Abstract:
:Carbon-13 nuclear magnetic resonance spectra for 31 3 beta-hydroxy and acetoxy androstane derivatives bearing vicinal oxygenated functions at ring D with and without oxygenated functions at C-6 are reported. Relative substituent effects are discussed.
journal_name
Steroidsjournal_title
Steroidsauthors
Doller D,Gros EGdoi
10.1016/0039-128x(91)90077-9subject
Has Abstractpub_date
1991-04-01 00:00:00pages
168-72issue
4eissn
0039-128Xissn
1878-5867pii
0039-128X(91)90077-9journal_volume
56pub_type
杂志文章相关文献
STEROIDS文献大全abstract::The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.04.011
更新日期:2008-10-01 00:00:00
abstract::Cholesterol side-chain cleavage (CSCC) and aromatase activities were measured in luteal mitochondria and tissue pieces, respectively, from rhesus monkeys on days 22, 49, 128 and 160 of gestation. CSCC activity did not vary significantly during gestation and thus probably does not respond to chorionic gonadotropin whic...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90042-3
更新日期:1977-02-01 00:00:00
abstract::Starting from the structure of ice (in which each water molecule is surrounded by other four water molecules forming a tetrahedron with a value of 4.51Å for the edge O-O distance), and the knowledge that this value also corresponds to the O7-O12 distance of the skeleton of cholic acid, it is hypothesized that two ster...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.07.003
更新日期:2012-10-01 00:00:00
abstract::Nuclear membrane bound testosterone 5 alpha-reductase solubilized in active form from human prostatic tissue by 0.5% n-octyl beta-D-glucopyranoside was purified by a four-step chromatographic procedure including DEAE-Trisacryl ion exchange, hydroxylapatite adsorption, testosterone-Sepharose affinity and Sepharose 4B g...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90103-1
更新日期:1994-12-01 00:00:00
abstract::Inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) regulate the activity of the hypothalamo-pituitary-adrenal (HPA) axis at several levels. Although hypothalamic CRH secretion may be the primary mechanism by which these cytokines activate the HPA axis, IL-1 expression is increased within t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.04.018
更新日期:2011-09-01 00:00:00
abstract::The concentrations of C-19 steroids were measured in guinea pig and rat adrenals before and after castration as well as after stimulation with adrenocorticotropin hormone (ACTH). Characterization of adrenal C-19 steroids was also carried out by isolation with high-performance liquid chromatography and gas chromatograp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(90)90060-o
更新日期:1990-08-01 00:00:00
abstract::Formestane (F, androst-4-en-4-ol-3,17-dione) is an irreversible aromatase inhibitor with the ability to suppress the estrogen production from anabolic steroids. Consequently, F is mentioned on the World Anti-Doping Agency (WADA) prohibited list and because studies have shown that F is produced endogenously in small am...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.07.011
更新日期:2013-11-01 00:00:00
abstract::The effects of progesterone, its agonists (progestin RU-5020, glucocorticoid RU-26988) and antagonist (antiprogesterone, anti-glucocorticoid RU-486) were tested on isolated fat cells in vitro. When added to the incubation medium, all four steroids decreased basal glucose oxidation. The inhibitory effect of the steroid...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(88)90125-0
更新日期:1988-11-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA) supplementation has been anecdotally considered as a tool to improve body composition and health status. We aimed to verify the impact of DHEA supplementation on traditional measurements of body composition and blood pressure (BP) due to their clinical applicability. A meta-analysis of ra...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2020.108710
更新日期:2020-11-01 00:00:00
abstract::The free sterol mixture of the sponge Psammaplysilla purpurea was shown to contain aplysterol as the major constituent. In addition to other sterols such as 5,7-cholestadien-3beta-ol, cholesterol, 5alpha-cholestan-3beta-ol, 24epsilon-methylcholesta-5,22-dien-3beta-ol, 24epsilon--methylcholesterol, 24epsilon-ethylchole...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(78)80046-4
更新日期:1978-06-01 00:00:00
abstract::It is known that follicle-stimulating hormone (FSH) and insulin stimulate estradiol secretion from cultured non-luteinizing granulosa cells. The interaction between these hormones is less well understood. Granulosa cells from small (2-4 mm) bovine follicles were cultured in serum-free medium to determine if cytochrome...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00218-x
更新日期:2001-06-01 00:00:00
abstract::The role played by progestogens in modulating Schwann cell pathophysiology is well established. Progestogens exert their effects in these cells through both classical genomic and non-genomic mechanisms, the latter mediated by the GABA-A receptor. However, there is evidence that other receptors may be involved. Membran...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.09.009
更新日期:2019-02-01 00:00:00
abstract::Glucocorticoids are well-recognized modulators of immunocytes and osteoblasts via specific receptor-mediated mechanisms. We have evaluated the in vitro effect of interleukin 2 (IL-2) on the expression of glucocorticoid receptors (GRs) in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors and osteo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00023-3
更新日期:1998-05-01 00:00:00
abstract::The preparation of ring-A fused pyrimidines at the steroidal 2,3-position is herein described. The novel steroidal pyrimidines were prepared from the solid phase three-component reaction of 2-hydroxymethylene-3-keto steroids, arylaldehydes and ammonium acetate under microwave irradiation. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.03.006
更新日期:2009-09-01 00:00:00
abstract::There is considerable evidence that although estradiol may trigger the preovulatory surge of gonadotropins, progesterone is required for its full magnitude and duration and that glucocorticoids bring about selective follicle-stimulating hormone release. The luteinizing hormone-releasing hormone (LHRH) neuron does not ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(98)00031-2
更新日期:1998-05-01 00:00:00
abstract::Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitam...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(82)90063-0
更新日期:1982-04-01 00:00:00
abstract::Carbon-11-labeled casimiroin analogues were first designed and synthesized as new potential PET agents for imaging of quinone reductase (QR) 2 and aromatase expression in breast cancer. [(11)C]casimiroin (6-[(11)C]methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one, [(11)C]11) and its carbon-11-labeled analogues 5,...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.06.004
更新日期:2010-12-01 00:00:00
abstract::Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cell...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.11.017
更新日期:2009-07-01 00:00:00
abstract::By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first penta...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.04.003
更新日期:2011-09-01 00:00:00
abstract::The apolar ecdysteroid present in the developing embryo of the blue crab, Callinectes sapidus Rathbun, is tentatively identified as ponasterone A (2 beta, 14 alpha, 20,22-pentahydroxy-5, beta-cholest-7-en-6-one) on the basis of chromatographic, immunological, and mass spectral evidence. The apolar ecdysteroid present ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(79)90092-8
更新日期:1979-12-01 00:00:00
abstract::The adverse effects of hypercortisolism on the human brain have been highlighted in previous studies of Cushing's disease (CD). However, the reversibility of brain damage after the resolution of hypercortisolism remains unclear. Thus, we studied the potential volumetric reversibility in biochemically remitted CD patie...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108457
更新日期:2019-11-01 00:00:00
abstract::We report the synthesis of 10 novel steroids obtained from 3 beta, 15 beta-diacetoxy-17 alpha-hydroxy-5-pregnen-20-one (1c) as intermediates in the synthesis of 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-4-pregnen-3-one (6a) and its tritiated tracer 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-1,2,6,...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00204-8
更新日期:1997-02-01 00:00:00
abstract::To investigate the effects of conjugated bile acid on bacterial growth and cholylglycine hydrolase activity, Clostridium perfringens from human feces was exposed to varying concentrations of taurine- or glycine-conjugated chenodeoxycholic acid. Extracellular enzyme activity was determined by deconjugation of radiolabe...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90062-0
更新日期:1994-08-01 00:00:00
abstract::We have investigated the metabolism of deoxycorticosterone in A6 cells, a continuous cell line derived from the kidney of Xenopus laevis. A6 cells at confluence were incubated with serum-free culture media containing 2.5 microM [3H] deoxycorticosterone. When radioactive compounds in incubation media were separated by ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00038-r
更新日期:1995-07-01 00:00:00
abstract::Previous studies have demonstrated a persistent rise in serum cortisol concentrations after cardiac surgery. To further investigate this finding and to evaluate the effect of hemodilution that occurs with the onset of cardiopulmonary bypass (CPB), concentrations of cortisol-binding globulin (CBG), total and unbound co...
journal_title:Steroids
pub_type: 临床试验,杂志文章
doi:10.1016/s0039-128x(00)00133-1
更新日期:2000-09-01 00:00:00
abstract::(25S)-3-Oxocholesta-1,4-dien-26-oic acid (1) and a new (25S)-18-acetoxy-3-oxocholesta-1,4-dien-26-oic acid (2) were isolated from a soft coral Minabea sp. (cf. aldersladei) collected in North Sulawesi, Indonesia, together with two known cholic-acid-type compounds, 3-oxochol-1,4-dien-24-oic acid (3) and 3-oxochol-4-en-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.04.002
更新日期:2009-09-01 00:00:00
abstract::MDL 18,962 was shown to be a highly specific, potent (Ki = 3-4 nM), enzyme-activated inhibitor of aromatase with minimal intrinsic endocrine properties. The affinity of MDL 18,962 was higher for human and baboon placental aromatase than for rhesus placental or rodent ovarian aromatase. These species differences necess...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(83)90065-x
更新日期:1987-07-01 00:00:00
abstract::The catalytic cycloalumination of 2'-methylidene-2',3'-ethano-(5α)-cholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give spiro[2',3'-ethano-(5α)-cholestane-2',3″-aluminacyclopentane] in a ~75% yield and with high stereoselectivity (>98%). The obtained cyclic organoaluminum compound was t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.09.007
更新日期:2013-12-11 00:00:00
abstract::Desoxymethyltestosterone (DMT; 17β-hydroxy-17α-methyl-5α-androst-2-ene) is a designer steroid present in hormonal supplements distributed illegally as such or in combination with other steroids, for self-administration. It figures on the list of substances prohibited in sports and its detection in athlete's urine samp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.02.008
更新日期:2012-05-01 00:00:00
abstract::The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the ster...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2006.12.006
更新日期:2007-03-01 00:00:00