The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: A meta-analysis of randomized clinical trials.

abstract：:This report details the synthesis of 1) 3,4,4'-trihydroxy-alpha, alpha'-diethyl-trans-stilbene; 2) 3,4-bis-(p-hydroxyphenyl)-trans-3-hexenol; 3) 3,4-bis-(p-hydroxyphenyl)-2,4-cis,cis-hexadienol; 4) 3,4-bis-(3'-methoxy-4'-hydrophenyl)-trans-3-hexene; 5) 3,4-bis-(3',4'-dimethoxyphenyl)-trans-3-hexene. These compounds ar...

journal_title：Steroids

authors： Hill KA,Peterson DM,Damodaran KM,Rao PN

更新日期：1981-03-01 00:00:00

abstract：:Urinary steroid profile analysis requires enzymatic hydrolysis of glucuronide and sulfate conjugates and this is achieved simultaneously using Helix pomatia juice (HPJ), but steroids with 3beta-hydroxy-5-ene structure undergo transformation and yield of 5alpha-reduced corticosteroid glucuronides is poor. We describe t...

journal_title：Steroids

authors： Christakoudi S,Cowan DA,Taylor NF

更新日期：2008-03-01 00:00:00

abstract：:An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The abso...

journal_title：Steroids

authors： Jia P,Wu X,Yu Y,Zhang G

更新日期：2009-02-01 00:00:00

abstract：:We investigated the modulatory effect of estriol (E(3)), an estrogen predominantly produced during human pregnancy, on the antigen-induced production of specific antibodies in female BALB/c mice, and its effect was compared with 17beta-estradiol (E(2)). Estriol (E(3)) had a very different effect than E(2) on the antig...

journal_title：Steroids

authors： Ding J,Zhu BT

更新日期：2008-03-01 00:00:00

abstract：:This study examines the distribution of 5 alpha-reductase and 3 alpha(beta)-hydroxysteroid dehydrogenase activities throughout the intact hyperplastic prostate gland and relate these measurements to the fibromuscular/epithelial composition and to the gross glandular morphology. The relative capacities of the stroma an...

journal_title：Steroids

authors： Habib FK,Beynon L,Chisholm GD,Busuttil A

更新日期：1983-01-01 00:00:00

abstract：:In an attempt to synthesize compounds with selective estrogen-receptor binding, fluoro- and amino-clomiphene were totally synthesized from benzyl chloride, and their estrogenic/antiestrogenic activity as well as that of some of their chemical intermediates was evaluated. The triazene prepared from the amino-clomiphene...

journal_title：Steroids

authors： Gazit A,Livshitz T,Shani J

更新日期：1986-07-01 00:00:00

abstract：:Key to the production of biologically active steroids is the enzyme 3 beta-hydroxysteroid dehydrogenase-isomerase. Some controversy has arisen concerning the subcellular distribution of this enzyme within steroidogenic cells. The distribution of 3 beta-hydroxysteroid dehydrogenase-isomerase was assessed in subcellular...

journal_title：Steroids

authors： Perry JE,Ishii-Ohba H,Stalvey JR

更新日期：1991-06-01 00:00:00

abstract：:Catalytic cycloalumination of (3β,5α)-3-vinylcholestane and (3α,5α)-3-allylcholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give previously unknown aluminacyclopentanes in ∼90% yield; these products were converted in situ to carbo- and heterocyclic (5α)-cholestane derivatives. ...

journal_title：Steroids

authors： D'yakonov VA,Tuktarova RA,Islamov II,Khalilov LM,Dzhemilev UM

更新日期：2016-04-01 00:00:00

abstract：:The mass spectral elimination of water in epimeric 1,3-diols of vitamin D3 (colecalciferol) series has been investigated. It was found that the mass spectra of these steroisomers differ sharply in the relative intensities of the ions M-H2O (m/e 382) and a-H2O (m/e +/- 34), where ion a (formed via formal cleavage of th...

journal_title：Steroids

authors： Zaretskii ZV

更新日期：1979-05-01 00:00:00

abstract：:In demyelinating or non-demyelinating neurodegenerative diseases, increased levels of 7-ketocholesterol (7KC), 7β-hydroxycholesterol (7β-OHC) and 24(S)-hydroxycholesterol (24S-OHC) can be observed in brain lesions. In 158N murine oligodendrocytes, 7KC triggers a complex mode of cell death defined as oxiapoptophagy, in...

journal_title：Steroids

authors： Nury T,Zarrouk A,Mackrill JJ,Samadi M,Durand P,Riedinger JM,Doria M,Vejux A,Limagne E,Delmas D,Prost M,Moreau T,Hammami M,Delage-Mourroux R,O'Brien NM,Lizard G

更新日期：2015-07-01 00:00:00

abstract：:Spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, were synthesized from commercially available stigmasterol by a four steps reactions. In addition, the effects of these phytosterols on cell growth and mitochondrial activity were evaluated on 158N murine oligodendrocytes, C6...

journal_title：Steroids

authors： Badreddine A,Karym el M,Zarrouk A,Nury T,El Kharrassi Y,Nasser B,Cherkaoui Malki M,Lizard G,Samadi M

更新日期：2015-07-01 00:00:00

abstract：:Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetyl...

journal_title：Steroids

authors： Grainger WS,Parish EJ

更新日期：2015-09-01 00:00:00

abstract：:Estrogen is an important atheroprotective molecule that causes the rapid dilation of blood vessels by stimulating endothelial nitric oxide synthase (eNOS). There is also evidence that estrogen modulates airway epithelial NO production, thereby potentially affecting bronchial hyperresponsiveness. Studies in cultured en...

journal_title：Steroids

authors： Shaul PW

更新日期：1999-01-01 00:00:00

abstract：:A new technique that permits measurement of Androgen-Binding Protein (ABP) is validated by reproducibility, linearity and correlation studies. Using this apparatus allowing Scatchard plot analysis, it is also possible to measure association and dissociation rate constants. In addition, it is a very useful tool for a r...

journal_title：Steroids

authors： Barbey P,Fradin S,Carreau S,Drosdowsky MA

更新日期：1988-10-01 00:00:00

abstract：:Sleep apnea is a disorder, which increasingly affects people worldwide. Whether the associated hypoxic events during sleep are central or obstructive in origin, the end result is excessive daytime sleepiness and an increased risk for several comorbidities, such as cardiovascular and neurodegenerative disorders. Sleep ...

journal_title：Steroids

authors： Snyder B,Cunningham RL

更新日期：2018-05-01 00:00:00

abstract：:The efficiencies for estrogen conjugate hydrolysis were compared between enzyme hydrolysis, acid solvolysis and a new method, ammonolysis. Samples included: 1) crystalline 1,3,5(10)-estratriene-3, 17 beta-diol disulfate (estradiol 3,17-disulfate), 2) squirrel monkey urine collected following an intravenous injection o...

journal_title：Steroids

authors： Bain JD,Kasman LH,Bercovitz AB,Lasley BL

更新日期：1984-06-01 00:00:00

abstract：:The luteinizing hormone (LH) surge initiates a cascade of proteolytic events that control ovulation. One of the genes induced by LH is the progesterone receptor (PR). Because mice with a mutant PR gene (PRKO) fail to ovulate and are infertile, we have used them as a model in which to determine PR target genes that mig...

journal_title：Steroids

authors： Robker RL,Russell DL,Yoshioka S,Sharma SC,Lydon JP,O'Malley BW,Espey LL,Richards JS

更新日期：2000-10-01 00:00:00

abstract：:The applications of sterically crowed trialkyksilyl ether derivatives to the analysis and characterization by thin-layer chromatography, gas chromatography and mass spectrometry, of metabolites of 2alpha, 3alpha-cyclopropano-5alpha-androstan-17beta-ol in the rabbit are described. These derivatives are complementary to...

journal_title：Steroids

authors： Quilliam MA,Templeton JF,Westmore JB

更新日期：1977-05-01 00:00:00

abstract：:Two isoforms of the androgen receptor (AR-A and AR-B), differing by a lack of the first 187 amino acids in the NH2-terminal transactivation domain of AR-A, are expressed in connective tissue and bone. Transient transfections of normal human osteoblastic cells (HOB) and of genital skin fibroblasts defective in AR (GSF-...

journal_title：Steroids

authors： Liegibel UM,Sommer U,Boercsoek I,Hilscher U,Bierhaus A,Schweikert HU,Nawroth P,Kasperk C

更新日期：2003-12-01 00:00:00

abstract：:Glycyrrhizic acid (GZA) and glycyrrhetinic acid (GRA) can be determined rapidly and precisely by high-performance liquid chromatography (HPLC) in biological fluids and tissues from experimental animals and humans. From plasma and tissues, GZA and GRA are extracted by organic solvents and the extracts can directly be u...

journal_title：Steroids

authors： Krähenbühl S,Hasler F,Krapf R

更新日期：1994-02-01 00:00:00

abstract：:7 beta-Methyl-chenodeoxycholic acid (7-MeCDC, 3 alpha, 7 alpha-dihydroxy-7 beta-methyl-5 beta-cholan-24-oic acid), 7 alpha-methyl-ursodeoxycholic acid (7-MeUDC, 3 alpha, 7 beta-dihydroxy-7 alpha-methyl-5 beta-cholan-24-oic acid), 7 xi-methyl-lithocholic acid (7-MeLC, 3 alpha-hydroxy-7 xi-methyl-5 beta-cholan-24-oic ac...

journal_title：Steroids

authors： Hylemon PB,Moody DP,Cohen BI,Une M,Mosbach EH

更新日期：1984-10-01 00:00:00

abstract：:Saturation analysis of the binding of [3H]dexamethasone [( 3H]DEX) to ammonium sulfate precipitates (ASPs) confirmed the presence of a limited-capacity, high-affinity binder in human adipose tissue cytosols. Various non-radioactive steroids competed with [3H]DEX for binding to the ASPs in the following sequence: dexam...

journal_title：Steroids

authors： Miller LK,Kral JG,Strain GW,Zumoff B

更新日期：1987-06-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone, respectively, is an important pre-receptor signaling pathway for the renal mineralocorticoid receptor (MR). This receptor has an equal affinity for the glucocorti...

journal_title：Steroids

authors： Stewart PM,Mason JI

更新日期：1995-01-01 00:00:00

abstract：:The importance of computer-aided drug design and development is clear nowadays. These approaches smooth the way of designing some efficient candidates based on drugs in use. At this place, we studied the mechanism of D4-abiraterone (D4A), the active metabolite of Abiraterone (Abi), binding to CYP17A1 compared with Abi...

journal_title：Steroids

authors： Mehralitabar H,Ghasemi AS,Gholizadeh J

更新日期：2021-01-17 00:00:00

abstract：:[7beta-3H]-(24R and 24S)-27-nor-24-methyl-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acids and [7beta-3H]-27-nor-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid (C27 and C26 bile acids having the same nuclear configuration as cheno-deoxycholic acid and its precursor, 3alpha,7alpha-dihydroxy-5beta-cholestan-26-...

journal_title：Steroids

authors： Kihira K,Mosbach EH

更新日期：1978-12-01 00:00:00

abstract：:Spermatozoa from bovine ejaculates and cauda epiditymidis were incubated with either tritiated 17 beta-hydroxy-5 alpha-androstane-3-one (DHT) or 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). Examination of the medium incubations demonstrated metabolic conversion of both DHT and 3 alpha-diol when these steri...

journal_title：Steroids

authors： Djöseland O,Høglo S,Nyberg K,Hastings CD,Attramadal A

更新日期：1978-03-01 00:00:00

abstract：:7-Oxo-dehydroepiandrosterone, which can be formed from dehydroepiandrosterone (DHEA) by several mammalian tissues, is more effective than its parent steroid as an inducer of thermogenic enzymes when administered to rats. Using the Morris water maze procedure, we tested DHEA and its 7-oxo-derivative for their ability t...

journal_title：Steroids

authors： Shi J,Schulze S,Lardy HA

更新日期：2000-03-01 00:00:00

abstract：:We have previously shown that the photoactive 4-azasteroid, [1,2 3H]N-4(benzylbenzoyl)-3-oxo-4-aza-4-methyl-5alpha-androst an-17beta-carboxamide is an effective probe of rat steroid 5alpha-reductase (isozyme-1) (5alphaR-1). In the current investigation, PEG-fractionated (6.5%) detergent-solubilized preparations contai...

journal_title：Steroids

authors： Bhattacharyya AK,Wang M,Rajagopalan K,Taylor MF,Hiipakka R,Liao S,Collins DC

更新日期：1999-03-01 00:00:00

abstract：:The ability of human adult adrenal to utilize progesterone (P4) for cortisol (F) synthesis in vitro has been compared with that of fetal adrenal tissue. Explant cultures were studied for 6 days using Ham's F10 medium supplemented with 10% fetal bovine serum (FBS), with or without added P4 as substrate. Short-term (4h)...

journal_title：Steroids

authors： Branchaud CL,Lipowski L,Dhanani B,Goodyer CG,Lefebvre Y

更新日期：1986-04-01 00:00:00

abstract：:A direct competitive heterologous enzyme-linked immunosorbent assay (ELISA) was developed and validated to determine follicular fluid estradiol levels of different antral follicular sizes (small, medium, and large) obtained from the ovaries of heifers in the follicular phase of the estrous cycle. Polyclonal antiestrad...

journal_title：Steroids

authors： Silván G,Illera JC,Illera M

更新日期：1993-07-01 00:00:00