Abstract：
:The ability of human adult adrenal to utilize progesterone (P4) for cortisol (F) synthesis in vitro has been compared with that of fetal adrenal tissue. Explant cultures were studied for 6 days using Ham's F10 medium supplemented with 10% fetal bovine serum (FBS), with or without added P4 as substrate. Short-term (4h) incubations of fresh tissue minces were carried out in Ham's F10, with or without P4, in the absence of FBS. In contrast with the fetal gland, F production by cultured adult tissue was unaffected by addition of P4. During short-term incubations, P4 increased F production 150-fold in the fetal tissue as compared to 2- to 4-fold in the adult. ACTH had no acute effect on the P4 to F conversion in either tissue. These results demonstrate that the fetal adrenal exhibits a greater ability to utilize P4 for F production than the adult adrenal.
journal_name
Steroidsjournal_title
Steroidsauthors
Branchaud CL,Lipowski L,Dhanani B,Goodyer CG,Lefebvre Ydoi
10.1016/0039-128x(86)90097-8subject
Has Abstractpub_date
1986-04-01 00:00:00pages
269-85issue
4-5eissn
0039-128Xissn
1878-5867pii
0039-128X(86)90097-8journal_volume
47pub_type
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