:2017-08-01 00:00:00
abstract::A convenient procedure for the synthesis of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol via a modified homologation sequence of the intermediate 3 alpha,7 alpha,12 alpha-triformyloxy-24-oxo-25-diazo-25-homo-5 beta-cholane involving a homogeneous medium is described. This involves treating the intermediate alp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90144-0
更新日期:1980-04-01 00:00:00
abstract::The synthesis of a radioiodinated diethylstilbestrol (DES) derivative is described. This derivative was prepared by coupling the previously synthesized active ester of 6-(4-O-diethylstilbestryl)hexanoic acid with mono-[125I]iodotyramine in dry tetrahydrofuran (20 to 22 C, 16 hours). The mono-[125I]iodotyramine was pre...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(92)90092-n
更新日期:1992-01-01 00:00:00
abstract::17beta-estradiol exerts an antiapoptotic action in skeletal muscle cells through extranuclear ERalpha and beta. This protective action, mainly involves a non-genomic mechanism of ERK1/2 and PI3K/Akt activation and BAD phosphorylation. ERbeta plays a major role in the inhibition of apoptosis by 17beta-estradiol at the ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.12.027
更新日期:2008-10-01 00:00:00
abstract::Effective syntheses of endo- and exocyclic alpha,beta-unsaturated ketones as CC dipolarophiles were carried out in the 13alpha-estrone series. The 1,3-dipolar cycloadditions of 15,16alpha,beta-unsaturated ketones of 13alpha-estrone 3-methyl and 3-benzyl ether with nitrilimines stereoselectively furnished two regioisom...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.02.001
更新日期:2009-06-01 00:00:00
abstract::Plasma concentration measurements of 13C-labeled cortisol ([1,2,4,19-13C(4)]cortisol, cortisol-13C(4)) and its metabolite cortisone-13C(4) were made simultaneously with measurements of endogenous cortisol and cortisone by gas chromatography-mass spectrometry (GC-MS). After administering a small amount (3mg) of cortiso...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00037-5
更新日期:2002-08-01 00:00:00
abstract::Enzyme immunoassays (EIA) are commonly utilized for the evaluation of androgens in biological fluids; however, careful consideration must be given to cross-reactivity with other endogenous sex-steroid hormones. Our purpose was to determine the validity of a commonly-utilized commercially-available dihydrotestosterone ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.08.013
更新日期:2013-12-11 00:00:00
abstract::Inhibitors of estrogen 2-hydroxylase can be utilized in studying the kinetics of this cytochrome P450 enzyme complex and in elucidating the structural requirements of the active site. The conversion of estrogens to 2-hydroxyestrogens in rat liver microsomal preparations was examined using two radiotracer assays, the c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(83)90120-4
更新日期:1983-07-01 00:00:00
abstract::Carbon-13 nuclear magnetic resonance spectra for 31 3 beta-hydroxy and acetoxy androstane derivatives bearing vicinal oxygenated functions at ring D with and without oxygenated functions at C-6 are reported. Relative substituent effects are discussed. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90077-9
更新日期:1991-04-01 00:00:00
abstract::Antiandrogens are widely used agents for the treatment of androgen dependent diseases as inhibitors of androgen receptors (AR) action. Although the precise mechanism of antiandrogen action is not yet elucidated, recent studies indicate the involvement of the structure of the ligand in relation with the nuclear co-repr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.03.006
更新日期:2008-09-01 00:00:00
abstract::A variety of progestins are available for therapeutic use. It is convenient to classify them into those related in chemical structure to progesterone or testosterone. Progestins related to progesterone can be subdivided into pregnanes and 19-norpregnanes, whereas those related to testosterone can be subdivided into th...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2003.08.003
更新日期:2003-11-01 00:00:00
abstract::Morphologic changes at the interface of rat endometrial luminal epithelial cells and the stromal cells immediately adjacent were examined and correlated with hypertrophy of the epithelial cells during estradiol (E2) infusion (1 microgram E2/24 h). While the lamina densa in castrate endometrium was thread-like, it beca...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90061-y
更新日期:1991-03-01 00:00:00
abstract::Ventral prostate was used as a system to study the nature and properties of microsomal androgen receptor. The endoplasmic reticulum from rat ventral prostate contains high-affinity, low-capacity binding sites for androgen that are intrinsic to this intracellular compartment. Microsomal androgen receptors are not due t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90126-g
更新日期:1991-02-01 00:00:00
abstract::Inhibition of 5alpha-reduction of testosterone by an anti-androgen TSAA-291 (16beta-ethyl-17beta-hydroxy-4-estren-3-one) was studied in rat ventral prostates and the metabolic conversion of 3H-TSAA-291 was examined both in vitro and in vivo. In the in vitro experiment using nuclear 5alpha-reductase of the prostate, 5a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(81)90021-0
更新日期:1981-07-01 00:00:00
abstract::For the purpose of describing the pathway by which estrones are synthesized in the rhesus monkey (Macaca mulatta) corpus luteum (CL), CL were obtained during the midluteal phase of the menstrual cycle and fragments incubated with equimolar amounts of [7-3H]pregnenolone plus [4-14C]progesterone. Metabolites including 3...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90019-7
更新日期:1980-08-01 00:00:00
abstract::Extranuclear estrogen receptors may mediate rapid effects of estradiol that communicate with nuclear receptors and contribute to proliferation of human cancers bearing these signaling proteins. To assess these growth-promoting pathways, we undertook controlled homogenization and fractionation of NIH-H23 non-small cell...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.02.017
更新日期:2005-05-01 00:00:00
abstract::The nature of the water-soluble products formed by incubating labelled estradiol with uterine peroxidase in the presence of H2O2 and tyrosine was examined by two-dimensional thin-layer chromatography and high voltage electrophoresis. It was shown that the steroid and amino acid were associated in a 1:2 or 1:3 ratio an...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90072-1
更新日期:1977-04-01 00:00:00
abstract::Aldosterone induces fibrotic changes in cardiovascular tissues but its effects have usually been demonstrated in models of pre-existing renal injury and/or hypertension. This study tests the hypothesis that aldosterone can directly induce vascular fibrotic changes in the absence of prior renal injury or hypertension. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.12.007
更新日期:2013-03-01 00:00:00
abstract::In this study, effects of estradiol, progesterone and genistein on uterine aquaporin (AQP)-1, 2, 5 and 7 expression were investigated in sex-steroid deficient state which could help to elucidate the mechanisms underlying uterine fluid volume changes that were reported under these hormone and hormone-like compound infl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.08.007
更新日期:2016-11-01 00:00:00
abstract::The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12 beta-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17 beta-hydroxy-12 beta-methyl-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn-3-one (37) and...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(92)90020-a
更新日期:1992-11-01 00:00:00
abstract::This study was designed to describe the time-course changes of catabolic proteins following muscle atrophy induced by 10 days of dexamethasone (DEX). Rats underwent DEX treatment for 1, 3, 5, 7 and 10 days. Body weight (BW) and lean mass were obtained using a dual energy X-ray absorptiometry (DEXA) scan. Muscle ringer...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.12.016
更新日期:2016-03-01 00:00:00
abstract::15alpha-Hydroxydehydroisoandrosterone and 15alpha-hydroxypregnenolone were isolated from hydrolyzed extracts of human late pregnancy urine and identified by means of the isotope dilution technique. In two separate determinations the excretion rate of 15alpha-hydroxydehydroisoandrosterone was found to be 1.7 and 3.2 mi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(78)80002-6
更新日期:1978-05-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions in humans and rodents, but its effects on renal tissue have not yet been fully understood. The aim of this study is to assess the effect of DHEA treatment on diabetic rats, mainly in relation to renal function and...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.006
更新日期:2011-05-01 00:00:00
abstract::This article describes the oxidation of cholesta-5,7-dien-3beta-yl acetate (4) with the urea-hydrogen peroxide adduct (UHP) using methyltrioxorhenium (MTO) as catalyst, under various conditions. Specifically, the effects of using different solvents (CHCl(3) and ethers) and additives (EtOH and pyridine) on the course o...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00017-x
更新日期:2002-06-01 00:00:00
abstract::The receptor profiles and in vivo activity of tibolone, and its primary metabolites, Delta(4)-isomer, and 3alpha- and 3beta-hydroxytibolone, were studied and compared to those of structurally related compounds. The Delta(4)-isomer was the strongest binder and activator of the progesterone receptor (PR); tibolone was 1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00112-5
更新日期:2003-01-01 00:00:00
abstract::A variety of compounds, including the selective estrogen receptor (ER) modulators tamoxifen and raloxifene, phytoestrogens such as genistein, and xenoestrogens such as bisphenol, bind to the estrogen receptor and elicit biological responses. Structural studies have linked the altered activity of compounds such as 4-hy...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2004.03.014
更新日期:2004-06-01 00:00:00
abstract::The sterol mixture isolated from the marine alga Eutreptia viridis consists mainly of delta 5,7-dienes which account for 80% of the free sterols. Eighteen different sterols were detected, including a novel sterol with the rare delta 23-unsaturation, viz. 24-ethylcholesta-5,7,23Z-trien-3 beta-o1. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(82)90018-6
更新日期:1982-10-01 00:00:00
abstract::Gypensapogenin H (GH) is a novel dammarane-type triterpenes obtained from hydrolyzate of total saponins from Gynostemma pentaphyllum and its anti-tumor activity has been studied in previous work. In this study, we report the effects of this compound on human prostate cancer cells (DU145 and 22RV-1). It significantly i...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.10.014
更新日期:2015-12-01 00:00:00
abstract::A partial synthesis of the title compound, 4'-(dimethylamino)-17 beta-hydroxy-17 alpha-(1-propynyl)benzo[12,12a]-11 alpha,18-cyclo-12a,12b- dihomo-13 alpha-estr-4-en-3-one 1, is reported. The key step in this synthesis represents an intramolecular alkenylaryl radical cyclization. Treatment of 18-[bromo-5-(dimethylamin...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90026-4
更新日期:1994-03-01 00:00:00