Abstract:
:By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first pentacyclic sterol glycoside with 6-6-6-5-6 fused rings. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis, including that of 2D NMR data, and the results of acidic hydrolysis. The cytotoxicity of the selected steroidal glycosides (1-4, 8, and 9) was evaluated in vitro against five human cancer cell lines. Compound 9 showed significant inhibitory activity against all five cell lines.
journal_name
Steroidsjournal_title
Steroidsauthors
Li L,Ni W,Li XR,Hua Y,Fang PL,Kong LM,Pan LL,Li Y,Chen CX,Liu HYdoi
10.1016/j.steroids.2011.04.003subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1037-42issue
10-11eissn
0039-128Xissn
1878-5867pii
S0039-128X(11)00136-Xjournal_volume
76pub_type
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